bims-evares Biomed News
on Evaluation of research
Issue of 2022‒10‒23
fifty-six papers selected by
Thomas Krichel
Open Library Society


  1. Korean J Anesthesiol. 2022 Oct 17.
      Background: This study aimed to identify the directions of research published in the Korean Journal of Anesthesiology (KJA) and identify the main topics and journal network through a bibliometric analysis. The results can be reflected in strategies for the journal's promotion to a top-ranking journal in the anesthesiology category.Methods: KJA articles from 2017 to September 2022 were retrieved from the Web of Science Core Collection on September 11, 2022, and analyzed using Biblioshiny. Journal metrics, the document network, the conceptual structure, and social structures were elucidated.
    Results: Out of 525 articles, fewer than half (48.6%) were from Korean corresponding authors. The impact factor steeply increased from 2.316 in 2019 to 5.167 in 2021. The Hirsch index of KJA was 24. A co-occurrence network of Keywords Plus showed four clusters of central keywords: surgery, management, anesthesia, and mortality. The conceptual structure map of Keywords Plus showed a main cluster of anesthesia and analgesia, while another minor cluster included intubation and induction. The co-citation network demonstrated that KJA was in the same cluster of anesthesiology journals. The collaboration network of the authors' countries showed that Korean authors collaborated mainly with researchers in the United States and Canada.
    Conclusions: These results show KJA's developmental process of promotion to a top-tier journal in the anesthesiology category. Furthermore, the following strategies are suggested for journal promotion: recruitment of articles on emerging and highly citable topics; and more active collaboration of society members with researchers worldwide.
    Keywords:  Anesthesiology; Bibliometrics; Journal impact factor; Republic of Korea; Social structure
    DOI:  https://doi.org/10.4097/kja.22614
  2. J Oncol. 2022 ;2022 3382360
      Bladder cancer is a malignant tumor that occurs on the mucous membrane of the bladder. It is the most common malignant tumor of the urinary system and one of the top ten common tumors in the whole body. This bibliometric analysis was applied to identify the characteristics of global scientific output, the hotspots, and frontiers about treatment on bladder cancer with Chinese medicine monomer over the past 22 years. We retrieved publications published from 2000 to 2021 and their recorded information from Web of Science Core Collection (WoSCC). VOSviewer and CiteSpace were used to analyze bibliometric indicators and visualize the trend and hotspots of researches on bladder cancer with Chinese medicine monomer. Altogether, 658 original articles were reviewed, and the results showed that the annual number of publications (Np) shows an upward trend over the past 22 years as a whole. The US produced the most papers, and the number of citations (Nc) and H-index of the US ranked first. Johns Hopkins University and BJU International were the most prolific affiliation and journal, respectively. Recently, the keywords "NF-kappa B" appeared frequently. Besides, quercetin is the most thorough research in the treatment of bladder cancer with Chinese herbal compound, but whether quercetin is the most potent compound needs further study.
    DOI:  https://doi.org/10.1155/2022/3382360
  3. Front Neurol. 2022 ;13 953285
      Background: This study aimed to analyze the global research trends and map the knowledge network of intracranial aneurysm (IA) research in the last 10 years.Methods: Publications related to IA from 2012 to 2021 were retrieved from the Web of Science core collection. Microsoft Excel 2010 and VOSviewer were used to characterize the largest contributors, including authors, journals, institutions, and countries. CiteSpace and VOSviewer were adopted to analyze the trends and knowledge network of IA.
    Results: A total of 5,406 publications related to IA from 2012 to 2021 were identified, increasing from 344 in 2012 to 762 in 2021. Siddiqui, AH from the USA contributed the most publications. Papers published in the journal World Neurosurgery ranked first in quantity, while Stroke ranked first for total citations and citations per publication. The top three prolific institutions were Capital Medical University, Mayo Clinic, and the University Department of Neurology Utrecht from 2012 to 2021. Moreover, the USA held the greatest share in the field, and China was almost on par with the USA due to its rapid growth. Specifically, the most frequently covered topics over the recent decade were subarachnoid hemorrhage, endovascular treatment (EVT), clipping, vascular disorders, flow diverter, stent, delayed cerebral ischemia, inflammation, and hemodynamics.
    Conclusion: The contribution made by different countries, institutions, journals, and authors for IA research over the past decade was demonstrated in the paper. The main topics include the choice of EVT or surgical clipping, particularly the application of flow diverter and associated complications, while themes such as the etiopathogenetic features of IA (e.g., inflammation and hemodynamics) deserve more attention.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; flow diverter; intracranial aneurysm; mechanism
    DOI:  https://doi.org/10.3389/fneur.2022.953285
  4. Front Immunol. 2022 ;13 998217
      Background: The treatment of myasthenia gravis (MG) has advanced from steroids and traditional immunosuppressants to targeted immunotherapy. Targeted immunotherapy has been successfully employed in clinical practice in recent years. This study aimed to explore the emerging trend of targeted immunotherapy in MG and summarize the knowledge structure through bibliometric methods.Methods: The Web of Science Core Collection database (WoSCC) was chosen to retrieve the literature on targeted immunotherapy for MG. Two bibliometric analysis software, VOSviewer and CiteSpace, and bibliometric online platform were mainly used to evaluate the contributions from countries/regions, institutions, journals, and authors through the construction and visualization of bibliometric networks. By systematically reviewing a knowledge domain, future research developments were determined. The R version 4.1.2 and Microsoft Excel 365 were used for statistical analysis.
    Results: A total of 562 original articles and 262 reviews relevant to MG targeted immunotherapy were included. The number of publications on targeted immunotherapy for MG exhibited a two-phase advancement. The first stage showed a steady growth trend from 1998 to 2016, with an annual number of no more than 35 publications. The second stage revealed an explosive growth trend from 2017, reaching a peak number of publications in 2020. The United States ranked first in the number of publications, citations, and h-index. The author with the highest citation and h-index was Vincent A. And 28.03% of the articles were published in the top 10 journals. In addition to "myasthenia gravis", the keyword with the highest consideration was "rituximab", followed by "double-blind", which indicate research hotspots gradually from basic research to clinical research over time, especially in the field of targeted immunotherapy. The MG treatment has entered a personalized precision treatment phase. Exploration into new target molecules and conducting high-quality randomized controlled trials on existing biological agents are the further research direction.
    Conclusion: The current study summarized the global research trends concerning targeted immunotherapy for MG. Research interests gradually advanced from basic research to clinical research. MG treatment has entered a personalized precision treatment phase. Further investigations into new target molecules and high-quality randomized controlled trials on existing biological agents are required urgently to direct future immunotherapy research.
    Keywords:  Citespace; VOSviewer; bibliometric; myasthenia gravis; targeted immunotherapy
    DOI:  https://doi.org/10.3389/fimmu.2022.998217
  5. Aesthetic Plast Surg. 2022 Oct 19.
      BACKGROUND: It is very important to generate a comprehensive assessment of the fat grafting field due to the rapid growth of scientific literature. The current study aimed to use bibliometric analysis to evaluate fat grafting research qualitatively and quantitatively and determine the research hotspots and trends in this field.METHODS: Publications on fat grafting research were extracted from the Web of Science core collection database. VOSviewer 1.6.18 was applied to perform the bibliometric analysis of these articles.
    RESULTS: A total of 2558 studies published by 594 different journals authored by 9097 researchers were contained in this study. In the co-authorship analysis, the bulk of the retrieved studies was conducted by the USA, followed by China, Italy and Japan, while the most productive institution, journal and author were Chinese Academy of Medicine Sciences, Plastic and Reconstruction Surgery and Klinger M, respectively. In the co-cited analysis, the most top cited author, journal, organization and country were Coleman Sr, Plastic and Reconstruction Surgery, New York University and the USA, respectively. The map of keywords occurrence revealed the most active research aspects were focused on "surgery," "cell," "breast reconstruction" and "survival" and the time overlay mapping showed that the most active research hotspots were "breast reconstruction" and "retention".
    CONCLUSIONS: The research hotspots include the following four aspects: aesthetic surgeries, cell-assisted lipotransfer, breast reconstruction and grafted fat survival. Breast fat grafting and volume retention may be trends in the future. We are willing to provide more beneficial data to contribute valuable research for the fat grafting through this study.
    LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  Bibliometric analysis; Fat grafting; Hotspot; Trend
    DOI:  https://doi.org/10.1007/s00266-022-03137-6
  6. Front Oncol. 2022 ;12 987026
      Objective: To present the global research features and hotspots, and forecast the emerging trends by conducting a bibliometric analysis based on literature related to autophagy of pancreatic cancer from 2011 to 2022.Methods: The literature data regarding autophagy of pancreatic cancer were retrieved and downloaded from the Web of Science Core Collection (WOSCC) from Clarivate Analytics on June 10th, 2022. VOSviewer (version 1.6.18) was used to perform the bibliometric analysis.
    Results: A total of 616 studies written by 3993 authors, covered 45 countries and 871 organizations, published in 263 journals and co-cited 28152 references from 2719 journals. China (n=260, 42.2%) and the United States (n=211, 34.3%) were the most frequent publishers and collaborated closely. However, publications from China had a low average number of citations (25.35 times per paper). The output of University of Texas MD Anderson Cancer Center ranked the first with 26 papers (accounting for 4.2% of the total publications). Cancers (n=23, 3.7%; Impact Factor = 6.639) published most papers in this field and was very pleasure to accept related researches. Daolin Tang and Rui Kang published the most papers (n=18, respectively). The research hotspots mainly focused on the mechanisms of autophagy in tumor onset and progression, the role of autophagy in tumor apoptosis, and autophagy-related drugs in treating pancreatic cancer (especially combined therapy). The emerging topics were chemotherapy resistance mediated by autophagy, tumor microenvironment related to autophagy, autophagy-depended epithelial-mesenchymal transition (EMT), mitophagy, and the role of autophagy in tumor invasion.
    Conclusion: Attention has been increasing in autophagy of pancreatic cancer over the past 12 years. Our results undoubtedly provide scholars with new clues and ideas in this field.
    Keywords:  apoptosis; autophagy; bibliometric study; chemotherapy resistance; gemcitabine; pancreatic cancer
    DOI:  https://doi.org/10.3389/fonc.2022.987026
  7. Ann Thorac Surg. 2022 Oct 18. pii: S0003-4975(22)01326-1. [Epub ahead of print]
      BACKGROUND: Previous investigations have revealed significant gender disparities in the academic arenas of cardiothoracic surgery. However, the status of gender representation in cardiothoracic publications has not been well described. This study aimed to evaluate authorship trends by gender in two high-impact cardiothoracic surgical journals.METHODS: In this bibliometric analysis, PubMed was searched for articles published in the Annals of Thoracic Surgery and The Journal of Thoracic and Cardiovascular Surgery from 2010-2021. The web-based application Genderize.io was used to classify names of first and last authors as men versus women. The Cochran-Armitage trend test and multivariable logistic regression were used to evaluate authorship per year and the association of first and last author gender, respectively.
