Heliyon. 2024 Mar 30. 10(6): e27533
Hasin Hasnat,
Suriya Akter Shompa,
Md Mirazul Islam,
Safaet Alam,
Fahmida Tasnim Richi,
Nazim Uddin Emon,
Sania Ashrafi,
Nazim Uddin Ahmed,
Md Nafees Rahman Chowdhury,
Nour Fatema,
Md Sakhawat Hossain,
Avoy Ghosh,
Firoj Ahmed.
Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these natural substances are renowned, and initiatives are being taken to extract the flavonoids. Apigenin, galangin, hesperetin, kaempferol, myricetin, naringenin, and quercetin are the seven most common compounds belonging to this class. A thorough analysis of bibliographic records from reliable sources including Google Scholar, Web of Science, PubMed, ScienceDirect, MEDLINE, and others was done to learn more about the biological activities of these flavonoids. These flavonoids appear to have promising anti-diabetic, anti-inflammatory, antibacterial, antioxidant, antiviral, cytotoxic, and lipid-lowering activities, according to evidence from in vitro, in vivo, and clinical research. The review contains recent trends, therapeutical interventions, and futuristic aspects of flavonoids to treat several diseases like diabetes, inflammation, bacterial and viral infections, cancers, and cardiovascular diseases. However, this manuscript should be handy in future drug discovery. Despite these encouraging findings, a notable gap exists in clinical research, hindering a comprehensive understanding of the effects of flavonoids at both high and low concentrations on human health. Future investigations should prioritize exploring bioavailability, given the potential for high inter-individual variation. As a starting point for further study on these flavonoids, this review paper may promote identifying and creating innovative therapeutic uses.
Keywords: Antioxidants; Apigenin; Flavone; Flavonoids; Flavonol; Flavonone; Galangin; Hesperetin; Kaempferol; Myricetin; Naringenin; Quercetin