bims-evares Biomed News
on Evaluation of research
Issue of 2021‒08‒29
forty-six papers selected by
Thomas Krichel
Open Library Society

  1. Ann Transl Med. 2021 Jul;9(13): 1065
      Background: Wnt signaling pathway plays a vital role in the regulation of development. An increasing number of articles about Wnt pathway components have been published. By analyzing these studies' characteristics and qualities, we aim to reveal the current research focus and emerging trends in Wnt signaling.Methods: The databases of Web of Science Core Collection, BIOSIS Citation Index, MEDLINE, etc. were utilized to identify articles on May 23rd, 2020. Wnt signaling pathway-related articles were identified, the 100 most cited articles and articles in the last decade were selected and calculated for citations without self-citation. The subsequent analysis included citation density (citations/article age), time-related flux, authorship, institution, journal, geographic distribution, and theme.
    Results: These articles were published mainly from 2000 to 2009 (62%). Citations per article ranged from 599 to 3,780 with a median number of 880 times. Most studies (66%) came from the United States. Nusse Roel and Clevers Hans (15 and 13 papers) have contributed significantly to the field. The most highlighted study themes were cancer (15%), embryo development (14%), and cytoplasm signal transduction (11%). From 2011 to 2020, interest in emerging subtopics, including osteogenesis, immune, apoptosis, autophagy, microRNA, and cancer stem cell, are rising.
    Conclusions: Cancer, embryo development, stem cell, and signal transduction process still play a major role in the field. With multiple emerging subtopics and investigation on an integrated view of the Wnt signal network, the association of Wnt with diseases was further revealed.
    Keywords:  Bibliometric analysis; Wnt; cancer; cell signaling; embryo development; top-100 articles; β-catenin
  2. Environ Sci Pollut Res Int. 2021 Aug 24.
      Mendelian randomization (MR) is attracting considerable critical attention. This paper aimed to explore the characteristics of the publications of MR, to reach an insight in this field and prospect the future trend. A bibliometric analysis was performed to identify published MR-related research. The articles were selected from the Web of Science Core Collection database. Excel 2019, VOSviewer 1.6.9, and CiteSpace 5.7.R3 were used to analyze the information. A total of 1783 papers of MR were identified, and the first included literature appeared in 2003. A total of 2829 institutions from 72 countries participated in the relevant research, while the UK contributed to 852 articles and were in a leading position. The most productive institution was the University of Bristol, and Smith GD who has posted the most articles (n=202) was also from there. The Int J Epidemiol (100 publications, 6861 citations) was the most prolific and high citation journal. Related topics of frontiers will still focus on coronary heart disease, diabetes, cancer, psychiatric disorder, body mass index, and lifestyle factors. We summarized the publication information of MR-related literature from 2003 to 2020, including country and institution of origin, authors, and publication journal. We analyzed former research hotspots in the field of MR and predicted future areas of interest. Exposures and outcomes detected in this paper will be the hotspots and frontiers of research in the next few years.
    Keywords:  Bibliometric analysis; Citation analysis; Mendelian randomization analysis; Visualization
  3. J Vasc Surg. 2021 Aug 24. pii: S0741-5214(21)01962-5. [Epub ahead of print]
      OBJECTIVES: Prior research in vascular surgery has identified significant gender disparities in leadership positions, but few data exist regarding gender disparities in vascular publications. This study aims to evaluate authorship trends by gender in the three highest impact factor vascular surgery journals.METHODS: In this bibliometric analysis, PubMed was searched for articles published in the European Journal of Vascular and Endovascular Surgery, the Journal of Vascular Surgery, and Annals of Vascular Surgery from 2015-2019. The web-based application Genderize used predictive algorithms to classify names of first and last authors as male or female. Statistical analyses regarding trends in authorship were performed using Stata16.
    RESULTS: A total of 6,457 articles were analyzed, with first author gender predicted with >90% confidence in 83% (4889/5796) and last author gender in 88% (5078/5796). Overall, 25% (1223/4889) of articles had women first authors, and 10% (501/5078) had women last authors. From 2015-2019, there was a slight increase in the proportion of articles written by women first authors (p=0.001), but no increase in the proportion of articles written by women last authors (p=0.204). The proportion of articles written by women last authors was lower than the proportion of active women vascular surgeons in 2015 (8% articles vs 11% surgeons, p=0.015), 2017 (9% of articles vs 13% surgeons, p<0.001), and 2019 (11% of articles vs 15% practicing surgeons, p<0.001). The average number of last-author publications was higher for men (2.35±3.76) than for women (1.62±1.88, p=0.001). The proportion of unique authors who were women was less than the proportion of active women vascular surgeons in 2017 (10% unique authors vs 13% surgeons, p=0.047), but not in 2015 (9% unique authors vs 11% surgeons, p=0.192) or 2019 (13% unique authors vs 15% surgeons, p=0.345). Notably, a woman last author was associated with 1.45 higher odds of having a woman first author (95%CI 1.17-1.79, p=0.001).
    CONCLUSIONS: Over the last five years, there has been no significant increase in women last authors among top-tier journals in vascular surgery. Women remain under-represented as last authors in terms of proportion of published articles, but not in terms of proportion of unique authors. Nevertheless, women last authors are more likely to publish with women first authors, indicating the importance of women-led mentorship in achieving publication gender equity. Support for women surgeons through grants and promotions is essential not only for advancing last authorship gender equity, but for advancing junior faculty and trainee academic careers.
    Keywords:  academic advancement; academic surgery; authorship; gender equity; publication trends; vascular surgery; women in surgery
  4. J Pediatr Urol. 2021 Aug 11. pii: S1477-5131(21)00375-2. [Epub ahead of print]
      INTRODUCTION: In the last 120 years, the field of pediatric urology has seen an exponential growth. In this time, there has not been a comprehensive review of top cited articles within the field.OBJECTIVES: We aim to identify and categorize the top 100 most cited peer-reviewed articles in pediatric urology using citation analysis.
    STUDY DESIGN: We searched for articles in the Web of Science™ Core Collection between 1900 and 2020 using terms specific to pediatric urology. We identified relevant pediatric urology articles and selected the top 100 most cited articles. We analysed trends over time for topics and categories and we evaluated the relatedness of these articles using citation analysis software.
    RESULTS: The top 100 most cited articles in pediatric urology were published between 1958 and 2016 in 26 countries, across 181 institutions, and in 46 journals. The median number of citations per article was 268 (IQR 225.75-394.25). Clinical manuscripts were the most common among the top 100 cited articles (n = 64) and the most common topic was genital conditions (e.g., penile, inguinal, or testis but not including hypospadias) (n = 19; 16.5%; total citations = 6591). When using bibliometric software to analyse relatedness among the top 100 articles based on citation of one another, we identified 11 clusters of 3 or more articles which corresponded to topics like those we defined a priori (Summary Figure). We found that a greater proportion of articles describing surgical techniques were published prior to 1987 (n = 6, 38%) as compared to after 1987 (n = 11, 13%), while the proportion of basic science articles has increased.
    DISCUSSION: This is the first study to analyse the most cited articles in pediatric urology. There was a lower median citation per article and fewer prospective studies in this list compared to other urologic sub-specialties. Similar to other clinical specialties, the focus has moved from describing and comparing operative techniques to exploring mechanisms of disease. This study is limited by using a single parameter (citation rate) and a single citation database.
    CONCLUSION: The list of top 100 most cited articles in pediatric urology is an important resource for clinicians and trainees to understand the body of knowledge and trajectory of this field. It charts the evolution of the field and highlights areas of potential investigation. This objective approach to literature review can facilitate future research and education efforts.
