bims-evares Biomed News
on Evaluation of research
Issue of 2021‒07‒11
forty-seven papers selected by
Thomas Krichel
Open Library Society

  1. Breast Dis. 2021 Jun 28.
      BACKGROUND: Male breast cancer is a considerably rare condition and only accounts for 1% of all breast cancer cases. Due to limited public awareness, the condition is likely to present late, leading to late diagnosis and treatment worsening morbidity and mortality. This article aims to identify the focus and most influential research on male breast cancer. Objective Identify the most influential papers in male breast cancer.METHODS: Search on Web of Science using the search terms 'Male', 'Breast Cancer' and "Male breast cancer" to identify all full manuscripts in English language and were ranked by the total number of citations. The top 100 articles were then further analysed according to subject, author, journal, year and country of publications.
    RESULTS: The mean number of citations per paper was 96. Most cited paper was by Thorlacius, S et al. evaluating the relationship between BRCA2 and female breast cancer, prostate cancer, pancreatic cancer and ovarian cancer. Cancer is the journal with the most published papers and received most citations in the male breast cancer research field. The USA contributed 49 of the manuscripts in the top 100. The most studied topic was risk factors for male breast cancer, with 20 articles.
    CONCLUSIONS: The most cited papers identified in this study described the advance in the knowledge of genetics and epidemiology in male breast cancer and has led to improvements in the 4 management of the disease. Most of the highly cited articles in this field were published in high impact journals and had accumulated at least 100 citations to date, reflecting their quality and impact. By collating the most influential publications in this field, this analysis can serve to identify knowledge gaps in male breast cancer research as well as to help identify what makes a paper impactful and citable.
    Keywords:  xx
  2. Front Psychiatry. 2021 ;12 661108
      Background: Exercise is medicine. Multiple studies on the effects and mechanisms of exercise in treating depression among teenagers and adolescents have been widely reported. However, literature involving scientometric analysis of this topic is sparse. Here, we endeavored to conduct a bibliometric study and visualization analysis to give a bird's-eye view of publications between 2000 and 2020 on exercise therapy treating depression. Methods: Relevant original publications were obtained from the Science Citation Index Expanded in the Web of Science Core Collection (WoSCC) database between 2000 and 2020. CiteSpace (5.7.R 5) and VOSviewer (1.6.16) software were used to perform bibliometric analysis of countries, institutions, categories, journals, authors, references, and keywords involved in this topic. Results: A total number of 975 articles on this field were retrieved from the WoSCC database and we identified an overall increase in the amount of publications over the past two decades, with the United States and Harvard University leading the field. Most related publications were published in the journals with a focus on sport, medicine, rehabilitation, psychology, and health, as represented by the dual-map overlay. A series of authors and co-cited authors were identified as main contributors in the exercise-depression-teenager domain. Three major clusters were explored based on the reference co-citation analysis: "exercise," "suicide," and "concussion". Conclusions: Current concerns and hotspots of exercise intervention in depression treatments were summarized by "individual level," "social level," "role of exercise," and "research quality." We considered that the following four directions were potential future perspectives: "research on the effect of specific exercise intervention," "research on the essence of exercise and sports," "research on the combination mode of 'exercise + X'," and "research on the micro and molecular level," which should receive more attention.
    Keywords:  bibliometric; depression; exercise intervention; teenagers; visualization analysis
  3. J Chin Med Assoc. 2021 Jun 25.
      BACKGROUND: Citation analysis can provide a historical perspective in the advancement of research, evolution, and areas of research. Taiwan exhibits rigorous academic and scientific activities in dentistry; however, based on its empirical contribution in research, there is no report in the literature analyzing the top-cited papers published by authors affiliated with Taiwan institutes. The purpose of this study was to analyze the citation characteristics of the top 100 most-cited articles published in dentistry with author(s) affiliated with Taiwan institutes.METHODS: The Scopus® database was used to search the qualified articles with authors from Taiwan published in dental journals. The bibliometric parameters, including year of publication, study design, research fields, citation half-life, self-citation, institute of origin and international collaboration were analyzed. Multivariable linear regression in generalized linear model was used to find associate factors related to trends of citation counts.
    RESULTS: The top 100 most-cited article were determined by analyzing 7,667 articles from the Scopus® database. The steadily increasing trends were observed in the number and percentage of articles of author(s) affiliated with Taiwan institutes to the world. The most common study design was the in vitro research (55 %). The majority citation half-life is 3 - 5 and 6 - 8 year, and self-citation counts was between 1 - 5 times (n = 26). The percentage of international collaboration of these most-cited articles was 32 %, and the main collaboration country was USA. By using multivariable linear regression in the generalized linear model, the associated factors, study design and self-citation, were significantly associated with the escalating trends of citation counts.
