bims-lorfki Biomed News
on Long non-coding RNA functions in the kidney
Issue of 2020‒10‒11
one paper selected by
Nikita Dewani
Max Delbrück Centre for Molecular Medicine

  1. Essays Biochem. 2020 Oct 09. pii: EBC20200033. [Epub ahead of print]
      Genetic variations, including single nucleotide polymorphisms (SNPs) and structural variations, are widely distributed in the genome, including the long noncoding RNA (lncRNA) regions. The changes at locus might produce numerous effects in a variety of aspects. Multiple bioinformatics resources and tools were also developed for systematically dealing with genetic variations associated with lncRNAs. Moreover, correlation of the genetic variations in lncRNAs with immune disease, cancers, and other disease as well as development process were all included for discussion. In this essay, we summarized how and in what aspects these changes would affect lncRNA functions.
    Keywords:  Genetic variations; function; long noncoding RNA