    Keywords:  Bibliometric analysis; Impact factor; Journal citation reports; Pediatric urology
  5. Environ Sci Pollut Res Int. 2021 Aug 23.
      The application of low-carbon alcohols (LCA fuels) in internal combustion engines has become one of the most important topics in road transport decarbonization. This paper aims to identify the trends and characteristics of LCA combustion research for the period 2000-2021 through bibliometric analysis. Citation analysis is used to evaluate the influence of most productive journals, countries/regions, authors, institutions, and relevant literature, while collaborative network between various authors, countries/regions, institutions, and the co-occurrences among different keywords are discussed. A dataset of 2250 publications was extracted from the Web of Science Core database and analyzed with CiteSpace and Biblioshiny. The extracted documents involve 429 journals of publications by 4782 authors from 1434 institutions across 83 countries/regions. The results reveal that the research output in this field has undergone three main stages of development, i.e., initial development (2000-2007), slow development (2008-2015), and rapid development (2016-2021). Currently, the research field is growing at an annual growth rate of 9.24%, with most of the contributions by authors and institutions originating from China. The analysis from relevant keywords and literature suggests that the core of this research field centers on the combustion, performance, and emission characteristics of LCA-fueled engines. The current study helps keep the scientific community informed of the latest paradigms in the LCA combustion research field.
    Keywords:  Bibliometric analysis; Ethanol; Internal combustion engine; Low-carbon alcohol (LCA); Methanol
  6. Ann Transl Med. 2021 Jul;9(14): 1122
      Background: Periodontal disease is a leading cause of tooth loss, and microRNA (miRNA) has been shown to regulate various biological processes. This study aimed to quantitatively analyze the literature related to miRNA in periodontology and dental implantology and summarize the research hotspots and trends in this field.Methods: Literature records from 1985 to 2020 were obtained from the Web of Science Core Collection database. After manual selection, the data was used for cooperative network analysis, keyword co-occurrence analysis, and reference co-citation analysis and visualized by CiteSpace.
    Results: A total of 287 papers were analyzed between 2007 and 2020, and more than 95% of them were published in the past decade. The largest number of publications were from China, followed by the USA and Japan. The direct cooperation among the productive institutions was not close. At present, most of the research belongs to the discipline of dentistry, oral surgery, cell biology, and molecular biology. Literature clusters generated by reference co-citation analysis and keyword co-occurrence network showed that previous studies mainly focused on four hotspots: periodontal ligament stem cells (PDLSCs), the pathological process of periodontitis, osteogenic differentiation/bone regeneration, and the competing endogenous RNA (ceRNA) network.
    Conclusions: The therapeutic potential of miRNA in promoting bone formation and how the ceRNA network contributes to miRNA regulation at a deeper level have become the two main research trends of this field.
    Keywords:  CiteSpace; MicroRNA (miRNA); bibliometric analysis; dental implants; periodontics
  7. Healthcare (Basel). 2021 Aug 06. pii: 1008. [Epub ahead of print]9(8):
      (1) Background: A bibliometric review of psycho-oncology research is overdue. (2) Methods: The 100 most-cited journal articles were compiled and ranked according to Scopus. (3) Results: The total citation count for the results ranged from 488-8509 (Mean = 940.27; SD = 1015.69). A significant correlation was found between years since publication and number of citations (p = 0.039). The majority of research originated from the United States (66%). The vast majority of research publications were original articles (80%). Observational research study designs represented the majority of studies (37%). Mixed cancer population research studies represented the largest cancer research population (36%). Positive psychology topics represented the most prolific proportion of studies (30%). Findings were reported in line with PRISMA-ScR guidelines. (4) Conclusions: This analysis offers a comprehensive account of seminal journal articles in psycho-oncology, identifying landmark contributions and areas for future research developments within the field, namely highlighting a need for more RCT studies. This analysis serves as an educational tool for interdisciplinary researchers and clinicians to support compassionate cancer care.
    Keywords:  bibliometrics; cancer; multidisciplinary; oncology; psycho-oncology; review
  8. Int J Environ Res Public Health. 2021 Aug 23. pii: 8859. [Epub ahead of print]18(16):
      Petroleum contaminated soils have become a great concern worldwide. Bioremediation has been widely recognized as one of the most promising technologies and has played an important role in solving the issues of petroleum contaminated soils. In this study, a bibliometric analysis using VOSviewer based on Web of Science data was conducted to provide an overview on the field of bioremediation of petroleum contaminated soils. A total of 7575 articles were analyzed on various aspects of the publication characteristics, such as publication output, countries, institutions, journals, highly cited papers, and keywords. An evaluating indicator, h-index, was applied to characterize the publications. The pace of publishing in this field increased steadily over last 20 years. China accounted for the most publications (1476), followed by the United States (1032). The United States had the highest h-index (86) and also played a central role in the collaboration network among the most productive countries. The Chinese Academy of Sciences was the institution with the largest number of papers (347) and cooperative relations (52). Chemosphere was the most productive journal (360). Our findings indicate that the influence of developing countries has increased over the years, and researchers tend to publish articles in high-quality journals. At present, mainstream research is centered on biostimulation, bioaugmentation, and biosurfactant application. Combined pollution of petroleum hydrocarbons and heavy metals, microbial diversity monitoring, biosurfactant application, and biological combined remediation technology are considered future research hotspots.
    Keywords:  VOSviewer; bibliometric analysis; bioremediation; petroleum contamination; soil
  9. Dis Markers. 2021 ;2021 8870353
      Background: Bladder cancer is amongst the top 10 most common neoplasms worldwide. It is responsible for over 150,000 deaths per annum. It is of great importance to study its clinical diagnosis and management. As a literature synthesis technique, bibliometrics analysis helps us to take our knowledge of bladder cancer diagnosis research, topics, and trends a step further. It is critical to elucidate the literature landscape and its pertinent impact on this field, in order to have a better understanding and improved management of bladder cancer.Materials and Methods: Search terms related to bladder cancer diagnosis were used to retrieval publications which met the predefined criteria in the Scopus database developed by Elsevier. Included articles were further evaluated by year of publication, country, language, institution, article type, source journal, coauthorship networks, and text mining of titles. The R software, as well as the tm, ggplot2 packages, and the VOSviewer (version 1.6.15) were used as software tools.
    Results: A comprehensive literature search in the Scopus database returned a total of 824 publication items. Among them, 601 (72.94%) were published as journal articles, and 117 (14.20%) were published as reviews. The number of annual publications in this field has been increasing in recent years. English represents the language used in the majority of the articles (634, 77.13%). The highest number of citations received for a single article is as high as 628 times. We also clustered and visualized a network of 701 authors with no less than 3 publications. The term cloud and hierarchical clustering dendrogram which revealed with text mining were used to discover the hot research topics in this field. We also statistically analyzed evolution of the major journal impact indices, including Impact Factor, EigenFactor Score, and CiteScore of 11 journals with a period of 9 years.
    Conclusion: Through bibliometrics analysis, we found hot topics and related research focuses and trends in bladder cancer diagnosis. This bibliometrics analysis has identified influential articles in the field and provides a useful guide to researchers as to what type of article constitutes a highly citable publication in this subject. In addition, a coauthorship network helps researchers find out which team may be a potential partner and where their studies focus on.
  10. Orthop Surg. 2021 Aug 22.
      OBJECTIVE: To highlight the characteristics of the most highly cited articles and propose the research interests over the past decades in the field of femoroacetabular impingement (FAI) and labral tear.METHODS: The ISI Web of Science database (Clarivate Analytics, New York, the United States) was utilized for the identification of articles on 15 December 2020. FAI and labral tear-related articles (1138 articles) were retrieved, of which the 100 most-cited articles (top 100) were identified. Subsequent analysis included citation density (citations/article age), authorship, institution, journal, geographic distribution, level of evidence, and theme.
    RESULTS: The number of citations per article ranged from 66 to 1189 with a mean of 163.31. The majority of articles were published in the United States (all articles/top 100 = 655/57) and Switzerland (85/22). University of Bern (n = 10) was the most prolific institution. The journal with the most of articles was Arthroscopy: The Journal of Arthroscopic and Related Surgery. The most prolific coauthor (all articles) or first authors (top 100) was Domb (n = 109) and Philippon (n = 6), respectively. The evidence with the most articles is level IV (n = 41). The top three most popular topics of research article were outcomes of surgery (n = 23), imaging diagnosis (n = 18), and comparison of surgery (n = 8). The top four most prevalent themes of review were labral tears (n = 3), FAI (n = 3), comparison of surgery imaging diagnosis, and outcomes of surgery (both n = 2). Six keywords with the newest average publication year, including FAI syndrome (average publication year = 2019.50), patient-reported outcomes (2019.43), femoroplasty (2018.60), clinical outcomes (2018.17), borderline dysplasia (2018.00), and capsule (2018.00). Five keywords with the highest average citations, including outcome (average citations = 88.50), alpha angle (58.00), complications (55.86), revision hip arthroscopy (49.00), and systematic review (46.14).