    RESULTS: Among 14,443 articles, 16.7% had women first authors and 8.1% had women last authors. The proportion of articles written by women authors increased, rising from 12.6% to 21.1% (p<0.0001) for first and 5.4% to 11.5% (p<0.0001) for last authors. Papers written with women as first author were associated with 2.0 higher odds of having a woman as last author (95% CI 1.7-2.3, p<0.0001). The mean number of last author publications was higher for men than for women (2.4 versus 1.7, p<0.0001).
    CONCLUSIONS: Over the past decade, despite a welcomed increase in women authorship in high-impact journals in cardiothoracic surgery, women represent a small proportion of published authors. Women first authors are more likely to publish with women last authors, demonstrating the impact of same-gender collaborations while emphasizing a need for cross-gender mentorship.
    Keywords:  Gender; authorship; mentorship; representation
    DOI:  https://doi.org/10.1016/j.athoracsur.2022.09.046
  8. J Control Release. 2022 Oct 18. pii: S0168-3659(22)00693-9. [Epub ahead of print]
      The limitations of traditional cancer treatments are driving the creation and development of new nanomedicines. At present, with the rapid increase of research on nanomedicine in the field of cancer, there is a lack of intuitive analysis of the development trend, main authors and research hotspots of nanomedicine in the field of cancer, as well as detailed elaboration of possible research hotspots. In this review, data collected from the Web of Science Core Collection database between January 1st, 2000, and December 31st, 2021, were subjected to a bibliometric analysis. The co-authorship, co-citation, and co-occurrence of countries, institutions, authors, literature, and keywords in this subject were examined using VOSviewer, Citespace, and a well-known online bibliometrics platform. We collected 19,654 published papers, China produced the most publications (36.654%, 7204), followed by the United States (29.594%, 5777), and India (7.780%, 1529). An interesting fact is that, despite China having more publications than the United States, the United States still dominates this field, having the highest H-index and the most citations. Acs Nano, Nano Letters, and Biomaterials are the top three academic publications that publish articles on nanomedicine for cancer out of a total of 7580 academic journals. The most significant increases were shown for the keywords "cancer nanomedicine", "tumor microenvironment", "nanoparticles", "prodrug", "targeted nanomedicine", "combination", and "cancer immunotherapy" indicating the promising area of research. Meanwhile, the development prospects and challenges of nanomedicine in cancer are also discussed and provided some solutions to the major obstacles.
    Keywords:  Bibliometrics; Cancer; Immunotherapy; Nanomedicine; Nanoparticle; Visualization
    DOI:  https://doi.org/10.1016/j.jconrel.2022.10.023
  9. Front Med (Lausanne). 2022 ;9 994534
      Background: Gastroesophageal reflux disease (GERD), a disorder resulting from the retrograde flow of gastric contents into the esophagus, affects an estimated 10-30% of the Western population, which is characterized by multifactorial pathogenesis. Over the past few decades, there have been many aspects of uncertainty regarding GERD leading to an ongoing interest in the field as reflected by a large number of publications, whose heterogeneity and variable quality may present a challenge for researchers to measure their scientific impact, identify scientific collaborations, and to grasp actively researched themes in the GERD field. Accordingly, we aim to evaluate the knowledge structure, evolution of research themes, and emerging topics of GERD research between 2012 and 2022 with the help of bibliometric approaches.Methods: The literature focusing on GERD from 2012 to 2022 was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection. The overall publication performance, the most prolific countries or regions, authors, journals and resources-, knowledge- and intellectual-networking, as well as the co-citation analysis of references and keywords, were analyzed through Microsoft Office Excel 2019, CiteSpace, and VOSviewer.
    Results: A total of 8,964 publications were included in the study. The USA published the most articles (3,204, 35.74%). Mayo Clin ranked first in the number of articles published (201, 2.24%). EDOARDO SAVARINO was the most productive author (86, 0.96%). The most productive journal in this field was SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (304, 3.39%). AMERICAN JOURNAL OF GASTROENTEROLOGY had the most co-citations (4,953, 3.30%). Keywords with the ongoing strong citation bursts were transoral incision less fundoplication, eosinophilic esophagitis, baseline impedance, and functional heartburn.
    Conclusion: For the first time, we obtained deep insights into GERD research through bibliometric analysis. Findings in this study will be helpful for scholars seeking to understand essential information in this field and identify research frontiers.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; gastroesophageal reflux disease; trends
    DOI:  https://doi.org/10.3389/fmed.2022.994534
  10. Medicine (Baltimore). 2022 Oct 14. 101(41): e31051
      Acute pancreatitis (AP) is a common digestive disease encountered in Emergency Departments that carries a heavy socioeconomic burden. This study was conducted to determine the global status of AP research. Articles related to AP published in 1999 to 2018 were retrieved from the Web of Science (WOS) database and the 20 highest-output countries or regions were determined based on the total number of publications. Correlation analysis of AP research output and the gross domestic product (GDP) of each country or region was conducted. The quantity and quality of research of these 20 highest-output countries were compared to the total output, outputs per capita, and average impact factor (IF). All annual data were analyzed using time-trend analysis. A keyword co-occurrence analysis was conducted to determine the highlights in AP research. In total, 17,698 publications were retrieved, and 16,461 papers (93.0%) of them were from the 20 highest-output countries. A significantly positive correlation was identified between AP research output and the GDP (R = 0.973, P < .001). The 5 highest-output countries were the USA (24.9%), China (12.3%), Germany (7.5%), Japan (6.7%), and the UK (6.1%). Finland ranked 1st in the number of publication per capita, the USA had the highest accumulated IF (25,432.758) and total citations (104,592), Switzerland had the highest average IF (6.723), and Netherland had the highest average citations (51.90). Genetic research and AP-related hyperglycemia were research highlights. Analysis of the global output of research of AP research showed signs of growth. Research output was positively correlated with GDP. For the most productive countries, research quality was stable. Although developing countries lagged behind in output per capita and quality, great progress has been made in the past 2 decades.
    DOI:  https://doi.org/10.1097/MD.0000000000031051
  11. Orthop Surg. 2022 Oct 20.
      OBJECTIVE: The treatment of chronic osteomyelitis (COM) is extremely challenging for physicians and patients. It is of great significance to explore the research status, development trend and future research hotspots in the field of COM to promote the development of this field. This study is aimed to explore the global research status of COM and predict its future research hotspots based on bibliometric and visualized analysis.METHODS: Web of Science core collection database was used to search the related literature of COM from 1994 to 2020. All data were imported into Microsoft Excel 2019 for collation. Additionally, the literature quality of countries, authors, journals, and institutions is evaluated. The VOS viewer software was used for conducting co-analysis, co-citation analysis, and keyword co-occurrence analysis of literature to analyze the global status and predict the future hotspots of the COM field.
    RESULTS: A total of 726 articles were retrieved in this study. The number of global publications shows a trend of wave growth, but the increase is not significant. It is expected that the number of COM articles will remain at more than 50 per year in the next decade. The COM literature published in the United States (Publications = 160, H index = 37, average citations per item = 28.63) is of the highest quality. Girschick HJ (Publications = 16, H index = 14, average citations per item = 52.25) is the most contributed scholar in the field of COM. UNIV IOWA (Publications = 15, H index = 11, average citations per item = 57.27) and UNIV WURZBURG (Publications = 18, H index = 15, average citations per item = 47.5) are influential institutions in the field of COM. The results of co-occurrence analysis show that the field of COM can be roughly divided into the following five modules: COM surgical research, COM basic research, COM diagnosis-related research, chronic recurrent multifocal osteomyelitis (CRMO)-related research, risk factors of COM. Risk factors of COM are the module with the highest concentration of hot words.
    CONCLUSION: COM-related research will continue to develop further in the next decade. The diagnosis research and risk factors of COM are the most popular research modules in recent years. Some controversial or troubled issues including the efficacy of perforator flap and fascia flap covering soft tissue, searching exclusive detection methods for the diagnosis of COM and bisphosphonates and biological agents in the treatment of CRMO may lead to the development of the COM field.
    Keywords:  chronic osteomyelitis; future hotspot; research status; visualization
    DOI:  https://doi.org/10.1111/os.13512
  12. Educ Inf Technol (Dordr). 2022 Oct 15. 1-28
      This study presents topic modeling based bibliometric characteristics of the articles related to the flipped classroom. The corpus of the study consists of 2959 articles published in the Scopus database as of the end of 2021. In addition to the bibliometric characteristics of the field, research interests and trends were also revealed with the study, which was based on the topic modeling-based bibliometric analysis method. According to the results of the study, an increase in the number of publications has been observed since 2015. Nearly one-third of the studies are of United States origin. According to the findings of the topic analysis in which the research interests and trends in the studies were revealed, the articles in this field were gathered under 16 topics. Considering the number of publications of the topic, it was seen that the three most voluminous topics were "Performance and perception", "Nursing education" and "Effectiveness and motivation", respectively. It is thought that the results of the study will provide a general perspective to the researchers in this field and provide important outputs in the context of monitoring the issues that may become prominent in the future.
    Keywords:  Data science in education; Flipped classroom; Research trends; Text mining; Topic modeling
    DOI:  https://doi.org/10.1007/s10639-022-11396-8
  13. Front Immunol. 2022 ;13 1013498
      Background: Macrophages significantly contributes to symptomology and structural progression of osteoarthritis (OA) and raise increasing attention in the relative research field. Recent studies have shown that tremendous progress has been made in the research of macrophages associated with osteoarthritis. However, a comprehensive bibliometric analysis is lacking in this research field. This study aimed to introduce the research status as well as hotspots and explore the field of macrophages research in OA from a bibliometric perspective.Methods: This study collected 1481 records of macrophages associated with osteoarthritis from 1991 to 2021 in the web of science core collection (WoSCC) database. CiteSpace, VOSviewer, and R package "bibliometrix" software were used to analyze regions, institutions, journals, authors, and keywords to predict the latest trends in macrophages associated with osteoarthritis research.
    Results: The number of publications related to macrophages associated with osteoarthritis is increasing annually. China and the USA, contributing more than 44% of publications, were the main drivers for research in this field. League of European Research Universities was the most active institution and contributed the most publications. Arthritis and Rheumatism is the most popular journal in this field with the largest publications, while Osteoarthritis and Cartilage is the most co-cited journal. Koch AE was the most prolific writer, while Bondeson J was the most commonly co-cited author. "Rheumatology", "Orthopedics", and "Immunology" were the most widely well-represented research areas of OA associated macrophages. "Rheumatoid arthritis research", "clinical symptoms", "regeneration research", "mechanism research", "pathological features", and "surgery research" are the primary keywords clusters in this field.
    Conclusion: This is the first bibliometric study comprehensively mapped out the knowledge structure and development trends in the research field of macrophages associated with osteoarthritis in recent 30 years. The results comprehensively summarize and identify the research frontiers which will provide a reference for scholars studying macrophages associated with osteoarthritis.
