bims-actimu 2024-05-19 papers

Issue of 2024–05–19
two papers selected by
Elodie Busch, University of Strasbourg

Oxf Open Immunol. 2024 ;5(1): iqae002

Coronin 1-dependent cell density sensing and regulation of the peripheral T cell population size.

Tohnyui Ndinyanka Fabrice, Mayumi Mori, Jean Pieters.

The establishment and maintenance of peripheral T cells is important to ensure appropriate immunity. In mammals, T cells are produced in the thymus before seeding the periphery early in life, and thereafter progressive thymus involution impairs new T cell production. Yet, peripheral T cells are maintained lifelong at approximately similar cell numbers. The question thus arises: what are the mechanisms that enable the maintenance of the appropriate number of circulating T cells, ensuring that T cell numbers are neither too low nor too high? Here, we highlight recent research suggesting a key role for coronin 1, a member of the evolutionarily conserved family of coronin proteins, in both allowing T cells to reach as well as maintain their appropriate cell population size. This cell population size controlling pathway was found to be conserved in amoeba, mice and human. We propose that coronin 1 is an integral part of a cell-intrinsic pathway that couples cell density information with prosurvival signalling thereby regulating the appropriate number of peripheral T cells.

Keywords: T cell homeostasis; T cells; cAMP-Ca2+ signalling; cell population size regulation; coronin; immunodeficiency

DOI: https://doi.org/10.1093/oxfimm/iqae002

Med Oncol. 2024 May 14. 41(6): 151

WDR1 promotes prostate cancer progression through Wnt/β-catenin signaling.

Jinfeng Cheng, Dan Huo, Zhonghua Zhang, Jianqing Zhang, Bizhen Dong, Zhen Liu, Zhi Zhou, Yanjun Lu.

Prostate cancer (PCa) is the second most common cancer and the fifth leading cause of cancer-related death among men. A comprehensive understanding of PCa progression is crucial for the development of innovative therapeutic strategies for its treatment. While WDR1 (WD-repeat domain 1) serves as a significant cofactor of actin-depolymerizing factor/cofilin, its role in PCa progression remains unknown. In this study, we demonstrated that knockdown of WDR1 in various PCa cells substantially inhibited cell proliferation, migration, and invasion in vitro, as confirmed at both the cellular and molecular levels. Moreover, the overexpression of WDR1 promoted PCa cell proliferation and metastasis in vitro. Mechanistically, we showed that the application of lithium chloride, an activator of the Wnt/β-Catenin signaling pathway, restored the suppressive effects of WDR1 deficiency on cell proliferation and migration in PCa cells. Our findings suggest that the WDR1-β-Catenin axis functions as an activator of the malignant phenotype and represents a promising therapeutic target for PCa treatment.

Keywords: Metastasis; Proliferation; Prostate cancer; WDR1; Wnt/β-Catenin signaling

DOI: https://doi.org/10.1007/s12032-024-02388-4