    CONCLUSIONS: Outcomes research is the most popular research interest and patient-reported outcome instruments might be further and widely used in the emerging articles in the near future. The field of FAI and labral tear has shown an obvious trend of development and is steadily evolving. It could be predicted that there will be an increasing number of publications in the following years, with the United States and Switzerland maintaining leadership in this field.
    Keywords:  Bibliometric analysis; FAI; Femoroacetabular impingement; Labral tear; Research interests
  11. Ear Nose Throat J. 2021 Aug 25. 1455613211042113
      OBJECTIVE: Determine whether social media platforms can influence article impact as measured by citations.METHODS: Cross-sectional study that analyzed articles published in the top 10 otolaryngology journals by Eigenfactor score in January 2015. Total accumulated Twitter mentions and citations were recorded in 2021. The main outcomes examined the difference in citations, tweets, article types, and author counts accumulated over a 5-year period for all articles that were either tweeted or nontweeted.
    RESULTS: A total of 3094 articles were included for analysis. The average article was cited 11.2 ± 13.2 times and tweeted 2.10 ± 4.0 times. Sixty-four percent of the articles had at least one tweet. Over the study period, there was a statistically significant difference in mean number of citations between tweeted articles (12.1 ± 15.0) versus nontweeted articles (9.6 ± 10.5) citations, representing a 26% difference (P < .001). Review articles had the highest mean citations (19.4 ± 23.4) while editorials had the lowest mean citations (2.8 ± 6.9). Tweets peaked in the year of publication, but citations continued to rise in the subsequent years. Tweeted articles' peak citation rate change was +1.27 mean citations per year, compared to +0.99 mean citations per year in nontweeted articles. The mean author count in tweeted articles (5.40 ± 3.1) was not significantly different than the mean author count in nontweeted articles (5.19 ± 2.65, P = .0794).
    CONCLUSION: These data suggest a moderate correlation between tweets and article citations, but a clear difference in the number of citations in articles tweeted versus those with no tweets. Thus, dissemination of knowledge may be impacted by social medial platforms such as Twitter.
    Keywords:  Twitter; altmetrics; bibliometrics; journal impact factor; scientometrics
  12. J Pain Res. 2021 ;14 2513-2528
      Background: Low back pain (LBP) is a highly prevalent musculoskeletal disorder that contributes to the greatest degree of disability worldwide. It has become a very serious public health problem that has attracted considerable research interest. The number of publications associated with LBP and physical activity (PA) is gradually increasing. Nevertheless, few studies have utilised visualisation in analysing the general aspects of this field. Therefore, we aimed to provide a systematic overview of global scientific research related to low back pain and physical activity from 2000 to 2020. It has significant benefits in terms of providing researchers with the status and trends of research on low back pain and physical activity.Methods: Publications on Science Citation Index-Expanded of Web of Science from 2000 to 2020 were searched, and publications relevant to LBP and PA were analysed using Citespace and SPSS. Analyses mainly included cooperation amongst authors, countries and institutions; co-occurrence analysis of keywords; and co-citation analysis of references, revealing productive researchers and contributing institutions tracking the status and trend of research fields.
    Results: Results of linear regression analysis showed that the number of publications on LBP and PA studies increased significantly (p<0.001). The subject categories predominantly focused on orthopaedics (2579, 26.54%), rehabilitation (2544, 26.18%) and sport sciences (2015, 25.44%). The United States had the highest number of published papers (2700, 27.789%) and citations (86, 958). In terms of the number of publications, amongst the top 20 journals, Spine contributed the most, whilst the British Journal of Sports Medicine had the highest impact factor (IF2019, 12.022). The University of Sydney had the highest number of publications (330 publications). Maher published the most papers (123 papers) and had the highest H-index (41). Several citation articles and keywords (such as aerobic, obesity and fear-avoidance beliefs) can be used to provide frontier clues for research on LBP and PA.
    Conclusion: The results of our study may provide information, such as research trends and frontiers of research and collaborating partners, institutions and countries, on LBP and PA.
    Keywords:  Web of Science; low back pain; physical activity; research trends
  13. Arthrosc Sports Med Rehabil. 2021 Aug;3(4): e1243-e1253
      Purpose: To objectively identify the 50 most influential studies in knee arthroscopy and provide an analysis of their key characteristics.Methods: The Clarivate Analytics Web of Knowledge database was used to gather data and metrics of knee arthroscopy research. The search list was sorted by the number of citations, and articles were included or excluded based on relevance to knee arthroscopy. The information extracted for each article included author name, publication year, country of origin, journal name, article type, and the level of evidence.
    Results: For these 50 studies, the total number of citations was calculated to be 12,168, with an average of 243.4 citations per paper. The most-cited article was cited 1,220 times. The 50 studies included in this analysis were published between 1972 and 2013. All 50 articles were published in English and came from 10 different orthopaedic journals. The United States was responsible for the majority of articles (n = 26); however, many other countries were represented. The most prevalent study designs were case series (n = 20).
    Conclusions: The 50 most influential articles in knee arthroscopy were cited a total of 12,168 times. The study designs most commonly used were case series and cohort studies. This article serves as a reference to direct orthopaedic practitioners to the 50 most influential studies in knee arthroscopy. We hope that these 50 studies and the analysis we provide help health care professionals efficiently assess consensus, trends, and needs within the field.
    Clinical Relevance: This analysis of the 50 most influential studies in knee arthroscopy will provide medical students, residents, fellows, and attending physicians with a comprehensive inventory and citation analysis of the most impactful academic contributions to one of the most important fields within orthopaedic surgery.
  14. Ann Transl Med. 2021 Jul;9(13): 1090
      Background: Spine-related research continues to evolve rapidly and in the paradigm of increasing data, evidence-based practice becomes imperative. Citation-based rankings are thus critical in allowing clinicians to quickly ascertain the importance and value of a study. The purpose of this article is to report on the 10 most cited articles in the field of spine surgery over the last 10 years to provide an insight into the direction of research and clinical endeavors.Methods: Google Scholar was searched (1st April 2021) using an algorithm that sorts all cited spine surgery publications based on the number of citations per year. The top 10 most cited articles were identified. Information including journal, publication title, published year, subspecialty, and purpose of the study were compiled.
    Results: The top 10 publications ranged from 471 to 66 citations, with yearly citations ranging from 67 to 14. Eight articles directly related to lumbar fusion, 2 related to 3D Printing in spinal surgery, and one article on robotic surgery. There were 4 retrospective studies, 1 randomized controlled trial (RCT), and 2 systematic reviews. 3 of the papers related to decision making in surgery, 4 on outcomes of surgery, and 3 on innovations in surgery. The journal that appeared most frequently in the top 10 list was the Journal of Spine Surgery.
    Discussion: Novel surgical approaches or management strategies are almost always a manifestation of advancements in clinical and basic science research. Algorithm-based identification of highly cited articles provides an effective and prompt avenue for evidence-based medicine. Our ranking found a predominance of publications related to lumbar spinal fusion. Several articles in the top 10 provide an in-depth discussion on novel surgical techniques and technologies that define the current epoch of innovations in spine surgery.
    Keywords:  Spine surgery; citation analysis; citation ranking; lumbar fusion
  15. J Appl Clin Med Phys. 2021 Aug 28.
      PURPOSE: Medical images are important in diagnosing disease and treatment planning. Computer algorithms that describe anatomical structures that highlight regions of interest and remove unnecessary information are collectively known as medical image segmentation algorithms. The quality of these algorithms will directly affect the performance of the following processing steps. There are many studies about the algorithms of medical image segmentation and their applications, but none involved a bibliometric of medical image segmentation.METHODS: This bibliometric work investigated the academic publication trends in medical image segmentation technology. These data were collected from the Web of Science (WoS) Core Collection and the Scopus. In the quantitative analysis stage, important visual maps were produced to show publication trends from five different perspectives including annual publications, countries, top authors, publication sources, and keywords. In the qualitative analysis stage, the frequently used methods and research trends in the medical image segmentation field were analyzed from 49 publications with the top annual citation rates.
