bims-actimu Biomed News
on Actinopathies in inborn errors of immunity
Issue of 2023‒11‒12
one paper selected by
Elodie Busch, University of Strasbourg

  1. Cells. 2023 Oct 29. pii: 2541. [Epub ahead of print]12(21):
      Immune surveillance and adaptive immune responses, involving continuously circulating and tissue-resident T-lymphocytes, provide host defense against infectious agents and possible malignant transformation while avoiding autoimmune tissue damage. Activation, migration, and deployment of T-cells to affected tissue sites are crucial for mounting an adaptive immune response. An effective adaptive immune defense depends on the ability of T-cells to dynamically reprogram their metabolic requirements in response to environmental cues. Inability of the T-cells to adapt to specific metabolic demands may skew cells to become either hyporesponsive (creating immunocompromised conditions) or hyperactive (causing autoimmune tissue destruction). Here, we review maladaptive T-cell metabolic fitness that can cause autoimmune diseases and discuss how T-cell metabolic programs can potentially be modulated to achieve therapeutic benefits.
    Keywords:  LFA-1; T-cell function; T-cell motility; autoimmunity; glycolysis; metabolites; psoriasis; rheumatoid arthritis