    Keywords:  CiteSpace; VOSviewer; bibliometric; macrophages; osteoarthritis
    DOI:  https://doi.org/10.3389/fimmu.2022.1013498
  14. Front Pharmacol. 2022 ;13 971113
      Background: Here, a bibliometric and knowledge-map analysis was used to analyze the research status and application of herbal medicine for the treatment of chronic kidney disease (CKD). By looking for research hotspots and key topics, we provide new clues and research directions for future research. Methods: Articles and reviews regarding herbal medicine in the treatment of CKD were retrieved from the Web of Science Core Collection on 23 May 2022. The R-bibliometrix, VOSviewer, and CiteSpace software were used to conduct the bibliometric and knowledge-map analysis. Results: In total, 5,920 authors at 1,330 institutions from 68 countries published 1,602 papers in 355 academic journals. China is the leader and pioneer in the research and application of herbal medicine in the field of CKD treatment. Beijing University of Chinese Medicine contributed the most publications. Ping Li (China-Japan Friendship Hospital) published the most articles, while Yingyong Zhao (Northwest University) had the most cocitations. However, cooperation among countries and the research institutions is not sufficient. Journal of Ethnopharmacology published the most research and application of herbal medicine in the treatment of CKD and was the most commonly co-cited journal. The most influential research hotspots about herbal medicine in the treatment of CKD focused on diabetic nephropathy-related research, Balkan endemic nephropathy, and pharmacokinetic study. Conclusion: Herbal medicine has a wide range of pharmacological activities and therapeutic value. The research and application of herbal medicine for the treatment of CKD, especially diabetic nephropathy, will remain a hot topic in the future.
    Keywords:  bibliometrics; chronic kidney disease; herbal medicine; hotspots; research status
    DOI:  https://doi.org/10.3389/fphar.2022.971113
  15. Front Pediatr. 2022 ;10 911293
      Background: In recent years, Allergic Rhinitis (AR) in children has caused widespread public concern. However, there are few studies concerning the overall trends in AR research in children based on bibliometric analysis.Objective: This study aims to explore hotspots and emerging trends in AR in children.
    Methods: The relevant publications were searched for in the Web of Science (WOS) Core Collection on December 31, 2021. The searched studies were exported to CiteSpace and Microsoft Excel for further visualized analysis.
    Results: In total, 649 articles were included. The number of publications related to AR in children has increased steadily in the last 20 years. Giorgio Ciprandi from Italy has the most articles and the leading countries were China and the USA. Guangzhou Medical University in China and Hallym University in Korea were the institutions with the most articles. The high-frequency keywords included AR, asthma, children, prevalence, and symptoms. Pathogenesis, comorbidity, epidemiology, symptoms, and therapy of AR in children are research hotspots.
    Conclusion: Over the past 20 years, research on AR in children has gradually improved. Visualization analysis indicates that pathogenesis, comorbidity, epidemiology, symptoms, and therapy are research hotspots, and immunotherapy and severity are probably the main research directions.
    Keywords:  CiteSpace; allergic rhinitis; children; visualization analysis; web of science
    DOI:  https://doi.org/10.3389/fped.2022.911293
  16. Am J Transl Res. 2022 ;14(9): 6467-6483
      Yes-associated protein 1 (YAP1) is a transcriptional coactivator that mediates the Hippo signaling pathway, which participates in the development and growth of the body; it plays key roles in tumorigenesis, metastasis, and therapy resistance. However, the pathophysiological mechanism of YAP1 has not been fully elucidated. Therefore, we explored the status and evolutionary trend in YAP1 research via bibliometric analysis. A total of 2,928 publications were downloaded from Web of Science Core Collection (WOSCC). The co-citation network map was drawn via CiteSpace and VOSviewer software. We analyzed the co-authorship networks among countries, journals, and authors, as well as co-occurrence of co-cited references, citation bursts, and keywords in YAP1 research, in order to predict its literature development. The present research evaluates the annual publication trends of YAP1 literature, and the following results were established: research on YAP1 are of steady increase; China present the highest co-citation; the Journal of Biological Chemistry (J Biol Chem) was the most productive journal, while Cell press received the most citations from co-cited references; Among the authors in the overall citations Bin Zhao is the most promising collaborator for emerging scholars in this field; and lastly, co-occurrence keyword analysis indicated that the emerging trends in YAP1 research were mainly focused on cancer therapy. We established that projects on YAP1 research is presently in its rapid developmental stage with active global collaboration. In addition, the mechanism and clinical significance of YAP1 in cancer was established as the potential trend of future studies.
    Keywords:  CiteSpace; VOSviewer; YAP1; bibliometric analysis; citation burstiness; hippo signaling pathway
  17. Front Oncol. 2022 ;12 926025
      Background: Glioma stem cells (GSCs) are a sub-population of cancer stem cells with capacity of self-renewal and differentiation. Accumulated evidence has revealed that GSCs were shown to contribute to gliomagenesis, distant metastasis as well as the resistance to radiotherapy and chemotherapy. As a result, GSCs were regarded as a promising therapeutic target in human glioma. The purpose of our study is to identify current state and hotspots of GSCs research by analyzing scientific publications through bibliometric methods.Methods: All relevant publications on GSCs during 2003-2021 were extracted from the Science Citation Index Expanded of Web of Science Core Collection (WoSCC), and related information was collected and analyzed using Microsoft Excel 2016, GraphPad Prism 8 and VOSviewer software.
    Results: A total of 4990 papers were included. The United States accounted for the largest number of publications (1852), the second average citations per item (ACI) value (67.54) as well as the highest H-index (157). Cancer Research was the most influential journal in this field. The most contributive institution was League of European Research Universities. RICH JN was the author with the most publications (109) and the highest H-index (59). All studies were clustered into 3 groups: "glioma stem cell properties", "cell biological properties" and "oncology therapy". The keywords "identification", "CD133" and "side population" appeared earlier with the smaller average appearing years (AAY), and the keywords"radiotherapy" and "chemotherapy" had the latest AAY. The analysis of top cited articles showed that "temozolomide", "epithelial-mesenchymal transition", and "immunotherapy" emerged as new focused issues.
    Conclusion: There has been a growing number of researches on GSCs. The United States has always been a leading player in this domain. In general, the research focus has gradually shifted from basic cellular biology to the solutions of clinical concerns. "Temozolomide resistance", "epithelial-mesenchymal transition", and "immunotherapy" should be given more attention in the future.
    Keywords:  EMT - epithelial to mesenchymal transformation; bibliometric analysis; chemotherapy resistance; glioma stem cell (GSC); hotpots
    DOI:  https://doi.org/10.3389/fonc.2022.926025
  18. Front Pharmacol. 2022 ;13 916871
      Objective: Asthma drug research has been increasing yearly, and its clinical application value has increasingly attracted attention. This study aimed to analyze the development status, research hotspots, research frontiers, and future development trends of the research works on drugs for patients with asthma, especially severe asthma. Methods: Asthma drug-related articles published between 1982 and 2021 were retrieved from the Web of Science Core Collection (WOSCC) database, and only articles published in English were included. CiteSpace and VOSviewer software were utilized to conduct collaborative network analysis of countries/regions, institutions, keywords, and co-citation analysis of references. Results: A total of 3,234 asthma drug-related eligible articles were included. The United States was in a leading position, and Karolinska Institute (Sweden) was the most active institution. The most prolific journal in this field was Journal of Asthma, and the most cited journal was Journal of Allergy and Clinical Immunology. Keyword co-occurrence studies suggested that the current hotspots and frontiers were as follows: ① asthma: fully revealing the potential of existing conventional asthma drugs, determining the best drug delivery system, and indicating the best combination. To continue to explore potential targets for severe asthma or other phenotypes. Inhaled glucocorticoids and budesonide are still one of the important aspects of current asthma drug research and ② severe asthma: the research and development of new drugs, especially monoclonal antibodies including omalizumab, mepolizumab, and benralizumab to improve asthma control and drug safety, have become a research hotspot in recent years, highlighting the importance of "target" selection. Conclusion: This study demonstrates the global research hotspots and trends of the research works on drugs for patients with asthma/severe asthma. It can help scholars quickly understand the current status and hotspots of research in this field.
    Keywords:  asthma; bibliometric analysis; drug; hotspots and frontiers; severe asthma
    DOI:  https://doi.org/10.3389/fphar.2022.916871
  19. J Korean Med Sci. 2022 Oct 17. 37(40): e296
      BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has resulted in enormous related publications. However, the citation frequency of these documents and their influence on the journal impact factor (JIF) are not well examined. We aimed to evaluate the impact of COVID-19 on biomedical research publications and their citation frequency.METHODS: We searched publications on biomedical research in the Web of Science using the search terms "COVID-19," "SARS-Cov-2," "2019 corona*," "corona virus disease 2019," "coronavirus disease 2019," "novel coronavirus infection" and "2019-ncov." The top 200 journals were defined as those with a higher number of COVID-19 publications than other journals in 2020. The COVID-19 impact ratio was calculated as the ratio of the average number of citations per item in 2021 to the JIF for 2020.
    RESULTS: The average number of citations for the top 200 journals in 2021, per item published in 2020, was 25.7 (range, 0-270). The average COVID-19 impact ratio was 3.84 (range, 0.26-16.58) for 197 journals that recorded the JIF for 2020. The average JIF ratio for the top 197 journals including the JIFs for 2020 and 2021 was 1.77 (range, 0.68-8.89). The COVID-19 impact ratio significantly correlated with the JIF ratio (r = 0.403, P = 0.010). Twenty-five Korean journals with a COVID-19 impact ratio > 1.5 demonstrated a higher JIF ratio (1.31 ± 0.39 vs. 1.01 ± 0.18, P < 0.001) than 33 Korean journals with a lower COVID-19 impact ratio.
    CONCLUSION: COVID-19 pandemic infection has significantly impacted the trends in biomedical research and the citation of related publications.
    Keywords:  COVID-19; Citation; Impact Factor; Journal; Publication; Research
    DOI:  https://doi.org/10.3346/jkms.2022.37.e296
  20. Front Oncol. 2022 ;12 854927
      Objective: In recent years, among the available tools, the concurrent application of Artificial Intelligence (AI) has improved the diagnostic performance of breast cancer screening. In this context, the present study intends to provide a comprehensive overview of the evolution of AI for breast cancer diagnosis and prognosis research using bibliometric analysis.Methodology: Therefore, in the present study, relevant peer-reviewed research articles published from 2000 to 2021 were downloaded from the Scopus and Web of Science (WOS) databases and later quantitatively analyzed and visualized using Bibliometrix (R package). Finally, open challenges areas were identified for future research work.
    Results: The present study revealed that the number of literature studies published in AI for breast cancer detection and survival prediction has increased from 12 to 546 between the years 2000 to 2021. The United States of America (USA), the Republic of China, and India are the most productive publication-wise in this field. Furthermore, the USA leads in terms of the total citations; however, hungry and Holland take the lead positions in average citations per year. Wang J is the most productive author, and Zhan J is the most relevant author in this field. Stanford University in the USA is the most relevant affiliation by the number of published articles. The top 10 most relevant sources are Q1 journals with PLOS ONE and computer in Biology and Medicine are the leading journals in this field. The most trending topics related to our study, transfer learning and deep learning, were identified.