    CONCLUSION: This is the first study that provides valuable information in the dentistry regarding the academic activity, and empirical contribution of author(s) affiliated with Taiwan institutes in the world. The trends of citation characteristics were significantly correlated with study design and self-citation of these articles.
  4. Ann Geriatr Med Res. 2021 Jul 07.
      Background: Bibliometric analysis is important to guide future research priorities. We aimed to evaluate the most relevant scientific research on COVID-19 and older adults, analyze the current hot topics and identify the 50 most cited publications.Methods: Articles published between December 2019-March 17, 2021 were analyzed. A list was obtained that contained the terms "COVID-19" or "Novel Coronavirus" or "SARS-CoV-2" or "2019-nCoV" and "geriatrics" or "older adults" or "elderly" in the title, abstract, keywords, or keywords plus. Original research articles, reviews, editorial materials, letters were included. The information for the articles contained the year, journal, title, author, country, affiliation, keywords, document type, and counts of citation. VOSviewer was used to analyze the keywords. The most cited 50 articles were identified.
    Results: Totally 784 publications were included. The keywords that appeared most were "COVID-19" and "older adults," which had a strong link to "social isolation," "dementia," "mortality," and "loneliness." The most active (40.8%) and most cited (1,578) country was the United States. The journal with the largest number of publications (22.7%) and citations (947) was the Journal of the American Geriatric Society. The most researched (84.0%) and most cited area was geriatrics-gerontology (2,882). The median number of citations for the most cited 50 articles was 46.8.
    Conclusion: The current bibliometric analysis provides information about the quality and research areas of the studies concerning COVID-19 and older adults that have been published so far. Social and psychological support, nutrition, vaccines, and telemedicine may be hot research topics for the future.
    Keywords:  Bibliometrics; COVID-19; Web of Science; geriatrics; older adults
  5. J Pain Res. 2021 ;14 1985-2000
      Objective: This study aims to explore the trend and knowledge mapping of acupuncture for migraine through bibliometrics.Methods: It retrieved the literature on acupuncture for migraine in the Web of Science database from 2000 to 2019, and then resorted to CiteSpace to conduct bibliometric analysis to attain the knowledge mapping.
    Results: The total number of publications each year has increased year by year, and the average annual growth rate from 2000 to 2009 was 15.57%, while from 2010 to 2019 was 6.35%, with a faster growth rate from 2000 to 2009. According to the cluster analysis of institutions, authors, cited references, and keywords, 10, 7, 12, and 10 categories were gained from 2000 to 2019. The most productive countries, institutions, and authors are the USA and China, Technical University of Munich and Beijing University of Chinese Medicine, Linde K and Liang FR from 2000 to 2019, whose frequency is 119/103, 28/24, and 28/24, respectively. However, the most important of them are Canada, Sichuan University, and Witt CM. Owing to their highest centrality, they are 0.86, 0.54, and 0.27 separately. Moreover, cited references that contributed to the most co-citations are Linde K (2005), yet, the most vital cited reference is Karst M (2001). Keywords such as migraine, acupuncture, headache, pain, and randomized controlled trial are the most frequently used. However, needle acupuncture is the crucial keyword. In the cluster analysis of institutions, authors, cited references, and keywords from 2000 to 2019, the largest cluster categories are #0 migraine prophylaxis, #1 randomized controlled trial, #0 episodic migraine, and #0 topiramate treatment. Then, randomized controlled trials of acupuncture prevention and treatment of migraine are the most important research content in this field.
    Conclusion: Through the bibliometric analysis of the research on acupuncture for migraine in the Web of Science database in the past 20 years, the trends and the Knowledge Graph of the country, institution, author, cited reference, and the keyword are acquired, which have an important guiding significance for quickly and accurately positioning the key information in the field.
    Keywords:  CiteSpace; acupuncture; bibliometric analysis; migraine; scientific knowledge graph
  6. Biomed Res Int. 2021 ;2021 5573790
      Worldwide, iron deficiency is a common form of micronutrient deficiency with a high individual and societal cost. There are considerable knowledge and practice gaps in the diagnosis and treatment of iron deficiency. Bibliometric analysis examines the published body of knowledge of a subject in an objective fashion. The Web of Science Core Collection was searched to retrieve the 100 most cited papers on the topic of iron deficiency, and the key metrics of each paper were extracted. A keyword study was performed using VOSviewer 1.6.10 software, which provided a visual mapping of the network of keyword cooccurrences. The papers were published between 1964 and 2017 and were cited an average of 636 times. They were contributed by authors from 119 different countries/regions, with the largest contributing country being the United States. 29 institutions contributed at least 6 publications each, and 4 researchers authored or coauthored at least 5 papers. Keyword analysis suggests that the most cited topics could be grouped into 4 categories: (1) epidemiologic research of the global burden of iron deficiency, (2) clinical aspects of iron deficiency anemia, (3) iron metabolism, and (4) the impact of iron deficiency on children. Identification of the most impactful studies in the field of iron deficiency may be helpful to practitioners interested in improving their knowledge base. Compared to bibliometric studies performed on other topics, the medical literature of iron deficiency is mature, as evidenced by the high citation rate of the top 100 papers. Despite the high worldwide prevalence of iron deficiency, the top cited papers are dominated by a relatively small number of countries and institutions. Interestingly, however, the most cited authors in this study do not overlap with the most cited institutions.
