bims-resufa Biomed news
on Respiratory Supercomplex Factors
Issue of 2018‒03‒11
one paper selected by
Josh Garlich
Medical College of Wisconsin

  1. Trends Endocrinol Metab. 2018 Feb 28. pii: S1043-2760(18)30022-5. [Epub ahead of print]
    Bargiela D, Burr SP, Chinnery PF.
      Alterations in mitochondrial metabolism influence cell differentiation and growth. This process is regulated by the activity of 2-oxoglutarate (2OG)-dependent dioxygenases (2OGDDs) - a diverse superfamily of oxygen-consuming enzymes - through modulation of the epigenetic landscape and transcriptional responses. Recent reports have described the role of mitochondrial metabolites in directing 2OGDD-driven cell-fate switches in stem cells (SCs), immune cells, and cancer cells. An understanding of the metabolic mechanisms underlying 2OGDD autoregulation is required for therapeutic targeting of this system. We propose a model dependent on oxygen and metabolite availability and discuss how this integrates 2OGDD metabolic signalling, the hypoxic transcriptional response, and fate-determining epigenetic changes.
    Keywords:  2-oxoglutarate-dependent dioxygenases; HIF; hypoxia; metabolism; mitochondria