    Conclusion: The present findings provide insight and research directions for policymakers and academic researchers for future collaboration and research in AI for breast cancer patients.
    Keywords:  Bibliometrix analysis; artificial intelligence; breast cancer; diagnosis and prognosis; knowledge structures
    DOI:  https://doi.org/10.3389/fonc.2022.854927
  21. J Interprof Care. 2022 Oct 20. 1-8
      Team science refers to research initiatives considered in collaboration with scientists from different disciplines or fields. This paper presents a bibliometric analysis for visualization of global research activity concerning the combination of cancer and the COVID-19 pandemic using a team science approach. A bibliometric study was implemented using Web of Science from 2019 to 2021. We analyzed citations to identify description and citations analysis of results, most prolific countries, international research collaboration, most prolific institutions, research areas, most cited papers, and most productive journals. The preliminary data of 2,313 studies that adopted a team science approach were recorded and analyzed. Team science is becoming progressively popular in cancer research. The United States was the most active country, followed by Italy and China. The United States, the United Kingdom, and Italy had the highest level of cooperation with other countries. The most prolific institution was Harvard University, followed by University of London and the University of Texas System. Head and Neck Journal for the Sciences and Specialties of the Head and Neck, Frontiers in Oncology, and eCancerMedicalScience were the most productive journals. Governments, organizations, policymakers, and researchers should pay attention to team science approach at times of disasters such as cancer and COVID-19 to achieve the best strategies for controlling cancer that is currently a world problem.
    Keywords:  Bibliometric analysis; COVID-19; cancer; interdisciplinary research; team science
    DOI:  https://doi.org/10.1080/13561820.2022.2115986
  22. Front Microbiol. 2022 ;13 1011050
      Background: Over the past 20 years, evidence has suggested that gut microbiota plays an important role in metabolic homeostasis. The relationship between gut microbiota and diabetes has become the focus of considerable scientific interest. With the sharp increase in publications in this area, it is imperative to analyze the relevant articles using bibliometrics methods.Methods: Publications on "the gut microbiota and diabetes" were retrieved and downloaded from the Web of Science Core Collection database. Microsoft Excel 2020, VOSviewer, CiteSpace 5.8.R3 and Co-Occurrence 9.94 software were used for data analysis and visualization. Country/academic institution, journal, author, subject category, keyword and reference were analyzed thoroughly. The cutting-edge directions in this field were also determined by analyzing keywords and key articles.
    Results: A total of 2,342 documents were included in the analysis; the number of articles in this field has increased yearly, particularly after 2010. China and the University of Copenhagen are the country and research institution associated with the largest number of publications. Nutrients have published 191 articles in this field, ranking first among highly productive journals in the number of publications. The researcher Cani PD affiliated with the University of Leuven, Belgium, published the greatest number of articles in this field between 2001 and 2021 and was also ranked as the first co-cited author and the largest contributor of highly cited papers in this field. Endocrinology & Metabolism was the most common subject category. Three of the most frequently found keywords, besides terms related to "microbiota" and "diabetes," were "obesity," "probiotics," and "inflammation." Akkermansia muciniphila, Faecalibacterium prausnitzii, trimethylamine n-oxide and branched-chain amino acids are intestinal bacteria or metabolites that have attracted more attention in recent years. Natural products represented by Chinese herbal medicine and some protein receptors or signaling pathways such as aryl hydrocarbon receptor, farnesoid X receptor and AMP-activated protein kinase were frontiers in this field.
    Conclusion: Over the past two decades, the rapid development of research on the gut microbiota has deepened the understanding of the physiology and pathology of diabetes, providing new insights into different approaches to treatment. In the future, further interdisciplinary innovation, clinical transformation, and application may receive more attention.
    Keywords:  bibliometrics; diabetes; gut microbiota; research trend; visualization
    DOI:  https://doi.org/10.3389/fmicb.2022.1011050
  23. SAGE Open Nurs. 2022 Jan-Dec;8:8 23779608221132164
      Background: To delineate the scientific publications on metal hypersensitivity. Methods: Scopus database from 1946 to 2020, written in English, Spanish, or Portuguese. This is a bibliometric study, with a descriptive and quantitative approach. For data analysis, we used RStudio® and VOSviewer® and bibliometric packages-bibliometrix and biblioshiny. Results: Of the 804 articles retrieved, most of the publications come from European, Asian, and American countries, with Germany, Japan, and United States leading. Published articles and keywords refer to orthopedic, dermatological, and orthodontic specialties. Conclusion: Scientific production is scarce with slight oscillations in the studied period, authored predominantly by researchers in North America and Europe. Articles were mostly published in scientific journals in the fields of dermatology, dentistry, and orthopedics, which indicated the need for greater investments in the research development on the topic.
    Keywords:  adverse effects; allergy; bibliometric literature review; hypersensitivity; metals
    DOI:  https://doi.org/10.1177/23779608221132164
  24. J Med Internet Res. 2021 Jul 05. 23(7): e25700
      BACKGROUND: Modern neurosurgery is a relatively young discipline characterized by finesse and complexity. In recent years, neurosurgery in China has made continuous developments, with long-term progress and outstanding discoveries in many aspects of the field.OBJECTIVE: This scientometric investigation aimed to comprehensively provide insight into the development trends of neurosurgery in China, to demonstrate how the field has evolved.
    METHODS: PubMed database was searched to retrieve relevant papers published between 1988 and 2018 from neurosurgery institutions in China. The database of the National Natural Science Foundation of China was also retrieved for funding information. Information (eg, year of publication, journal, institute of origin) and keywords were collected from each paper after removing duplicates and filtering unintentional words. Co-word analysis was performed on the papers' keywords, and a time distribution matrix of coexisting keywords in a given paper (ie, termed co-words) was established. Co-words were clustered according to their growth rate within years and visually presented with a mountain plot and a heatmap. Trends and potential subspecialties were identified, and each topic, represented either by a co-word from publications or funding from the National Natural Science Foundation of China during the period from 2011 to 2018, was collected and analyzed.
    RESULTS: Within 15,972 publications on neurosurgery from institutions in China, diagnostic image was found to coexist the most with other keywords. Cluster 0, represented by diagnostic image with retrospective study, contained emerging topics with great developmental potential and demonstrated high growth rates in recent years. This finding suggests that the topics represented in Cluster 0 may represent future areas of important neurosurgical research. We also found that the developmental trend of China's neurosurgical research is highly correlated with National Natural Science Foundation of China funding acquisition.
    CONCLUSIONS: Co-word analysis and visualization results provided insight into the emerging research topics that are of vital importance, which can be used as a reference by neurosurgeons and researchers for future investigations. In this study, our analysis strategy based on co-word biclustering was able to clearly demonstrate current academic subject development; therefore, co-word biclustering is a reliable bibliometric analysis strategy.
    Keywords:  bibliometric analysis; co-word biclustering analysis; neurosurgery; visualized analysis
    DOI:  https://doi.org/10.2196/25700
  25. JMIR Serious Games. 2022 Oct 19. 10(4): e38315
      BACKGROUND: In recent years, with the development of computer science and medical science, virtual reality (VR) technology has become a promising tool for improving cognitive function. Research on VR-based cognitive training has garnered increasing attention.OBJECTIVE: This study aimed to investigate the application status, research hot spots, and emerging trends of VR in cognitive rehabilitation over the past 20 years.
    METHODS: Articles on VR-based cognitive rehabilitation from 2001 to 2021 were retrieved from the Web of Science Core Collection. CiteSpace software was used for the visual analysis of authors and countries or regions, and Scimago Graphica software was used for the geographic visualization of published countries or regions. Keywords were clustered using the gCLUTO software.
    RESULTS: A total of 1259 papers were included. In recent years, research on the application of VR in cognitive rehabilitation has been widely conducted, and the annual publication of relevant literature has shown a positive trend. The main research areas include neuroscience and neurology, psychology, computer science, and rehabilitation. The United States ranked first with 328 papers, and Italy ranked second with 140 papers. Giuseppe Riva, an Italian academic, was the most prolific author with 29 publications. The most frequently cited reference was "Using Reality to Characterize Episodic Memory Profiles in Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Influence of Active and Passive Encoding." The most common keywords used by researchers include "virtual reality," "cognition," "rehabilitation," "performance," and "older adult." The largest source of research funding is from the public sector in the United States.
    CONCLUSIONS: The bibliometric analysis provided an overview of the application of VR in cognitive rehabilitation. VR-based cognitive rehabilitation can be integrated into multiple disciplines. We conclude that, in the context of the COVID-19 pandemic, the development of VR-based telerehabilitation is crucial, and there are still many problems that need to be addressed, such as the lack of consensus on treatment methods and the existence of safety hazards.
    Keywords:  CiteSpace; bibliometric analysis; cognitive disorder; cognitive rehabilitation; gCLUTO; rehabilitation; virtual reality; visual content analysis
    DOI:  https://doi.org/10.2196/38315
  26. Am J Sports Med. 2022 Oct 19. 3635465221124885
      BACKGROUND: To better understand the research impact on social media, alternative web-based metrics (Altmetrics) were developed. Open access (OA) publishing, which allows for widespread distribution of scientific content, has become increasingly common in the medical literature. However, the relationship between OA publishing and social media impact remains unclear.PURPOSE: To compare social media attention and citation rates between OA and subscription access (SA) research articles within the orthopaedic and sports medicine literature.
    STUDY DESIGN: Cross-sectional study.
    METHODS: Articles published as either OA or SA in 5 high-impact hybrid orthopaedic journals between January 2019 and December 2019 were analyzed. The primary outcome was the Altmetric Attention Score (AAS), a validated measure of social media attention. Secondary outcomes included citation rates, article characteristics, and the number of shares on social media. Independent t tests and chi-square analyses were used to compare outcomes between OA and SA articles. A multivariable linear regression analysis was performed to determine the association between article type and AAS while controlling for bibliometric characteristics.
    RESULTS: A total of 2143 articles (246 OA articles, 11.5%; 1897 SA articles, 88.5%) were included. The mean AAS among all OA articles was 62.4 ± 184.6 (range, 0-2032), whereas the mean AAS among all SA articles was 18.4 ± 109.8 (range, 0-3425), representing a statistically significant difference (P < .001). The mean citation rate among OA articles was significantly higher (17.0 ± 22.5; range, 0-139) than that of SA articles (8.6 ± 13.4; range, 0-169) (P < .001). Multivariable linear regression analysis demonstrated that OA status (β = 15.15; P = .044), number of institutions (β = 2.13; P = .023), studies classified as epidemiological investigations (β = 107.40; P < .001), and disclosure of a conflict of interest (β = -11.18; P = .032) were significantly associated with a higher AAS.
    CONCLUSION: OA articles resulted in significantly greater AAS and citations in comparison with SA articles. Articles published through the OA option in hybrid journals as well as those with a higher number of institutions, those that disclosed a conflict of interest, and those classified as epidemiological investigations were positively associated with greater AAS in addition to a greater number of citations. The potential for more extensive research dissemination inherent in the OA option may therefore translate into greater reach and social media attention.