    RESULTS: The analysis results showed that the number of publications had increased rapidly by year. The top related countries include the Chinese mainland, the United States, and India. Most of these publications were conference papers, besides there are also some top journals. The research hotspot in this field was deep learning-based medical image segmentation algorithms based on keyword analysis. These publications were divided into three categories: reviews, segmentation algorithm publications, and other relevant publications. Among these three categories, segmentation algorithm publications occupied the vast majority, and deep learning neural network-based algorithm was the research hotspots and frontiers.
    CONCLUSIONS: Through this bibliometric research work, the research hotspot in the medical image segmentation field is uncovered and can point to future research in the field. It can be expected that more researchers will focus their work on deep learning neural network-based medical image segmentation.
    Keywords:  bibliometric; image segmentation; medical image; publication trends; research productivity
  16. Asian Pac J Cancer Prev. 2021 Aug 01. pii: 89734. [Epub ahead of print]22(8): 2385-2389
      BACKGROUND: Breast cancer has a rich history of research over the past 75 years. Many studies have had disruptive influences on the field itself. Our study employs a new, validated measurement to determine the most disruptive publications within the field of breast cancer.MATERIALS AND METHODS: PubMed® database was queried for articles between 1954-2014 related to breast cancer with in 21 different journals deemed important to the field. Articles were then scored for disruption and citation count. The top 100 most disruptive and cited publications were compiled and analyzed.
    RESULTS: Disruption score was a distinct measurement from citation count and had low level of correlation. Disruptive publications tended to skew older with the median year of publication in 1977. The score identified a variety of study designs and publication types within multiple journals.
    CONCLUSIONS: Measurement of the disruptive quality of a publication is a new way to describe academic impact of a publication and is distinct from citation count. Used in conjunction with citation count in may give a more descriptive bibliometric assessment of the literature. Further exploration within the field of oncology is warranted.<br />.
    Keywords:  Bibliometrics; Disruption; breast cancer
  17. Front Genet. 2021 ;12 610728
      Background: Approximately 50% of cataracts are associated with genetic factors. Genetic etiology and molecular mechanisms based on gene research increase the understanding of cataracts and provide direction for diagnosis and intervention. In the present study, SCIE papers related to the modeling of cataract gene research from 2010-2019 were evaluated and qualitative and quantitative analyses with modeling performed. Methods: The SCIE database was searched on July 6, 2021 for cataract gene publications and relevant papers published since 2010 were considered for review. Subsequently, 1,904 SCIE papers associated with cataract genes from 2010-2019 were analyzed using a bibliometric method. The publication, country, institution, journal, references, knowledgebase, keywords, and research hotspots of the papers were analyzed using an online analysis platform of literature metrology, bibliographic item co-occurrence matrix builder (BICOMB), CiteSpace V, and VOS viewer analysis tool. Results: 78 countries published the related articles, and the United States ranks of America had the most publications. Two thousand seven hundred and eighty three institutions contributed to the related publications. Fudan University had the most publications. The reference clusters of SCI papers were clustered into six categories, namely, causing congenital cataract-microcornea syndrome, functional snp, cataractous lenses, a1 mutation, foxe3 mutation, cell adhesion gene pvrl3, nid1 gene. The key words representing the research frontiers were cerebrotendinous xanthomatosis (2017-2019), oxidative stress (2017-2019). Conclusion: This study provided a systematic, objective and comprehensive analysis of the literature related to gene research of cataract. Moreover, this study demonstrated the current hotspots and the future trends in the field of gene research of cataract. This review will help ophthalmologist to discern the dynamic evolution of cataract gene research, as well as highlight areas for future research.
    Keywords:  VOSviewer; bibliometric; cataract; citespace; data visualization; gene
  18. J Trop Med. 2021 ;2021 4267230
      Purpose: The current study quantitatively assessed research trends in tropical medicine in China via a bibliometric method, which used the Web of Science database to analyse the research-based literature related to tropical medicine published from 2010 to 2019.Methods: Articles were analysed according to the output and research performance of institutes and countries that collaborated with China. Distribution of keywords was applied to evaluate research trends.
    Results: Our findings showed that 3372 articles in the field of tropical medicine have been indexed under the Web of Science database during the past 10 years, indicating that studies pertaining to tropical medicine have been growing from 2010 to 2019. The Chinese Center for Disease Control and Prevention (China CDC) system, which published 549 articles on tropical medicine, may be considered as the flagship of tropical medicine in China. The United States ranked first in internationally collaborative articles with China. Furthermore, Parasite & Vectors, which published 707 papers, emerged as the top journal according to the number of publications.
    Conclusions: This study highlights the key institutes and topics pertaining to tropical medicine research in China. Although there has been rapid progress in research on tropical medicine in China, some gaps still remain.
  19. Front Pharmacol. 2021 ;12 650141
      Background: An increasing number of studies have shown that natural products have anti-tumor effects, and it has become a hotspot in cancer research. However, few bibliometric analyses have been examined in this field systematically. The current study aimed to explore the status and provide the developing trends in the natural products on cancer research. Methods: Publications on natural products in cancer research were extracted from the Web of Science core collection database. CiteSpace (5.6.R3) software and GraphPad prism 6 were used to analyze and plot the references. Results: On February 1, 2021, 34,611 records of natural products in cancer research published from 2008 to 2020 were collected. The United States was the driving force, with a strong academic reputation in this area. The top-contributing institution was the Chinese Academy of Sciences. Most publications were published in Molecules. Efferth Thomas was the most prolific author, while Newman DJ was the most cited and frequently co-cited author. Flavonoid, curcumin, and polyphenol were the most widely studied natural products. Oleanolic acid and rosmarinic acid have gradually become research hotspots recently. Breast cancer, prostate cancer, and colorectal cancer were the most common types of cancer in this field. "Natural killer cell" was the leading research hotspot. The keywords of "leaf extract," "molecular docking" and "gold nanoparticle" appeared most recently as research frontiers. Conclusion: Our results provided a general overview of the major research directions of natural products research in cancer. The mechanisms of natural products, especially those related to molecular docking, gold nanoparticle, gut microbiota, and immune checkpoints may soon become hotspots and should be closely monitored.
    Keywords:  bibliometric; cancer; citation analysis; gut microbiota; immune checkpoint; molecular docking; natural product
  20. Membranes (Basel). 2021 Aug 07. pii: 600. [Epub ahead of print]11(8):
      Hollow fiber membrane (HFM) technology has received significant attention due to its broad range separation and purification applications in the industry. In the current study, we applied bibliometric analysis to evaluate the global research trends on key applications of HFMs by evaluating the global publication outputs. Results obtained from 5626 published articles (1970-2020) from the Scopus database were further manipulated using VOSviewer software through cartography analysis. The study emphasizes the performance of most influential annual publications covering mainstream journals, leading countries, institutions, leading authors and author's keywords, as well as future research trends. The study found that 62% of the global HFM publications were contributed by China, USA, Singapore, Japan and Malaysia, followed by 77 other countries. This study will stimulate the researchers by showing the future-minded research directions when they select new research areas, particularly in those related to water treatment, biomedical and gas separation applications of HFM.
    Keywords:  VOSviewer; bibliometric analysis; future trends; gas separation; hollow fiber membrane; water treatment
  21. Diabetes Metab Syndr. 2021 Aug 17. pii: S1871-4021(21)00270-8. [Epub ahead of print]15(5): 102250
      AIMS: Due to the importance of omics approaches in diabetes diagnosis, we were assumed to study the scientific activities on omics and type 2 diabetes worldwide.METHOD: Bibliometric approach was utilized to evaluate the documents on proteomics, lipidomics, and metabolomics in patients with type 2 diabetes in the Scopus database from the beginning to 2020. The articles were screened by two reviewers and the number of publications and citations on omics and type 2 diabetes, top-ranked journals, top-cited articles, country co-contributions, co-authorships, author keywords, and terms were analyzed.
