bims-fascar Biomed News
on Phase separation and cellular architecture
Issue of 2020‒04‒12
one paper selected by
Victoria Yan
Max Planck Institute of Molecular Cell Biology and Genetics

  1. Curr Opin Cell Biol. 2020 Apr 06. pii: S0955-0674(20)30044-2. [Epub ahead of print]63 194-203
    Shi M, Zhang P, Vora SM, Wu H.
      Higher-order supramolecular complexes-dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein-protein interactions or by dynamic liquid-liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.