    Keywords:  Altmetrics; impact; open access; orthopaedics; social media; visualization
    DOI:  https://doi.org/10.1177/03635465221124885
  27. Front Bioeng Biotechnol. 2022 ;10 1030377
      Objective: Two-photon polymerization (TPP) utilizes an optical nonlinear absorption process to initiate the polymerization of photopolymerizable materials. To date, it is the only technique capable of fabricating complex 3D microstructures with finely adjusted geometry on the cell and sub-cell scales. TPP shows a very promising potential in biomedical applications related to high-resolution features, including drug delivery, tissue engineering, microfluidic devices, and so forth. Therefore, it is of high significance to grasp the global scientific achievements in this field. An analysis of publications concerning the applications of TPP in the biomedical field was performed, and the knowledge domain, research hotspots, frontiers, and research directions in this topic were identified according to the research results. Methods: The publications concerning TPP applications in biomedical field were retrieved from WoSCC between 2003 and 2022, Bibliometrics and visual analysis employing CiteSpace software and R-language package Bibliometrix were performed in this study. Results: A total of 415 publications regarding the TPP applications in the biomedical field were retrieved from WoSCC, including 377 articles, and 38 review articles. The studies pertaining to the biomedical applications of TPP began back in 2003 and showed an upward trend constantly. Especially in the recent 5 years, studies of TPP in biomedical field have increased rapidly, with the number of publications from 2017 to 2021 accounting for 52.29% of the total. In terms of output, China was the leading country and Chinese Acad Sci, Tech Inst Phys and Chem was the leading institution. The United States showed the closest cooperation with other countries. ACS applied materials and interfaces was the most prolific journal (n = 13), followed by Biofabrication (n = 11) and Optics express (n = 10). The journals having the top cited papers were Biomaterials, Advanced materials, and Applied physic letters. The most productive author was Aleksandr Ovsianikov (27 articles). Meanwhile, researchers who had close cooperation with other researchers were also prolific authors. "cell behavior", " (tissue engineering) scaffolds", "biomaterials," and "hydrogel" were the main co-occurrence keywords and "additional manufacturing", "3D printing," and "microstructures" were the recent burst keywords. The Keyword clusters, "stem cells," and "mucosal delivery", appeared recently. A paper reporting unprecedented high-resolution bull models fabricated by TPP was the most locally cited reference (cited 60 times). "Magnetic actuation" and "additive manufacturing" were recently co-cited reference clusters and an article concerning ultracompact compound lens systems manufactured by TPP was the latest burst reference. Conclusion: The applications of TPP in biomedical field is an interdisciplinary research topic and the development of this field requires the active collaboration of researchers and experts from all relevant disciplines. Bringing up a better utilization of TPP as an additive manufacturing technology to better serve the biomedical development has always been the research focus in this field. Research on stem cells behaviors and mucosal delivery based on microstructures fabricated using TPP were becoming new hotspots. And it can be predicted that using TPP as a sourcing technique to fabricate biomedical-related structures and devices is a new research direction. In addition, the research of functional polymers, such as magnetic-driven polymers, was the frontier topic of TPP biomedical applications.
    Keywords:  bibliometrics; bibliometrix; biomedical; citespace; photopolymerization; two-photon; visualized
    DOI:  https://doi.org/10.3389/fbioe.2022.1030377
  28. Anesth Analg. 2022 Nov 01. 135(5): 1011-1020
      The continued citation of retracted publications from the medical literature is a well-known and persistent problem. We describe the contexts of ongoing citations to manuscripts that have been retracted from a selection of anesthesiology journals. We also examine how bibliographic databases and publisher websites document the retracted status of these manuscripts. The authors performed an analysis of retracted publications from anesthesiology journals using the Retraction Watch database. We then examined how the retraction information was displayed on bibliographic databases, search engines, and publisher websites. The primary outcome was the context of continued citation after retraction of flawed publications within the specialty of anesthesiology. Secondary outcomes included comparison of the documentation, bibliographic databases, search engines, and publisher websites used in identifying the retracted status of these publications and provision of access to the respective retraction notices. A total of 245 original publications were retracted over a 28-year period from 9 anesthesiology journals. PubMed, compared to the other databases and search engines, was the most consistent (98.8%) in documenting the retracted status of the publications examined, as well as providing a direct link to the retraction notice. From the 211 publications retracted before January 2020, there were 1307 postretraction citations accessed from Scopus. The median number of postretraction citations was 3.5 (range, 0-88, with at least 1 citation in 164 publications) in Scopus. Of the postretraction citations, 80% affirmed the validity of the retracted publications, while only 5.2% of citations acknowledged the retraction or misconduct. In 10.2% of the citations from original research studies, retracted manuscripts appeared to influence the decision to pursue or the methods used in subsequent original research studies. The frequency of citation of the 15 most cited retracted publications declined in a similar pattern during the 10 years after retraction. Citation of manuscripts retracted from anesthesiology journals remains a common occurrence. Technological innovations and application of standards for handling retracted publications, as suggested by coalitions of researchers across the spectrum of scientific investigation, may serve to reduce the persistence of this error.
    DOI:  https://doi.org/10.1213/ANE.0000000000006195
  29. Iran J Public Health. 2022 Jul;51(7): 1568-1575
      Background: Microscopy is a resource used in endodontics as an aid in the study of pulp and periapical pathologies; it has allowed Endodontics to become more accurate, less invasive and has enabled greater chances of success in treatment. We aimed to map the scientific production on "microscopy" and "endodontics" in the databases, the ISI Web of Knowledge/Web of Science tm.Methods: This bibliometric survey was conducted using ISI Web of Knowledge/Web of Science database, in the time frame between the years 1945 and 2016, the first being found in 1981.
    Results: Overall, 287 articles were identified. These articles are published in 63 different journals and were written by 1145 authors who have links to 336 institutions, located in 46 countries. To achieve these articles, 5,668 references were used, with an average of approximately 20 references per article. In the national literature the number of studies on the subject is broad compared to the international literature.
    Conclusion: The bibliometric review showed the potential of microscopy in clinical practice, the continuity of the investigation, in view of the need to expand knowledge on the topic that remains relevant.
    Keywords:  Bibliometrics; Endodontics; Microscopy
    DOI:  https://doi.org/10.18502/ijph.v51i7.10090
  30. Arch Dermatol Res. 2022 Oct 21.
      Research productivity is one criterion used by residency programs to evaluate the academic qualifications of prospective applicants. Our objective was to examine individuals' research productivity in dermatology residency compared to medical school. A cohort of dermatology residents who graduated from an Accreditation Council for Graduate Medical Education (ACGME) certified Dermatology program in 2019 or 2020. An author search was conducted to identify author publications. Author number, journal name, impact factor, study type, and publication date were collected. Publications were characterized as pre-residency publications (PRPs) if published during intern year, medical school graduating year, or the year before graduating year. Publications were residency publications (RPs) if published during residency. A Wilcoxon signed-rank test was used to compare the average number of PRPs and RPs between individuals. Secondary outcomes were compared using chi-square and t-tests. 55159 publications were collected. There was no difference in mean number of PRPs and RPs. However, PRPs were more likely to be first author publications and RPs were more likely to be case reports. Both PRPs and RPs were generally published in the same journals. The differences in PRPs and RPs may stem from changes in mentorship/sponsorship roles during training. Our findings add to the literature on PRPs. Future research should examine continued trends of publications in residency and fellowship.
    Keywords:  Graduate medical education; Research productivity
    DOI:  https://doi.org/10.1007/s00403-022-02418-z
  31. Environ Sci Pollut Res Int. 2022 Oct 20.
      With the emergence of environmental issues regarding persistent organic pollutants (POPs), fugacity models have been widely used in the concentration prediction and exposure assessment of POPs. Based on 778 relevant research articles published between 1979 and 2020 in the Web of Science Core Collection (WOSCC), the current research progress of the fugacity model on predicting the fate and transportation of POPs in the environment was analyzed by CiteSpace software. The results showed that the research subject has low interdisciplinarity, mainly involving environmental science and environmental engineering. The USA was the most paper-published country, followed by Canada and China. The publications of the Chinese Academy of Sciences, Lancaster University, and Environment Canada were leading. Collaboration between institutions was inactive and low intensity. Keyword co-occurrence analysis showed that polychlorinated biphenyls, organochlorine pesticides, and polycyclic aromatic hydrocarbons were the most concerning compounds, while air, water, soil, and sediment were the most concerning environmental media. Through co-citation cluster analysis, in addition to the in-depth exploration of traditional POPs, research on emerging POPs such as cyclic volatile methyl siloxane and dechlorane plus were new research frontiers. The distribution and transfer of POPs in the soil-air environment have attracted the most attention, and the regional grid model based on fugacity has been gradually improved and developed. The co-citation high-burst detection showed that the research hotspots gradually shifted from pollutant persistence and long-range transport potential to pollutant distribution rules among the different environmental media and the long-distance transmission simulation.
    Keywords:  Bibliometric analysis; CiteSpace; Co-citation cluster; Fugacity model; Multi-media model; Persistent organic pollutants
    DOI:  https://doi.org/10.1007/s11356-022-23397-8
  32. Int J Mycobacteriol. 2022 Jul-Sep;11(3):11(3): 249-255
      Background: Nowadays, tuberculosis and COVID-19 are the principal infections around the world. This study aimed to determine the global scientific production on COVID-19 associated to tuberculosis during the period 2019-2020.Methods: For the collection of metadata on COVID-19 associated to tuberculosis, the Scopus database was used, considering the period 2019-2020, with the last day of update being September 13, 2021. The main authors, countries, institutions, journal metrics, and documents were extracted. The Scival tool was used for the scientometric analysis of the data.
    Results: A total of 464 papers were retrieved where it was found that universities in South Africa, the United States, and England led the world's scientific production. The International Journal of Tuberculosis and Lung Disease was the journal with the highest production and The Lancet Global Health was the journal with the most citations per publication. On the other hand, most papers were published in Q1 journals, with infectious diseases within the area of medicine being the most addressed.
    Conclusion: South African universities lead the world in scientific output. Most of the research on this topic has been published in Q1 journals, with collaboration being largely national. Further analysis is needed in the aftermath of the pandemic.
    Keywords:  COVID-19; scientific production; scientometric; tuberculosis
    DOI:  https://doi.org/10.4103/ijmy.ijmy_81_22
  33. J Pain Res. 2022 ;15 3209-3222
      Background: Postoperative pain in children has been overlooked for a long time. The knowledge structure, research hotspots and trends related to postoperative pain in children are unclear and have not been systematically summarized.Purpose: We aimed to analyze the current state of research on postoperative pain in children and to conduct in-depth mining of the knowledge structure.
    Methods: The PubMed database for publications on postoperative pain in children between 1950 and 2021 was searched. Bibliographic Item Co-Occurrence Matrix Builder (BICOMB) was performed to obtain the co-word matrix and co-occurrence matrix. The H-index method was used to extract high-frequency main Medical Subject Headings (MeSH) terms/subheadings.