    RESULTS: The scientific publications in this field consisted of 551 original articles, of which the USA shares the most percent, followed by China and Germany. The frequent keywords showed that the following hotspots were of interest: "Metabolomics, proteomics, and lipidomics as biomarkers for diabetes", "Omics and diabetic nephropathy", "The application of omics in obesity, insulin resistance, and type 2 diabetes".
    CONCLUSION: This study showed an increasing trend in applying omics in type 2 diabetes researches and determined the leading producers in this field. Besides, the research hotspots and the main subjects of documents were provided for future research and policy decision-making.
    Keywords:  Bibliometric; Diabetes; Lipidomics; Metabolomics; Omics; Proteomics
  22. Healthcare (Basel). 2021 Jul 30. pii: 969. [Epub ahead of print]9(8):
      This paper systematically reviews and synthesizes the relevant literature on sedentary time research. A bibliometric analysis was conducted to evaluate the publications from 2010 to 2020 in the Web of Science (WoS) core collection database. Derwent Data Analyzer software was used for the cleaning, mining, and visualization of the data. Historical trends of the topics, main contributors, leading countries, leading institutions, leading research areas, and journals were explored. A total of 3020 publications were studied. The United States, the United Kingdom, and Australia are the three most productive countries. The Australian institution Baker Heart and Diabetes Institute led the list of productive institutions, and Ekelund U published the most papers. Sedentary time raised the concerns of scholars from 106 research areas, and public health was the dominant field. Physical activity, accelerometer, children, and obesity were the most frequently used keywords. The findings suggest that sedentary time is rapidly emerging as a global issue that has detrimental effects on public health. The hotspots shifted in the past 10 years, and COVID-19 was the most popular topic of sedentary time research.
    Keywords:  COVID-19; bibliometric; children; physical activity; sedentary time
  23. Global Health. 2021 Aug 24. 17(1): 94
      BACKGROUND: Irrational use of antimicrobials is highly prevalent. It is a major driving factor for antimicrobial resistance (AMR). Research on irrational antimicrobial use is important for developing policies and regulations to combat and contain AMR. The present study aims to provide an overview of research publications on the irrational use of antimicrobials at the national and global levels.METHODS: Publications on irrational use of antimicrobials were extracted from Scopus using a wide range of relevant keywords for the study period from 1980 to 2020.
    RESULTS: In total, 656 publications on irrational use of antimicrobials were found. The bulk of publications in this field were about irrational use in humans. A limited number of publications were found on the irrational use of antimicrobials in the context of veterinary and environment. The number of publications, contributing countries, and the mean number of authors per article increased with time, most notably in the last decade. Authors from 105 different countries participated in publishing the retrieved articles with 22 (21.0%) participated in 10 or more publications. The United States led with 140 (21.6%) articles followed distantly by China (n = 49, 7.5%), India (n = 45, 6.9%), and the United Kingdom (n = 45, 6.9%). Countries in the South-East Asian region (n = 69, 10.5%) and the African region (n = 42, 6.4%) made the least contribution. The list of most frequent author keywords included "antimicrobial stewardship" and "community pharmacies". The research themes focused on the hospital-based rational use of antimicrobials and the self-medication practices with antimicrobials in the community. In total, 420 different journals participated in publishing the retrieved documents. The Plos One journal (17, 2.6%) ranked first. The retrieved articles received an average of 15.6 citations per article and an h-index of 52. The most frequent antimicrobials encountered in the retrieved literature were penicillin, cephalosporin, and fluoroquinolones while the most frequently encountered pathogens were S. aureus and P. aeruginosa.
    CONCLUSION: Research on the irrational use of antimicrobials is needed from all countries and regions to implement appropriate policies to contain the AMR. Research on irrational use of antimicrobials in the context of veterinary is needed.
    Keywords:  Antimicrobial resistance; Antimicrobials; Irrational use; Misuse; Research
  24. Med J (Ft Sam Houst Tex). 2021 Jul-Sep;(PB 8-21-07/08/09): 57-62
      BACKGROUND: Emergency medicine is recognized as a critical wartime specialty within the US military. Military emergency medicine contributes to medical literature in unique ways not seen with our civilian counterparts. The impact of this contribution, especially regarding innovations in military medicine, has not been previously examined. This study evaluates the numbers of citations for emergency medicine manuscripts published by members of the US military.METHODS: Utilizing the Scopus database, we identified published manuscripts from 2000 to 2020 with an emergency medicine author affiliated with a US military treatment facility. We sorted manuscripts on the number of citations in Scopus and categorized each paper as to whether it addressed military unique topics.
    RESULTS: We identified 1,718 manuscripts through Scopus, and based on a 10-citation minimum, we further analyzed 508 manuscripts. After verification of military affiliation, we included 421 manuscripts. The mean number of citations per manuscript was 31.7 ± 40.5; the Mean Cite Score was 4.75 ± 6.17 with a Field Weighted Citation Index (FWCI) of 2.96 ± 6.25. Citation count of publications has been steadily increasing in recent years with significantly more citations for military relevant publications when compared to non-military relevant publications.
    CONCLUSIONS: These findings highlight the importance of military emergency medicine scholarly activity which has a history of contributions that address specific medical needs of the warfighter and advance the specialty. Military emergency medicine papers have seen rising numbers of citations in the medical literature, particularly those related to military relevant topics emphasizing combat casualty care and military readiness.
    Keywords:  citation analysis; emergency medicine; graduate medical education; military medicine; scholarly activity
  25. Brain Sci. 2021 Aug 17. pii: 1077. [Epub ahead of print]11(8):
      BACKGROUND: Inflammatory markers association with many diseases is the subject of many articles and reviews. This study presents a comprehensive bibliometric review and visualization analysis of inflammatory biomarkers (IB) in the context of febrile seizure (FS) patients.METHODS: The study focused on IB in FS using (1) bibliometric analysis specific indicators and maps in order to analyze and present the network of authors, journals, universities, and countries, and (2) automated literature screening and unsupervised clustering approach for filtering and topic cluster identification.
    RESULTS: We conducted a literature mining search on FS research, specifically IB in the context of FS, using the automated tools VOSviewer and Bibliometrix. Indices of the inflammatory response (in the context of febrile seizures) identified by the literature mining are (pro/anti-inflammatory) cytokines, such as interleukin IL-1β, IL-6, IL-8, I-10, IL-22, tumor necrosis factor (TNF-α), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet count (PLT), and red blood cell distribution width (RDW). The resulted bibliometric maps and topic clusters offer a comprehensive overview, the status and leading trends on existing research of inflammatory biomarkers in FS.
    CONCLUSION: The analysis using bibliometrics and review with graphical presentations can be useful in investigating and (better) understanding the relationship between FS and IB.
    Keywords:  VOSviewer; bibliometric; clustering; febrile seizures; inflammatory biomarkers; literature mining; visualization
  26. J Oral Rehabil. 2021 Aug 25.
      BACKGROUND AND OBJECTIVES: To present a world panorama of the published papers on bruxism in children and adolescents, emphasizing the characteristics of studies related to the sleep features of these patients.METHODS: Literature searches were conducted in six databases without language or date restrictions. Data on the titles, types of study, main subjects, countries of origin, keywords, years of publication, authors and their network collaborations, journals, and sleep studies were extracted and analyzed in VantagePoint™ software.
    RESULTS: A total of 725 studies met the eligibility criteria. Most included only children (75.31%), with observational design (66.34%), and risk or etiology (53.93%) as the main subject. Brazil (18.06%) and Brazilian authors (54.84%) had the largest number of studies, with a low amount of network collaboration. The Journal of Oral Rehabilitation published most of the studies (6.2%); publications in this field have grown considerably from 2000 to 2020. Of the studies, 123 (16.96%) included sleep studies; night sweating, restless sleep, sleep talking, mouth breathing, snoring, obstructive sleep apnea syndrome, sleep-disordered breathing, nightmares, poor sleep quality and duration, and daytime naps were significantly associated with bruxism in most.
    CONCLUSION: Studies on bruxism in children and adolescents have increased in the past 20 years, with most being observational, and risk or etiology as the main subject. Brazil and the Journal of Oral Rehabilitation have published most in the field. Sleep studies have shown some features associated with bruxism, such as night sweating, restless sleep, somniloquy, snoring, breathing problems, nightmares, daytime naps, and poor sleep quality and duration.
