bims-madeba Biomed news
on Mal de débarquement syndrome
Issue of 2018‒10‒14
one paper selected by
Jun Maruta
Mount Sinai Health System


  1. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Oct 05. pii: S0278-5846(18)30422-6. [Epub ahead of print]89 310-321
    Hilber P, Cendelin J, Le Gall A, Machado ML, Tuma J, Besnard S.
      The discipline of affective neuroscience is concerned with the neural bases of emotion and mood. The past decades have witnessed an explosion of research in affective neuroscience, increasing our knowledge of the brain areas involved in fear and anxiety. Besides the brain areas that are classically associated with emotional reactivity, accumulating evidence indicates that both the vestibular and cerebellar systems are involved not only in motor coordination but also influence both cognition and emotional regulation in humans and animal models. The cerebellar and the vestibular systems show the reciprocal connection with a myriad of anxiety and fear brain areas. Perception anticipation and action are also major centers of interest in cognitive neurosciences. The cerebellum is crucial for the development of an internal model of action and the vestibular system is relevant for perception, gravity-related balance, navigation and motor decision-making. Furthermore, there are close relationships between these two systems. With regard to the cooperation between the vestibular and cerebellar systems for the elaboration and the coordination of emotional cognitive and visceral responses, we propose that altering the function of one of the systems could provoke internal model disturbances and, as a result, anxiety disorders followed potentially with depressive states.
    Keywords:  Anxiety disorders; Cerebellum; Depression; Internal model; Vestibular system
    DOI:  https://doi.org/10.1016/j.pnpbp.2018.10.004