    Results: The high-frequency MeSH terms were analyzed by biclustering, strategic diagram and social network analyses. Totally, 4022 publications were retrieved. The analysis showed that 60 countries or regions published relevant documents, with the United States publishing the most significant number of papers. Totally, 811 journals published relevant papers, with Pediatric Anesthesia ranking first. Moreover, we extracted 43 high-frequency main MeSH terms/subheadings and clustered them into five categories: overview, aetiology and epidemiology, pharmacotherapy, opioid administration and dosing, and prevention and control of postoperative pain in children.
    Conclusion: Pharmacological treatments, pain prevention and control are the focus of research and are becoming increasingly mature. Opioid stewardship and regional anesthesia is the trend and focus of future research. Our study offers a better understanding of the current status and knowledge structure of postoperative pain in children and provides a reference for improving postoperative pain management in children in the future.
    Keywords:  bibliometrics; children; postoperative pain; status; trends; visualization analysis
    DOI:  https://doi.org/10.2147/JPR.S380842
  34. TechTrends. 2022 Oct 13. 1-17
      In recent years, publications on microlearning have substantially increased, as this topic has received extensive attention from scholars in the instructional design and technology discipline. To better characterize and understand microlearning, there is a need for comprehensive bibliometrics assessments of the literature on microlearning. To this end, this bibliometric study collected 208 relevant publications on microlearning from the Scopus database, published in diverse contexts. Using quantitative topic modeling and qualitative content analysis methods, we identified four major themes in these publications, namely: (1) design of microlearning; (2) implementation of microlearning as an instructional method strategy and an intervention; (3) evaluation of microlearning; and (4) the utilization of mobile devices for microlearning. Based on the study findings, we discuss the significance of the study and provide implications for research and practice, particularly in fostering rigorous inquiry on the topic of microlearning, expanding the context of research to include K-12 settings, and focusing on mobile-based microlearning.
    Keywords:  Bibliometrics; Instructional design and technology; Microlearning
    DOI:  https://doi.org/10.1007/s11528-022-00794-x
  35. J Exp Bot. 2022 Oct 22. pii: erac424. [Epub ahead of print]
      Plant transpiration is one of the main water flux components on the earth's land surface. Accurate measurement of plant transpiration is critical to better understand plant water use, to develop water management strategies, and to explore the influence of plants on regional and even global climate. At present, heat tracer based sap flow (HTSF) techniques are the dominant method to measure sap flow and then to estimate plant transpiration at the individual plant level. However, the majority of current research focuses on specific applications or the evaluation of the method itself, while the overall picture of the use of HTSF methods is lacking. The objectives of this study were two fold: (1) briefly review the theories and categories of various HTSP methods, and (2) investigate the use of HTSF methods in measuring plant transpiration using bibliometrics. The HTSF methods were divided into six transient and three steady-state techniques based on their governing theory. Each method was described mathematically and their applications and pros and cons were briefly discussed. The bibliometric analysis was conducted using 3,964 papers published between 1992 and 2020 archived in the Web of Science core collection. The number of articles published in this field has increased exponentially over the past three decades. The analysis identified the most productive authors, organizations, and countries, as well as the most utilized HTSF methods and journals in which the papers were published. USA, China, and Germany are the top three countries applying HTSF methods to measure transpiration. The thermal dissipation method is most widely used mainly because they are the most easily self-manufactured sensors as well as the availability of commercially-available sensors. Agricultural and Forest Meteorology, Tree Physiology, and Agricultural Water Management are the most widely utilized journals for publication of results. In addition, world distribution maps of the use of HTSF methods and tree species measured were drawn based on the 741 selected publications with in situ measurements.
    Keywords:  heat balance method; heat pulse method; heat ratio method; heat tracer-based sap flow (HTSF); scientometrics; thermal dissipation method
    DOI:  https://doi.org/10.1093/jxb/erac424
  36. Ann Med Surg (Lond). 2022 Oct;82 104678
    Colombian Future Surgeons Collaborative Group
      Introduction: The production of quality surgical evidence and the development of academic surgery have emerged as priorities for the solution of current barriers to achieving the objectives of global surgery. The academic training and scientific production of academic surgeons is essential for the production of new knowledge. In Latin America, specifically in Colombia, there are no studies that have analyzed this production.Methods: A retrospective cross-sectional bibliometric study was carried out, in which the Colombian Ministry of Science database was consulted with the validated results up to July 2021. In the search section for research profiles, the key word "Surgery" was used, and all associated CvLAC (profiles where the information of Colombian researchers can be found) and their registered products were reviewed.
    Results: A total of 1701 researchers in surgery were registered in the database of the Colombian Ministry of Science, of which only 380 corresponded to academic surgeons with correct registration. Only 6 (1.6%) were found to have a Ph.D., 45 (11.8%) a fellow, and 20 (5.3%) a master's degree. 79.5% (n = 302) of Colombian academic surgeons are men. Only 10.2% (n = 39) are formally categorized as researchers. 45.3% (n = 172) have not published scientific articles. The total number of published articles was 2386, and most of them were published in Q4 journals (n = 1121; 47%) or not indexed by SJR/Publindex (n = 517; 21.6%). Only 3 surgeons have more than 100 articles. 9.5% have published at least 1 book, and 40% have participated in at least 1 project.
    Conclusions: According to data registered with the Colombian Ministry of Science, a large part of the scientific production of Colombian academic surgeons is concentrated in scientific articles, most of which are found in Q4 or non-categorized journals. Approximately half of the academic surgeons have not published at least one scientific article. However, one fifth of those who have, have published at least 8 articles. Less than 20% of surgeons have additional postgraduate studies, and only 1 in 4 academic surgeons is a woman.
    Keywords:  Colombia; Curriculum; Evidence-based medicine; General surgery; Publishing; Research
    DOI:  https://doi.org/10.1016/j.amsu.2022.104678
  37. Medicine (Baltimore). 2022 Oct 14. 101(41): e31052
      BACKGROUND: A urinary tract infection (UTI) is one of the most common types of infections affecting the urinary tract. When bacteria enter the bladder or kidney and multiply in the urine, a URI can occur. The urethra is shorter in women than in men, which makes it easier for bacteria to reach the bladder or kidneys and cause infection. A comparison of the research differences between Urology and Nephrology (UN) authors regarding UTI pertaining to the 4 areas (i.e., Chronic Kidney Disease, Hemodialysis, Peritoneal Dialysis, and Renal Transplantation [CHPR]) is thus necessary. We propose and verify 2 hypotheses: CHPR-related articles on UTI have equal journal impact factors (JIFs) in research achievements (RAs) and UN authors have similar research features (RFs).METHODS: Based on keywords associated with UTI and CHPR in titles, subject areas, and abstracts since 2013, we obtained 1284 abstracts and their associated metadata (e.g., citations, authors, research institutes, departments, countries of origin) from the Web of Science core collection. There were 1030 corresponding and first (co-first) authors with hT-JIF-indices (i.e., JIF was computed using hT-index rather than citations as usual). The following 5 visualizations were used to present the author's RA: radar, Sankey, time-to-event, impact beam plot, and choropleth map. The forest plot was used to distinguish RFs by observing the proportional counts of keyword plus in Web of Science core collection between UN authors.
    RESULTS: It was observed that CHPR-related articles had unequal JIFs (χ2 = 13.08, P = .004, df = 3, n = 1030) and UN departments had different RFs (Q = 53.24, df = 29, P = .004). In terms of countries, institutes, departments, and authors, the United States (hT-JIF = 38.30), Mayo Clinic (12.9), Nephrology (19.14), and Diana Karpman (10.34) from Sweden had the highest hT-JIF index.
    CONCLUSION: With the aid of visualizations, the hT-JIF-index and keyword plus were demonstrated to assess RAs and distinguish RFs between UN authors. A replication of this study under other topics and in other disciplines is recommended in the future, rather than limiting it to UN authors only, as we did in this study.
    DOI:  https://doi.org/10.1097/MD.0000000000031052
  38. Scientometrics. 2022 Oct 10. 1-28
      Research is becoming increasingly accessible to the public via open access publications, researchers' social media postings, outreach activities, and popular disseminations. A healthy research discourse is typified by debates, disagreements, and diverging views. Consequently, readers may rely on the information available, such as publication reference attributes and bibliometric markers, to resolve conflicts. Yet, critical voices have warned about the uncritical and one-sided use of such information to assess research. In this study we wanted to get insight into how individuals without research training place trust in research based on clues present in publication references. A questionnaire was designed to probe respondents' perceptions of six publication attributes. A total of 148 students responded to the questionnaire of which 118 were undergraduate students (with limited experience and knowledge of research) and 27 were graduate students (with some knowledge and experience of research). The results showed that the respondents were mostly influenced by the number of citations and the recency of publication, while author names, publication type, and publication origin were less influential. There were few differences between undergraduate and graduate students, with the exception that undergraduate students more strongly favoured publications with multiple authors over publications with single authors. We discuss possible implications for teachers that incorporate research articles in their curriculum.
    Keywords:  Citations; Credibility; Post truths; Publication; References; Trust
    DOI:  https://doi.org/10.1007/s11192-022-04521-4
  39. Front Psychol. 2022 ;13 990663
      This study focuses on user experience from the perspective of big data to complete the aggregation, clustering, and visual presentation of knowledge. Using a combination of sample literature review, visualization technologies, knowledge map analysis, Carrot2 clustering, and other methodologies, this study intends to examine user experience from three perspectives: research state, hotspots, and trends. First, based on the double-map overlay, core institutions, core countries, core authors, core journals, and core references distribution research, the knowledge flow, research power, and research subjects of user experience are analyzed. Secondly, through keyword clustering analysis, this research intuitively presents the research topics of user experience and reveals the research hotspots and the evolution path of research methods. Finally, with the help of the subject clustering algorithm, the emerging trends of user experience research are predicted: the immersive experience upgrade of multi-scenario integration, the innovative design of multi-role collaboration, and the cross-disciplinary interactive exploration of multi-discipline. Following this, the user experience knowledge map is constructed, providing a global view and macro-cognition for subsequent research.
    Keywords:  Carrot2; CiteSpace; data visualization; knowledge map; user experience
    DOI:  https://doi.org/10.3389/fpsyg.2022.990663
  40. Acad Radiol. 2022 Oct 18. pii: S1076-6332(22)00511-6. [Epub ahead of print]
      RATIONALE AND OBJECTIVE: This study evaluates the association of h-index, a widely used bibliometric factor used to determine promotions and grant allocations, with academic ranking, sex, and geographic distribution in the interventional radiology community.MATERIALS AND METHODS: A database of all academic interventional radiologists in the US was created; academic rank, sex, institution, and geographic location were obtained. The Scopus database was used to determine the physicians' h-index.