    Keywords:  adolescent; bibliometrics; bruxism; children; sleep; sleep bruxism
  27. Int J Dent. 2021 ;2021 3463434
      Objectives: The level of evidence (LOE) of Saudi dental research from 2000 to 2020 was evaluated, and factors associated with the LOE were determined.Methods: This study was a systematic review. PubMed, Web of Science, and Medline databases were utilized to retrieve available dental articles published in English between January 2000 and May 2020. The inclusion criteria consisted of clinical studies conducted in Saudi Arabia with at least one Saudi dental affiliation. The retrieved eligible articles were evaluated independently by two reviewers using a modified Oxford LOE scale. The LOE of the studies was compared between the last two decades.
    Results: Of the 7237 articles identified, 1557 articles met the inclusion criteria. Approximately 78% of the published articles reported Level IV evidence. A higher trend toward Level I, II, and III publications has occurred in recent years (i.e., 2010-2020). However, no statistically significant difference existed in LOE proportions between the two decades. The presence of international collaboration and high journals' impact factor was significantly associated with a higher LOE.
    Conclusion: Most published dental research studies were low LOE studies (i.e., Level IV). National and international collaboration is highly encouraged as this is a factor, according to our findings, that would be a positive addition toward publishing dental research of a higher LOE in Saudi Arabia.
  28. Arch Dermatol Res. 2021 Aug 23.
      Although dermatology is one of the most competitive specialties to match into, there is limited transparency in the residency match process. In this retrospective cohort study of 2234 allopathic medical graduates, we identify applicant characteristics associated with matching into research oriented dermatology programs. Many of the statistically significant variables in our study, including PhD/MD status, graduating from a Top-25 NIH funded medical school, increasing total number of pre-residency publications (PRPs), and increasing number of high-impact PRPs, correlate with future academic employment. Although literature shows an association between an increasing number of first author PRPs and future academic employment, we did not find number of first or last author PRPs to be predictive of matching into a research oriented residency program. A more comprehensive evaluation of an applicant's research output, considering both the final products of an applicant's research endeavors and an applicant's role in various projects, may better approximate an applicant's commitment to academics.
    Keywords:  Academics; NIH funding; Research output; Residency match
  29. J Healthc Eng. 2021 ;2021 9739219
      The emergence of machine learning (ML) and blockchain (BC) technology has greatly enriched the functions and services of healthcare, giving birth to the new field of "smart healthcare." This study aims to review the application of ML and BC technology in the smart medical industry by Web of Science (WOS) using bibliometric visualization. Through our research, we identify the countries with the greatest output, the major research subjects, funding funds, and the research hotspots in this field. We also find out the key themes and future research areas in application of ML and BC technology in healthcare area. We reveal the different aspects of research under the two technologies and how they relate to each other around five themes.
  30. Int J Environ Res Public Health. 2021 Aug 20. pii: 8795. [Epub ahead of print]18(16):
      Six Sigma has been widely used in the health field for process or quality improvement, constituting a quite profusely investigated topic. This paper aims at exploring why some studies have more academic and societal impact, attracting more attention from academics and health professionals. Academic and societal impact was addressed using traditional academic metrics and alternative metrics, often known as altmetrics. We conducted a systematic search following the PRISMA statement through three well-known databases, and identified 212 papers published during 1998-2019. We conducted zero-inflated negative binomial regressions to explore the influence of bibliometric and content determinants on traditional academic and alternative metrics. We observe that the factors influencing alternative metrics are more varied and difficult to apprehend than those explaining traditional impact metrics. We also conclude that, independently of how the impact is measured, the paper's content, rather than bibliometric characteristics, better explains its impact. In the specific case of research on Six Sigma applied to health, the papers with more impact address process improvement focusing on time and waste reduction. This study sheds light on the aspects that better explain publications' impact in the field of Six Sigma application in health, either from an academic or a societal point of view.
    Keywords:  academic impact; altmetrics; health; healthcare; lean six sigma; meta-analysis; six sigma
  31. Int J Environ Res Public Health. 2021 Aug 13. pii: 8578. [Epub ahead of print]18(16):
      The COVID-19 pandemic has wreaked havoc in every country in the world, with serious health-related, economic, and social consequences. Since its outbreak in March 2020, many researchers from different fields have joined forces to provide a wide range of solutions, and the support for this work from artificial intelligence (AI) and other emerging concepts linked to intelligent data analysis has been decisive. The enormous amount of research and the high number of publications during this period makes it difficult to obtain an overall view of the different applications of AI to the management of COVID-19 and an understanding of how research in this field has been evolving. Therefore, in this paper, we carry out a scientometric analysis of this area supported by text mining, including a review of 18,955 publications related to AI and COVID-19 from the Scopus database from March 2020 to June 2021 inclusive. For this purpose, we used VOSviewer software, which was developed by researchers at Leiden University in the Netherlands. This allowed us to examine the exponential growth in research on this issue and its distribution by country, and to highlight the clear hegemony of the United States (USA) and China in this respect. We used an automatic process to extract topics of research interest and observed that the most important current lines of research focused on patient-based solutions. We also identified the most relevant journals in terms of the COVID-19 pandemic, demonstrated the growing value of open-access publication, and highlighted the most influential authors by means of an analysis of citations and co-citations. This study provides an overview of the current status of research on the application of AI to the pandemic.
    Keywords:  COVID-19; VOSviewer; artificial intelligence; machine learning; scientometrics; text mining
  32. Tissue Eng Part C Methods. 2021 Aug 27.
      BACKGROUND: Skeletal muscle tissue engineering (SMTE) is of great significance in the study of skeletal muscle physiology and pathology, which could be used in skeletal muscle graft. The scientometric analysis of SMTE can help researchers to quickly understand the evolutive history, status, novelties, and trend of this field. Experiment: In this study, we performed a scientometric study that can be used to construct and visualize networks of SMTE by using VOSviewer. A total of 1384 documents published between 1994 and 2020were retrieved and analyzed.RESULTS: Our results showed that number of publications in SMTE has increased slowly from 1994 to 2014 and has increased rapidly from 2015 to 2020. The geographical distribution of publications in term of total publications about SMTE is concentrated in Europe and the United States. The most productive institution was University of Michigan, while Harvard University and the University of Pittsburgh was ranked the second and third places. SMTE influenced a wide spectrum of disciplines including Biology and Medicine, and Physical Sciences. In addition, the research hotspot of SMTE were expanding from seed cells to the combination with advanced strategies (electrostatic spinning, bioprinting, and materials) for emulating the highly bionic engineered skeletal muscle tissues.
    CONCLUSIONS: This study provided a unique perspective for understand the history and trends of SMTE, which could help to promote the rapid development of the field.
  33. United European Gastroenterol J. 2021 Aug 25.
      AIM: Many therapeutic options for inflammatory bowel disease (IBD) emerged during the last 2 decades, along with the rise in disease prevalence and incidence. We aimed at assessing the published literature on different treatment options in that period. Special attention was attributed to specific medication mechanisms and geographic diversity.MATERIALS AND METHODS: We have queried PubMed for all available IBD-related entries published during 2000-2020. The following data were extracted for each entry: PubMed unique article ID (PMID), title, publishing journal, abstract text, keywords (if any), and authors' affiliations. Two gastrointestinal specialists decided in consensus on a list of terms to classify entries. The terms belonged to five treatment groups: medical, surgical, dietary, microbiome manipulation, and complementary medicine. The medical and complementary medicine groups were further sub-classified. Annual trends of publications for the years 2000-2020 were plotted for different treatment types. The slopes of publication trends were calculated by fitting regression lines to the annual number of publications.
    RESULTS: Overall, 77,505 IBD entries were published between 2000 and 2020. Medical treatment showed the highest number of total publications 21,540/77,505 (27.8%), followed by surgical 7605/77,505 (9.8%), microbiome research 5260/77,505 (6.8%), dietary 4819/77,505 (6.2%), and complementary medicine treatment 762/77,505 (1.0%). Interestingly, since 2012 there is a steep rise in microbiome publications that outnumbered surgery in the last 2 years. Trend analysis of medical treatment showed that biologics had the steepest slope (57.5, p < 0.001), followed by immunomodulators (4.9, p < 0.001), small molecules (3.9, p < 0.001), and 5-ASA (3.8, p < 0.001).