  7. Cell Stress Chaperones. 2021 Jul 07.
      HSPB5 (heat shock protein B5), also known as αB-crystallin, is one of the most widespread and populous of the ten human small heat shock proteins (sHsps). Over the past decades, extensive research has been conducted on HSPB5. However, few studies have statistically analyzed these publications. Herein, we conducted a bibliometric analysis to track the global research trend and current development status of HSPB5 research from the Web of Science Core Collection (WoSCC) database between 1985 and 2020. Our results demonstrate that 1220 original articles cited 54,778 times in 391 scholarly journals were published. Visualization analyses reveal that the Journal of Biological Chemistry was the most influential journal with 85 articles. The USA dominated this field with 520 publications (42.62%), followed by Japan with 149 publications (12.21%), and Kato contributed the largest number of publications. Most related publications were published in journals focusing on biochemistry molecular biology, cell biology, neurosciences neurology, and ophthalmology. In addition, keyword co-occurrence analyses identify three predominant research topics: expression of HSPB5, chaperone studies for HSPB5, and pathological studies of HSPB5. This study provides valuable guidance for researchers and leads to collaborative opportunities between diverse research interests to be integrated for HSPB5 research.
    Keywords:  Bibliometric methods; Citation count; Co-occurrence network; HSPB5; VOSviewer; αB-crystallin
  8. Environ Sci Pollut Res Int. 2021 Jul 07.
      Researchers have broadly studied textile waste, but the research topics development and performance trends in this study area are still unclear. A bibliometric analysis was conducted to explore the global scientific literature to determine state of the art on textile waste over the past 16 years. Data of publications output are identified based on the Web of Science (from 2015 to 2020). This study used VOSviewer to analyse collaboration networks among authors, countries, institutions, and author's keywords in identifying five main clusters. A total of 3296 papers in textile waste research were identified. In this study, a total of 10451 authors were involved in textile waste research, and 36 authors among them published more than ten research publications in the period of this study. China has been in a top position in textile waste research moving from 3 output publications in 2005 to 91 output publications in 2020. Indian Institute of Technology System IIT System was ranked first in terms of the total publication number (85 publications, 2.45%). Textile wastewater and adsorption are the most commonly used keywords that reflect the current main research direction in this field and received more attention in recent years. Based on keyword cluster analysis outputs, textile waste research can be categorized into five types of clusters, namely (1) pollutant compositions, (2) component of textile wastewater, (3) treatment methods for textile wastewater, (4) effect mechanism of textile wastewater, and (5) recyclability of textile waste.
    Keywords:  Bibliometric analysis; Review; Textile waste; Textile waste recycling; Textile wastewater; VOSviewer
  9. Learn Publ. 2021 Apr 08.
      This paper considers the pattens of international collaboration by analysing publications on COVID-19 published in the first 6 months of the pandemic. The data set comprised articles on COVID-19 indexed in the Web of Science Core Collection (WoS CC) downloaded four times between 1 April 2020 and 1 June 2020. The analysis of 5,827 documents revealed that 128 countries, 23,127 authors, and 6,349 institutes published on the pandemic. The data reveal that the three main publishing countries were the USA, China, and England with Italy closely following. Although publication was widely spread, most of the institutions with the highest volume of output were in China. Network analysis showed growth in international cooperation with an average degree of country/region cooperation rising to 23.06 by 1 June. There was also a clear core-periphery structure to international collaboration. Institutional collaboration was shown to be highly regionalized. The data reveal a high and growing incidence of international collaboration on the pandemic.
    Keywords:  COVID‐19; Scientific collaboration; contributors
  10. BMC Complement Med Ther. 2021 Jul 07. 21(1): 196
      BACKGROUND: Despite the increasing use of osteopathy, a manipulative complementary and alternative medicine therapy, in the general population, its efficacy continues to be debated. In this era of evidence-based practice, no studies have previously reviewed the scientific literature in the field to identify published knowledge, trends and gaps in empirical research. The aims of this bibliometric analysis are to describe characteristics of articles published on the efficacy of osteopathic interventions and to provide an overall portrait of their impacts in the scientific literature.METHODS: A bibliometric analysis approach was used. Articles were identified with searches using a combination of relevant MeSH terms and indexing keywords about osteopathy and research designs in MEDLINE and CINAHL databases. The following indicators were extracted: country of primary author, year of publication, journals, impact factor of the journal, number of citations, research design, participants' age group, system/body part addressed, primary outcome, indexing keywords and types of techniques.