    RESULTS: Our query identified 832 board-certified interventional radiologists. The mean h-index amongst all interventional radiologists was 10.81 ± 13.17 (median, 7; range, 0-167). H-indices were significantly different amongst assistant professors, associate professors, and professors (p < 0.0001). Our query identified 724 male interventional radiologists and 108 female interventional radiologists. The mean h-index amongst male interventional radiologists was 11.27 ± 13.69 (median, 7; range, 0-167) and amongst female interventional radiologists was 7.72 ± 8.33 (median, 5; range, 0-47). When stratified by rank, there was no statistically significant difference in h-index between male and female interventional radiologists. Multiple regression analysis identified sex is not significantly associated with h-index, but academic rank and region are.
    CONCLUSION: H-index in academic interventional radiology correlates significantly with faculty position and may be a factor in determining academic promotion. The sex-based differences in h-index seem to be due to the greater number of male faculty in senior academic positions who have been in the field for longer.
    Keywords:  Academic promotion; H-index; Interventional radiology; Research
    DOI:  https://doi.org/10.1016/j.acra.2022.09.020
  41. Front Pediatr. 2022 ;10 1019371
      Background: Asthma is one of the most common chronic diseases in children globally. In recent decades, advances have been made in understanding the mechanism, diagnosis, treatment and management for childhood asthma, but few studies have explored its knowledge structure and future interests comprehensively.Objective: This scientometric study aims to understand the research status and emerging trends of childhood asthma.
    Methods: CiteSpace (version 5.8.R3) was used to demonstrate national and institutional collaborations in childhood asthma, analyze research subjects and journal distribution, review research keywords and their clusters, as well as detect research bursts.
    Results: A total of 14,340 publications related to childhood asthma were extracted from Web of Science (core database) during January 2011 to December 2021. The results showed that academic activities of childhood asthma had increased steadily in the last decade. Most of the research was conducted by developed countries while China, as a developing country, was also actively engaged in this field. In addition to subjects of allergy and immunology, both public health aspects and ecological environmental impacts on the disease were emphasized recently in this research field. Keywords clustering analysis indicated that research on asthma management and atopy was constantly updated and became the two major research focuses recently, as a significant shift in research hotspots from etiology and diagnosis to atopic march and asthma management was identified. Subgroup analysis for childhood asthma management and atopy suggested that caregiver- or physician-based education and interventions were emerging directions for asthma management, and that asthma should be carefully studied in the context of atopy, together with other allergic diseases.
    Conclusions: This study presented a comprehensive and systematic overview of the research status of childhood asthma, provided clues to future research directions, and highlighted two significant research trends of asthma management and atopy in this field.
    Keywords:  asthma management; atopic march; bibliometrics analysis; childhood asthma; citespace; scientometric analysis
    DOI:  https://doi.org/10.3389/fped.2022.1019371
  42. iScience. 2022 Nov 18. 25(11): 105297
      Since early 2020, researchers have made efforts to study various issues related to cities and the pandemic. Despite the wealth of research on this topic, there are only a few review articles that explore multiple issues related to it. This is partly because of the rapid pace of publications that makes systematic literature review challenging. To address this issue, in the present study, we rely on bibliometric analysis techniques to gain an overview of the knowledge structure and map key themes and trends of research on cities and the pandemic. Results of the analysis of 2,799 articles show that research mainly focuses on six broad themes: air quality, meteorological factors, built environment factors, transportation, socio-economic disparities, and smart cities, with the first three being dominant. Based on the findings, we discuss major lessons that can be learned from the pandemic and highlight key areas that need further research.
    Keywords:  Environmental issues; human geography; urban planning
    DOI:  https://doi.org/10.1016/j.isci.2022.105297
  43. World Neurosurg. 2022 Oct 17. pii: S1878-8750(22)01460-7. [Epub ahead of print]
      BACKGROUND: Research serves to bolster clinical neurosurgery by critically assessing various disease pathologies, while identifying important challenges and opportunities. However, there is limited information on the landscape of the Ghanaian neurosurgical literature.METHODS: A scoping review and bibliometric analysis was conducted in accordance with PRISMA guidelines. PubMed, Embase, Global Index Medicus and Web of Science electronic databases were searched from inception until December 21, 2021 for English language articles about neurosurgery in Ghana.
    RESULTS: 927 articles were identified and 66 were ultimately included in the analysis. A majority of them, 42.4%, were retrospective cohort studies, with 62.1% published after 2010. There were no randomized controlled or basic science studies. Most articles were published in the West African Journal of Medicine (24.2%) and non-infectious/non-traumatic spinal pathology was the most commonly discussed topic (22.7%). 66.7% of articles included only authors affiliated with Ghanaian institutions and international collaborators frequently originated from the United States (15.9%). Only 22.7% of the manuscripts reported a funding source. Commonly reported challenges included limited sample sizes, delays in diagnosis and treatment and lack of proper diagnostic tools and specialized care.
    CONCLUSIONS: This review revealed that while the Ghanaian academic neurosurgery output has been increasing over time, these have been limited to cohort studies largely assessing spine pathology. The Ghanaian neurosurgical research environment may be bolstered by an increase in research funding, the establishment of longitudinal clinical databases, training in research methodology, increased incentives for researchers, strengthening of research collaborative networks and increased engagement of neurosurgical trainees in research.
    Keywords:  Ghana; bibliometrics; limited resources; low- and middle-income countries; neurosurgery; scoping review
    DOI:  https://doi.org/10.1016/j.wneu.2022.10.044
  44. PLoS One. 2022 ;17(10): e0275306
      In innovation strategy, a type of Schumpeterian competitive strategy in business administration, "intra-individual diversity" has attracted attention as one factor for creating innovation. In this study, we redefine "framework for identifying researchers' areas of expertise" as "a framework for quantifying intra-individual diversity among researchers. Note that diversity here refers to authorship of articles in multiple research fields. The application of this framework then made it possible to visualize organizational diversity by accumulating the intra-individual diversity of researchers and to discuss the innovation strategy of the organization. The analysis in this study discusses how countries are promoting research on the topics of artificial intelligence (AI), big data, and Internet of Things (IoT) technologies, which are at the core of Industry 4.0, from an innovation perspective. Note that Industry 4.0 is a technological framework that aims to "improve the efficiency of all social systems," "create new industries," and "increase intellectual productivity." For the analysis, we used 19-year bibliographic data (2000-2018) from the top 20 countries in terms of the number of papers in AI, big data, and IoT technologies. As the results, this study classified the styles of cross-disciplinary fusion into four patterns in AI and three patterns in big data. This study did not consider the results in IoT because of only small differences between countries. Furthermore, regional differences in the style of cross-disciplinary fusion were also observed, and the global innovation patterns in Industry 4.0 were classified into seven categories. In Europe and North America, the cross-disciplinary integration style was similar to that between the United States, Germany, the Netherlands, Spain, England, Italy, Canada, and France. In Asia, the cross-disciplinary fusion style was similar between China, Japan, and South Korea.
    DOI:  https://doi.org/10.1371/journal.pone.0275306
  45. JAMA Surg. 2022 Oct 19.
      Importance: Women have made substantial advancements in academic surgery, but research funding disparities continue to hamper their progress, and current literature on the status of National Institutes of Health (NIH) funding awarded to women surgeon-scientists appears to be conflicting.Objective: To examine gender-based differences in NIH funding awarded to surgeon-scientists by comparing total grant amounts awarded and the distribution of grants by gender and research type.
    Design, Setting, and Participants: This cross-sectional study was performed using a previously created database of NIH-funded surgeons from 2010 to 2020. Active physician data from the Association of American Medical Colleges were used to calculate total surgeon populations. This study was performed at the NIH using the NIH internal data platform, iSearch Grants. A total of 715 men and women surgeon-scientists funded by the NIH in 2010 and 1031 funded in 2020 were included in the analysis.
    Main Outcomes and Measures: The main outcome was the number of women among the total number of surgeons who received NIH grants and the total grant amounts awarded to them. Bivariate χ2 analyses were performed using population totals and substantiated by z tests of population proportions.
    Results: This study included 715 physicians (n = 579 men [81.0%]) in 2010 and 1031 physicians (n = 769 men [74.6%]) in 2020. In 2020, women comprised 27.4% of the surgical workforce and 25.4% of surgeons with research funding in the US, but they received only 21.7% of total NIH research funding awarded to all surgeons. The number of funded women surgeon-scientists, however, significantly increased from 2010 to 2020 (262 [25.4%] in 2020 vs 136 [19.0%] in 2010; P < .001) as did their funding ($189.7 million [21.7%] in 2020 vs $75.9 million [12.3%] in 2010; P < .001). Furthermore, the proportion of US women surgeons overall with NIH funding significantly increased in 2020 vs 2010 (0.7% vs 0.5%; P < .001). Basic science, clinical outcomes, and clinical trial R01 grants also increased among women surgeon-scientists. Women and men K grant holders had a similar mean (SD) number of R01 application attempts before success (2.7 [3.01] vs 2.3 [3.15]; P = .60) and similar K-to-R award conversion rates (23.5% vs 26.7%; P = .55).
    Conclusions and Relevance: This cross-sectional study found an increasing number of women surgeon-scientists receiving NIH funding in 2020 vs 2010 as well as increases in the median grant amounts awarded. Although these results are promising, a discrepancy remains in the proportion of women in the surgical workforce compared with those funded by the NIH and the total grant amounts awarded to them.
    DOI:  https://doi.org/10.1001/jamasurg.2022.5157
  46. Ann Clin Transl Neurol. 2022 Oct 19.
      OBJECTIVE: This research aims to examine the impact of the National Amyotrophic Lateral Sclerosis (ALS) Registry-funded research activities.METHODS: Registry-funded research and related publications were identified through the National ALS Registry website, the National Institutes of Health (NIH) Reporter website, and verified by Principal Investigators. Key study characteristics (e.g., study population, sample size) and key impact features (e.g., risk factors) were abstracted and recorded on study abstraction forms. Descriptive statistics were used to analyze the volume, productivity, and findings of the Registry-funded research.
    RESULTS: Since 2012, the National ALS Registry funded 21 research projects. Of these, 14 were through extramural research grants and included in the analysis. These studies are often related to environmental, medical conditions, and genetic risk factors. On average, the funded grants produced 1 to 2 publications which were cited 114 times by other researchers. The relative citation ratio averaged 1.81 with a weighted relative citation ratio of 16.28. These studies supported the identification and confirmation of candidate risk factors. Environmental and occupational risk factors typically related to heavy metal exposure (e.g., lead, mercury) and agricultural chemicals (e.g., pesticides, herbicides), and the occupations associated with exposure to these substances were most frequently explored.
    INTERPRETATION: The National ALS Registry is a multifaceted research platform, one component of which is funded research. This Registry-funded research fills an essential gap in the overall ALS scientific community as it is difficult to prevent and treat a disease without a deeper understanding of its causes.
    DOI:  https://doi.org/10.1002/acn3.51660
  47. Brain Spine. 2022 ;2 100889
      •Gender trends in authorship showed an increase in female authors from 1976 to 2020.•In 2020, Europe had the highest and Asia the lowest proportion of female authors.•The Netherlands had the highest proportion of women and Japan the lowest.