    CONCLUSION: According to our high-level publications trend analysis, the past 2 decades certainly deserve the reference as the "biologic era", as publications regarding biological therapy outnumbered all other treatment options. Interestingly, though very popular among patients, complementary medicine was not studied with correlation to its' acceptance among patients.
    Keywords:  Crohn disease; complementary therapies; drug therapy; inflammatory bowel disease; microbiome; nutrition; surgery; ulcerative colitis
  34. An Acad Bras Cienc. 2021 ;pii: S0001-37652021000601801. [Epub ahead of print]93(suppl 3): e20201948
      The issue of publication of articles by researchers in the universe of scientific publications, has become over the last decades, increasingly asymmetrical among the parties involved (author, Author's institution, Development agencies, Magazine / Publisher, and referees). Here, I analyzed to what extent are all the parts involved in the process of scientific publication equally balanced, and the gains and losses among parts involved during the process. The analysis points that the gains and losses among parts involved are quite asymmetric. I conclude that there are advantages, disadvantages and costs that should be addressed at a global level to better balance the process of publication and that should have some adjustments to better balance of the parts involved in the process. All parts involved should search for a more equilibrated system of publishing, since, now, the system is strongly asymmetric among the parts involved in scientific publication. It is clear is that this is not a simple subject, but possible changes are quite simple and desirable.
  35. J Pharm Pract. 2021 Aug 27. 8971900211040438
      Purpose. To summarize the most highly esteemed, peer-reviewed, infectious diseases (ID) pharmacotherapy articles published in 2020. Summary. Members of the Houston Infectious Diseases Network (HIDN) nominated articles that were deemed to have noteworthy contributions to ID pharmacotherapy in 2020, including those on coronavirus disease 2019 (COVID-19) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). To select the most significant articles of 2020, a survey was created and distributed to members of the Society of Infectious Diseases Pharmacists (SIDP) to vote on their top 10 articles of general ID and COVID-19 pharmacotherapy and one noteworthy HIV/AIDS publication. A total of 40 articles were nominated by HIDN: 35 articles pertaining to general ID/COVID-19 pharmacotherapy and 5 articles with HIV/AIDS involvement. Of the 247 SIDP members who responded to the survey, 205 and 42 members voted for general ID/COVID-19 pharmacotherapy articles and HIV/AIDS related articles, respectively. The top publications are summarized. Conclusion. In a taxing year of a global pandemic, the abundant and rapid distribution of ID literature has made it challenging for clinicians to stay informed of significant publications across the ID spectrum. This review summarizes significant ID-related publications in 2020 with the goal of aiding clinicians in staying up to date on the most relevant publications in ID pharmacotherapy.
    Keywords:  COVID-19; HIV; antimicrobials; stewardship; survey
  36. Nature. 2021 Aug;596(7873): 486
    Keywords:  Authorship; Careers; Publishing
  37. PLoS One. 2021 ;16(8): e0256742
      BACKGROUND: Women are underrepresented at higher levels of promotion or leadership despite the increasing number of women physicians. In surgery, this has been compounded by historical underrepresentation. With a nation-wide focus on the importance of diversity, our aim was to provide a current snapshot of gender representation in Canadian universities.METHODS: This cross-sectional online website review assessed the current faculty listings for 17 university-affiliated academic surgical training departments across Canada in the 2019/2020 academic year. Gender diversity of academic surgical faculty was assessed across surgical disciplines. Additionally, gender diversity in career advancement, as described by published leadership roles, promotion and faculty appointment, was analyzed.
    RESULTS: Women surgeons are underrepresented across Canadian surgical specialties (totals: 2,689 men versus 531 women). There are significant differences in the gender representation of surgeons between specialties and between universities, regardless of specialty. Women surgeons had a much lower likelihood of being at the highest levels of promotion (OR: 0.269, 95% CI: 0.179-0.405). Men surgeons were statistically more likely to hold academic leadership positions than women (p = 0.0002). Women surgeons had a much lower likelihood of being at the highest levels of leadership (OR: 0.372, 95% CI: 0.216-0.641).
    DISCUSSION: This study demonstrates that women surgeons are significantly underrepresented at the highest levels of academic promotion and leadership in Canada. Our findings allow for a direct comparison between Canadian surgical subspecialties and universities. Individual institutions can use these data to critically appraise diversity policies already in place, assess their workforce and apply a metric from which change can be measured.
  38. Eur Heart J Qual Care Clin Outcomes. 2021 Aug 24. pii: qcab058. [Epub ahead of print]
      BACKGROUND: The geographic representation of investigators and participants in heart failure (HF) randomized clinical trials (RCTs) may not reflect the global burden of disease.AIMS: We assessed the geographic diversity of RCT leaders and explored associations with geographic representation of enrolled participants among impactful HF RCTs.
    METHODS AND RESULTS: We searched MEDLINE, EMBASE, and CINAHL for HF RCTs published in journals with impact factor ≥10 between January 2000 and June 2020. We used the Jonckheere-Terpstra test to assess temporal trends and multivariable logistic regression models to explore associations between predictors and outcomes. There were 414 eligible RCTs. Only 80 of 828 trial leaders (9.7%; 95% CI: 7.8% to 11.8%), and 453 of 4656 collaborators (9.7%; 95% CI: 8.8% to 10.6%) were from outside Europe and North America, with no change in temporal trends and greater disparities in large RCTs. The adjusted odds of trial leadership outside Europe and North America were lower with industry funding (aOR: 0.33; 95% CI: 0.15 to 0.75; P = 0.008). Among 157,416 participants in whom geography was reported, only 14.5% (95% CI: 14.3% to 14.7%) were enrolled outside Europe and North America, but odds of enrolment were ten-fold greater with trial leadership outside Europe and North America (aOR: 10.0; 95% CI 5.6-19.0; P < 0.001).
    CONCLUSIONS: Regions disproportionately burdened with HF are under-represented in HF trial leadership, collaboration, and enrolment. RCT leadership outside Europe and North America is independently associated with participant enrolment in under-represented regions. Increasing research capacity outside Europe and North America could enhance trial diversity and generalizability.
    Keywords:  Authorship; Collaboration; Diversity; Geography; Randomized Controlled Trials
  39. PLoS One. 2021 ;16(8): e0256577
      BACKGROUND: Since 2008, the Canadian Institutes of Health Research (CIHR) has mandated that studies it funds either in whole or in part are required to publish their results as open access (OA) within 12 months of publication using either online repositories and/or OA journals. Yet, there is evidence that authors are poorly compliant with this mandate. Specifically, there has been an apparent decrease in OA publication after 2015, which coincides with a change in the OA policy during the same year. One particular policy change that may have contributed to this decline was lifting the requirement that authors deposit their article in an OA repository immediately upon publication. We investigated the proportion of OA compliance of CIHR-funded studies in the period before and after the policy change of 2015 with manual confirmation of both CIHR funding and OA status.METHODS AND FINDINGS: We identified CIHR-funded studies published between the years 2014 to 2017 using a comprehensive search in the Web of Science (WoS). We took a stratified random sample from all four years (i.e. 2014 to 2017), with 250 studies from each year. Two authors independently reviewed the final full-text publications retrieved from the journal web page to determine to confirm CIHR funding, as indicated in the acknowledgements or elsewhere in the paper. For each study, we also collected bibliometric data that included citation count and Altmetric attention score Statistical analyses were conducted using two-tailed Fisher's exact test with relative risk (RR). Among the 851 receiving CIHR funding published from 2014 to 2017, the percentage of CIHR-funded studies published as OA significantly decreased from 79.6% in 2014 to 70.3% in 2017 (RR = 0.88, 95% CI: 0.79-0.99, P = 0.028). When considering all four years, there was no significant difference in the percentage of CIHR-funded studies published as OA in both 2014 and 2015 compared to both 2016 and 2017 (RR = 0.97, 95% CI: 0.90-1.05, P = 0.493). Additionally, OA publications had significantly higher citation count (both in year of publication and in total) and higher attention scores (P<0.05).
