bims-nocaut Biomed News
on Non-canonical autophagy
Issue of 2023‒08‒13
three papers selected by
Quentin Frenger, University of Strasbourg
  1. Glial cells LAP axon fragments.
  2. Activated STING1 rides the Rafeesome.
  3. Chloroplast microautophagy: A green role for NBR1.
  1. Autophagy. 2023 Aug 10.
    Glial cells LAP axon fragments.
    Áron Szabó, Gábor Juhász.
      In the nervous system, dead cell-derived material arising from injuries and neurodegeneration is normally removed by the phagocytic activity of macrophages or glia. Failure in this process can lead to excessive inflammation and secondary neurodegeneration. During phagocytosis, engulfed material is captured into phagosomes. Maturation and subsequent fusion of these vesicles with lysosomes may utilize components of the macroautophagy pathway that has been referred to as LC3-associated phagocytosis or LAP for short.
    Keywords:  Drosophila; Glia; LC3-associated phagocytosis; autophagy; injury; neurodegeneration; neuron; phagocytosis
    DOI:  https://doi.org/10.1080/15548627.2023.2246355
  2. Autophagy. 2023 Aug 06. 1-4
    Activated STING1 rides the Rafeesome.
    Yaping Han, Jianfei Zheng, Liang Ge.
      Over the past decade, accumulated studies have reported the presence of non-canonical macroautophagy/autophagy characterized by the shared usage of the autophagy machinery and distinct components that function in multiple scenarios but do not involve lysosomal degradation. One type of non-canonical autophagy is secretory autophagy, which facilitates the secretion of various cargoes. In a recent work from Gao et al. the ER-membrane protein STING1 has been identified as a novel substrate of secretory autophagy. The secretion of activated STING1 is mediated by its packing into the rafeesome, a newly identified organelle formed upon the fusion of RAB22A-mediated non-canonical autophagosome with an early endosome. Moreover, extracellular vesicles containing activated STING1 induce antitumor immunity in recipient cells, a process potentially promoted by RAB22A.
    Keywords:  Autophagosome; ERGIC; RAB22; Rafeesome; STING; Unconventional secretion
    DOI:  https://doi.org/10.1080/15548627.2023.2240154
  3. Autophagy. 2023 Aug 10.
    Chloroplast microautophagy: A green role for NBR1.
    Han Nim Lee, Sarika K Marathe, Marisa S Otegui.
      
    Keywords:  Autophagy receptor; NBR1; chlorophagy; chloroplast turnover; microautophagy; non-canonical autophagy; selective autophagy
    DOI:  https://doi.org/10.1080/15548627.2023.2246857
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