    DOI:  https://doi.org/10.1016/j.bas.2022.100889
  48. Plast Reconstr Surg Glob Open. 2022 Oct;10(10): e4611
      Plastic and reconstructive surgery (PRS) academic positions are more coveted each year. We aim to determine the requirement of fellowship training before PRS academic appointments.Methods: PRS faculty at U.S. academic institutions associated with the American Society of Plastic Surgeons were identified. Outcomes studied included integrated versus independent training, fellowships, gender, academic title, years on faculty, and publications before current hire.
    Results: Of the 1052 PRS faculty identified, 646 were included across 41 states and the District of Columbia. Seventy-four percent were identified as men (n = 477), and 26.2% (n = 169) identified as women. Academic faculty were significantly more likely to have completed fellowship before hire than not (p<0.0001). An integrated route of training was associated with higher odds of fellowship completion before appointment (OR = 2.19, 95% CI: 1.49-3.22). Odds of fellowship completion was significantly greater among faculty who graduated 5-10 years ago (OR = 2.55, 95% CI: 1.48-4.41) and within the last 5 years (OR = 1.93, 95% CI: 1.18-3.17). Professors were less likely to have completed fellowship training before appointment compared with assistant professors (OR = 0.51, 95% CI: 0.33-0.80). Regarding gender, number of prior publications, or completion of another degree, no significant difference was found between fellowship- and non-fellowship-trained faculty.
    Conclusions: Although more plastic surgeons enter the field through a shortened integrated residency, the increasing demand for further subspecialization may cause significant challenges for upcoming graduates pursuing an academic appointment. Undergoing additional training considerably impacts social and financial decision-making early in surgical careers for newly graduated residents.
    DOI:  https://doi.org/10.1097/GOX.0000000000004611
  49. Am J Surg. 2022 Oct 07. pii: S0002-9610(22)00637-7. [Epub ahead of print]
      INTRODUCTION: We evaluate National Institutes of Health (NIH) data to describe endocrine surgical research performed by surgeons in the United States.METHODS: An internal NIH database was queried for endocrine surgery-related grants awarded to surgeons in 2010, 2015, and 2020. The grants were then compared based on cost, grant type, research type, and endocrine topic.
    RESULTS: Eighteen grants ($6.4 M) focused on endocrine surgery-related research topics were identified in 2020, 17 ($7.3 M) in 2015, and 11 ($3.8 M) in 2010. In 2020, 14 grants were basic science and 4 were clinical outcomes, and pancreatic endocrine disease and thyroid disease each comprised 6 grants. R01 and R21 grants comprised 10 (55.6%) of the grants in 2020, compared to 10 (58.5%) in 2015 and 8 (72.7%) in 2010, while K08 and K23 grants increased to 4 (22.2%) in 2020 from 2 (11.8%) in 2015 and none in 2010.
    CONCLUSION: There were more K-awards focused on endocrine surgery-related research in 2020 compared to 2015 and 2010, suggesting the pipeline is growing.
    Keywords:  Endocrine surgery; NIH funding; Surgeon-scientist; Surgical research
    DOI:  https://doi.org/10.1016/j.amjsurg.2022.10.007
  50. Educ Inf Technol (Dordr). 2022 Oct 11. 1-26
      Around the world, the number of English speakers and the significance of the English language are constantly increasing. Among various technology-supported instructional styles, Mobile Learning (M-Learning) has been recognized as a promising approach to enhance students' competencies and skills in the English language. By examining previous literature, a number of reviews have been performed to investigate the role of M-learning in the English language. However, none of these studies has highlighted the trends, opportunities, and challenges identified in the most cited articles that focused solely on the English language. Therefore, to address these limitations, this study performed a review of the top 100 most cited articles, published between 2007 and 2020, indexed by the Web of Science, and addressing the English language only. The results revealed that most research in Mobile English Language Learning (M-ELL) followed an experimental design and employed a single mobile learning implementation. Additionally, the current study identified a number of research areas that require additional research attention. For example, further research is needed among students learning from home, more qualitative research is needed, and additional research is required to improve students' higher-order thinking skills. The outcomes of this study provide a reference to researchers and educators who intend to use mobile technologies in the area of language education, especially in the context of the English language.
    Keywords:  Applications in subject areas; M-ELL; Mobile learning; Pedagogical issues; Teaching/learning strategies
    DOI:  https://doi.org/10.1007/s10639-022-11352-6
  51. Rev Dev Econ. 2022 Sep 06.
      The COVID-19 outbreak has affected everyday lives worldwide. As governments started to implement confinement and business closure measures, the economic impact was felt by entire societies immediately. The urgency of such a theme has led researchers to study the phenomenon. Accordingly, the purpose of this research is to provide the state of the art on relevant dimensions and hot topics of research to understand the economic impacts of COVID-19. In this survey, we conduct a text mining analysis of 301 articles published during 2020 which analyzed such economic impacts. By defining a set of relevant dimensions grounded on existing literature, we were able to extract a set of coherent topics that aggregate the collected articles, characterized by the predominance of a few sets of dimensions. We found that the impact on "financial markets" was widely studied, especially in relation to Asia. Next, we found a more diverse range of themes analyzed in Europe, from "government measures" to "macroeconomic variables." We also discovered that America has not received the same degree of attention, and "institutions," "Africa," or "other pandemics" were studied less. We anticipate that future research will proliferate focusing on several themes, from environmental issues to the effectiveness of government measures.
    Keywords:  COVID‐19 pandemic; coronavirus outbreak; economic impact; literature analysis; text mining
    DOI:  https://doi.org/10.1111/rode.12931
  52. J Clin Transl Sci. 2022 ;6(1): e119
      This study proposes a new practical approach for tracking institutional changes in research teamwork and productivity using commonly available institutional electronic databases such as eCV and grant management systems. We tested several definitions of interdisciplinary collaborations based on number of collaborations and their fields of discipline. We demonstrated that the extent of interdisciplinary collaboration varies significantly by academic unit, faculty appointment and seniority. Interdisciplinary grants constitute 24% of all grants but the trend has significantly increased over the last five years. Departments with more interdisciplinary grants receive more research funding. More research is needed to improve efficiency of interdisciplinary collaborations.
    Keywords:  Interdisciplinary team science; program evaluation; research grants; scientific publications; temporal trends
    DOI:  https://doi.org/10.1017/cts.2022.455
  53. Laryngoscope. 2022 Oct 17.
      OBJECTIVE: To describe the changes in the quality of the Otolaryngology-Head and Neck Surgery (OTOHNS) literature over the last decade, and compare it to other surgical-based fields.METHODS: Based on impact factors, the top eight clinical U.S. OTOHNS journals were selected, and articles were analyzed from 2020 (Oto 2020) and compared to 2010 (Oto 2010). This was done similarly for Neurosurgery, Orthopedic, Ophthalmology, and General Surgery journals in 2020 (non-Oto). To limit bias and account for random variability, the first 10 research articles from each journal in each group were included. Data regarding the study type, level of evidence, use of confidence intervals, and funding source were collected.
    RESULTS: Based on an a priori power analysis, 160 articles were analyzed for Oto 2010 and Oto 2020. Compared to Oto 2020, Oto 2010 had more level 1 and 2 evidence (12 vs. 4; p = 0.032) and less reporting of confidence intervals (10 vs. 32; p < 0.001). Comparing the top 160 articles from 2020 from Non-Oto and OTOHNS (Oto), Non-Oto had more level 1 and 2 evidence (19 vs. 6; p = 0.0047), more randomized controlled trials (8 vs. 1; p = 0.016), and less reporting of confidence intervals (42 vs. 58; p = 0.009).
    CONCLUSION: High quality studies remain relatively scarce in the OTOHNS literature. Although reporting of confidence intervals has improved over the last decade, aggregate levels of evidence and extramurally funded studies lag behind other surgical-based fields. Better study design will provide stronger evidence basis, in hopes of improving clinical care.
    LEVEL OF EVIDENCE: Not applicable Laryngoscope, 2022.
    Keywords:  Otolaryngology; journals; levels of evidence; literature; publications; quality; surgical
    DOI:  https://doi.org/10.1002/lary.30446
  54. Humanit Soc Sci Commun. 2022 ;9(1): 372
      While rice studies are abundant, they usually focus on macro-level rice production and yield data, genetic diversity, cultivar varieties, and agrotechnological innovations. Moreover, many of these studies are either region-wide or concentrated on countries in the Global North. Collecting, synthesizing, and analyzing the different themes and topic areas in rice research since the beginning of the 21st century, especially in the Global South, remain unaddressed areas. This study contributes to filling these research lacunae by systematically reviewing 2243 rice-related articles cumulatively written by more than 6000 authors and published in over 900 scientific journals. Using the PRISMA 2020 guidelines, this study screened and retrieved articles published from 2001 to 2021 on the various topics and questions surrounding rice research in Indonesia and the Philippines-two rice-producing and -consuming, as well as emerging economies in Southeast Asia. Using a combination of bibliometrics and quantitative content analysis, this paper discusses the productive, relevant, and influential rice scholars; key institutions, including affiliations, countries, and funders; important articles and journals; and knowledge hotspots in these two countries. It also discusses the contributions of the social sciences, highlights key gaps, and provides a research agenda across six interdisciplinary areas for future studies. This paper mainly argues that an interdisciplinary and comparative inquiry of potentially novel topic areas and research questions could deepen and widen scholarly interests beyond conventional natural science-informed rice research in Indonesia and the Philippines. Finally, this paper serves other researchers in their review of other crops in broader global agriculture.
    Keywords:  Development studies; Environmental studies
    DOI:  https://doi.org/10.1057/s41599-022-01394-z
  55. Qual Quant. 2022 Oct 10. 1-31
      International Management is a vast and multidisciplinary research domain that is heavily influenced by several other disciplines, such as Economics, Organizational Theory and Strategic Management. Based on 28,973 research articles, this study aims to analyze the knowledge structure of the international management domain from 1920 to 2019. Using computational text-based topic modeling analysis, we trace the evolution of international management knowledge by examining the major academic topics/latent themes discussed in the field. The study also diachronically visualizes the variations in topic prevalence over time. Our methodology is akin to "inductive mapping" as it is neither biased by our position nor it is guided by assumptions related to the topics we expect to find. Results indicate the existence of a wide variety of important research foci in the domain of international management. These include, among others, strategic alliances formation, international entry modes, corporate social responsibility, cross-cultural consumer behavior, technological innovation and entrepreneurship. Results also show that some topics such as "financial risk and return on investment" and "corporate social responsibility" show a declining time trend, indicating that academic research focusing on such topics was more likely to be published early on and less so recently. On the other hand, other topics such as "Emerging (East) Asian nations" and "global mergers and acquisitions" show an increasing trend, indicating that more papers were published recently. Taken together, although our findings might reflect the breadth and depth of research in international management, they might also suggest that the bounds of this field are not well defined.
    Keywords:  International management; Machine learning; STM; Text mining; Topic modeling
    DOI:  https://doi.org/10.1007/s11135-022-01548-w