    CONCLUSIONS: Overall, we found that there was a significant decrease in the proportion of CIHR funded studies published as OA from 2014 compared to 2017, though this difference did not persist when comparing both 2014-2015 to 2016-2017. The primary limitation was the reliance of self-reported data from authors on CIHR funding status. We posit that this decrease may be attributable to CIHR's OA policy change in 2015. Further exploration is warranted to both validate these studies using a larger dataset and, if valid, investigate the effects of potential interventions to improve the OA compliance, such as use of a CIHR publication database, and reinstatement of a policy for authors to immediately submit their findings to OA repositories upon publication.
  40. Vet Sci. 2021 Aug 07. pii: 159. [Epub ahead of print]8(8):
      Women's participation and completion at veterinary schools has increased globally for the past few decades. However, increased female graduates have not translated into similar patterns of academic staffing. The gender distribution within each academic level at eight accredited veterinary faculties in Australia and New Zealand, 38 accredited faculties in the USA and Canada and 98 accredited faculties in Europe were analyzed. Women occupied 47.9%, 45.5% and 47.5% of the academic positions in Australia/New Zealand, the USA/Canada and Europe, respectively. Compared to their male counterparts, female academics were more likely to hold the lower ranked positions. The gender distribution is skewed toward men in the senior positions at or above associate professor level in all analyzed regions. The findings of this study confirm gender inequality in academic progression meaning there is a continued need to develop strategies to eliminate inequity in veterinary science faculties worldwide.
    Keywords:  academia; gender equality; veterinary science
  41. Entropy (Basel). 2021 Jul 23. pii: 944. [Epub ahead of print]23(8):
      Text mining is applied to 510 articles on econophysics to reconstruct the lexical evolution of the discipline from 1999 to 2020. The analysis of the relative frequency of the words used in the articles and their "visualization" allow us to draw some conclusions about the evolution of the discipline. The traditional areas of research, financial markets and distribution of wealth, remain central, but they are flanked by other strands of research-production, currencies, networks-which broaden the discipline by pushing towards a dialectical application of traditional concepts and tools drawn from statistical physics.
    Keywords:  correspondence analysis; lexical evolution of econophysics; text as data
  42. Toxics. 2021 Jul 28. pii: 176. [Epub ahead of print]9(8):
      The growth of industrialization has led to an increase in the production of highly contaminated wastewater. Industrial wastewater contains highly complex compounds varying in characteristics and required to be treated before its discharge into a water medium from various industries. However, the efficiency of the treated wastewater from the toxicity reduction perspective is unclear. In order to overcome this barrier, toxicity assessment of the industrial wastewater before and after treatment is crucial. Thus, in this study, a scientometric analysis has been performed on the toxicity assessment of industrial wastewater and sludges, which have been reported in the literature. Web of Science (WoS) core collection database has been considered the main database to execute this analysis. Via the search of pre-researched keywords, a total number of 1038 documents were collected, which have been published from 1951 to 2020. Via CiteSpace software and WoS analyser, these documents went under analysis regarding some of the scientometry criteria, and the detailed results obtained are provided in this study. The total number of published documents on this topic is relatively low during such a long period of time. In conclusion, the need for more detailed contributions among the scientific and industrial communities has been felt.
    Keywords:  industry; scientometry; sludge; toxicology; wastewater
  43. Bull Environ Contam Toxicol. 2021 Aug 23.
      In this letter, we formally replied to the comments on our recently published paper "A scientometric analysis of recent literature on arsenic bioaccumulation and biotransformation in marine ecosystems" with evidence and facts.
    Keywords:  Arsenic; CiteSpace; Marine ecosystems; WoS
  44. J Am Coll Cardiol. 2021 Aug 31. pii: S0735-1097(21)05533-9. [Epub ahead of print]78(9): 898-909
      BACKGROUND: Despite the increase in the number of female physicians across most specialties within cardiology, <10% of clinical cardiac electrophysiology (EP) fellows are women.OBJECTIVES: This study sought to determine the factors that influence fellows-in-training (FITs) to pursue EP as a career choice and whether this differs by gender.
    METHODS: The authors conducted an online multiple-choice survey through the American College of Cardiology to assess the decision factors that influence FITs in the United States and Canada to pursue cardiovascular subspecialties.
    RESULTS: A total of 933 (30.5%) FITs completed the survey; 129 anticipated specializing in EP, 259 in interventional cardiology (IC), and 545 in a different field or were unsure. A total of 1 in 7 (14%) FITs indicated an interest in EP. Of this group, more men chose EP than women (84% vs 16%; P < 0.001). The most important factor that influenced FITs to pursue EP was a strong interest in the field. Women were more likely to be influenced by having a female role model (P = 0.001) compared with men. After excluding FITs interested in IC, women who deselected EP were more likely than men to be influenced by greater interest in another field (P = 0.004), radiation concerns (P = 0.001), lack of female role models (P = 0.001), a perceived "old boys' club" culture (P = 0.001) and discrimination/harassment concerns (P = 0.001).
    CONCLUSIONS: Women are more likely than men to be negatively influenced by many factors when it comes to pursuing EP as a career choice. Addressing those factors will help decrease the gender disparity in the field.
    Keywords:  culture; discrimination; diversity; gender; training; women
  45. AIDS Res Ther. 2021 Aug 25. 18(1): 54
      BACKGROUND: A North-South (N-S) research collaboration is one way through which research capacity of developing countries can be strengthened. Whereas N-S collaboration in HIV/AIDS area may result in research capacity strengthening of Southern partners, it is not clear what factors are associated with this type of collaboration. The study aims to characterize N-S research collaboration focusing on HIV/AIDS and to determine factors associated with such N-S research collaborations.METHODS: Clinical trial data on HIV/AIDS-related studies conducted between 2000 and 2019 were obtained from Using these data, we characterized N-S collaborative studies focusing on HIV/AIDS and summarized them using frequencies and percentages. To determine factors associated with these studies, we used logistic regression and reported results as adjusted odds ratios with Wald 95% confidence intervals.
    RESULTS AND DISCUSSION: Of the 4,832 HIV/AIDS-related studies retrieved from the registry, less than one-quarter (n = 1133, 23%) involved a Southern institution, with 77% of these studies classified as N-S collaborations. Majority of these studies have single PI (50%), are conducted at single location (39%); have large sample sizes (41%); are federally-funded (32%) or receive funding from other sources (32%); are intervention studies (64%); and involve a mixture of male and female participants (58%) and adult participants (54%). Single PIs (as opposed to multiple PIs) were more likely to be from the North than South institution (odds ratio = 5.59, 95%CI: 4.16 - 11.57). Trend analyses showed that N-S research collaborations produced HIV/AIDS-related studies at a faster rate than S-S research collaborations. N-S collaborations involving female or children produced HIV/AIDS-related studies between 2000 and 2019 at a significantly faster rate than S-S collaborations involving females and children during the same period. Holding other factors constant, N-S collaborative research focusing on HIV/AIDS are associated with: multiple PIs as opposed to single PI, multiple institutions as opposed to a single institution, multiple locations as opposed to a single location, large number of participants as opposed to small sample sizes, and public funding as opposed to industry funding. Almost half of these studies had a Northern PI only, about one-third had a Southern PI only, and much fewer had PIs from both North and South. However, these studies were less likely to receive funding from other sources than industry funding.
    CONCLUSIONS: HIV/AIDS-related research is increasingly becoming a more collaborative global research involving more N-S collaborations than S-S collaborations. Factors associated with N-S collaborative studies focusing on HIV/AIDS include multiple PIs, institutions, and locations; large sample sizes; publicly funded; and involve vulnerable populations such as women and children. Whereas almost half of these studies have a Northern PI only, about one-third have a Southern PI only, and much fewer have PIs from both North and South. Our results inform future design and implementation of N-S research collaborations in this area. Suggestions for improvement of registry are provided.
    Keywords:  Clinical trials; HIV/AIDS; Logistic regression; North–South collaborations; Research capacity strengthening