    RESULTS: A total of 389 articles met the inclusion criteria. The number of empirical studies doubled every 5 years, with the United States, Italy, Spain, and United Kingdom being the most productive countries. Twenty-three articles were cited over 100 times. Articles were published in 103 different indexed journals, but more than half (53.7%) of articles were published in one of three osteopathy-focused readership journals. Randomized control trials (n = 145; 37.3%) and case reports (n = 142; 36.5%) were the most common research designs. A total of 187 (48.1%) studies examined the effects of osteopathic interventions using a combination of techniques that belonged to two or all of the classic fields of osteopathic interventions (musculoskeletal, cranial, and visceral).
    CONCLUSION: The number of osteopathy empirical studies increased significantly from 1980 to 2014. The productivity appears to be very much in sync with practice development and innovations; however, the articles were mainly published in osteopathic journals targeting a limited, disciplinary-focused readership.
    Keywords:  Bibliometrics; Case reports; Cohort; Craniosacral; Effects of intervention; Osteopathic manipulation; Osteopathy; Pilot studies; Randomized control trials; Visceral osteopathy
  11. Chemosphere. 2021 Jun 21. pii: S0045-6535(21)01739-2. [Epub ahead of print]284 131267
      Municipal wastewaters are abundant low-strength streams that require adequate treatment and disposal to ensure public and environmental health. This study aims to provide a comprehensive summary of municipal wastewater research in Europe in the 2010s in the form of bibliometric analysis. The work was based on the Science Citation Index Expanded (Web of Science) and carried out using the R-package bibliometrix for bibliometric data analysis and the software VOSviewer for science mapping. Analysing a dataset of 5645 publications, we identified the most influential journals, countries, authors, institutions, and publications, and mapped the co-authorship and keyword co-occurrence networks. Spain had produced the most publications while Switzerland had the highest average citations per publication. China was the most collaborative country from outside of Europe. Analysis of the most cited articles revealed the popularity of micropollutant removal in European municipal wastewater research. The keyword analysis visualized a paradigm shift from pollutant removal towards resource recovery and circular economy. We found that current challenges of resource recovery from municipal wastewater come from both technical and non-technical (e.g., environmental, economic, and social) aspects. We also discussed future research opportunities that can tackle these challenges.
    Keywords:  Bibliometric analysis; Circular economy; Europe; Micropollutant; Municipal wastewater; Resource recovery
  12. Clin Exp Optom. 2021 Jul 07. 1-7
      CLINICAL RELEVANCE: Examination of the literature can help answer the age-old question of the extent to which rigid contact lenses can be considered an art versus a science.BACKGROUND: This work aims to assemble rigid contact lens-related publication metrics to identify the most impactful papers, authors, institutions, countries and journals.
    METHODS: A search was undertaken of the Scopus database to identify rigid contact lens-related articles published since this lens type was first described in 1949. The 25 most highly cited papers were determined from the total list of 1,823 papers found. Rank-order lists by count were assembled for the 'top 25' in each of four categories: authors, institutions, countries and journals. A subject-specific rigid contact lens h-index (hRL-index) was derived for each author, institution, country and journal to serve as a measure of impact in the field. A short list of the top constituents in each category were ranked by hRL-index and tabulated.
    RESULTS: The most highly cited paper (467 citations) is entitled 'Risk factors and prognosis for corneal ectasia after LASIK', by Randleman et al. Karla Zadnik (hRL = 20; 32 papers) and Richard Hill (h = 10; 50 papers) are most impactful and prolific authors, respectively. The Ohio State University (hRL = 24; 96 papers) is the most impactful and prolific institution and the United States (hRL = 51; 680 papers) is the most impactful and prolific country. Optometry and Vision Science (hRL = 30; 233 papers) is the most impactful journal.
    CONCLUSIONS: Impactful authors, institutions, countries and journals in the field of rigid lenses are identified. Although there is perhaps an artistic element to rigid contact lens fitting, the solid literature base underpinning the field of rigid contact lenses revealed here belies the notion that rigid lenses fitting is more of an art than a science.
    Keywords:  Art and science; Rigid contact lenses; bibliometric analysis; h-index
  13. World Neurosurg. 2021 Jul 01. pii: S1878-8750(21)00956-6. [Epub ahead of print]
      OBJECTIVE: Our aim was to re-evaluate the h index of neurosurgical units in the UK and Ireland as it was 5-years since last published.METHODS: Using the Web of Science database we collated cumulative [1950-2020], 10-year [2011-2020], 5-year [2016 -2020] and 3-year [2018-2020] data for neurosurgical units in the UK and Ireland. Data included h index, number of publications and average number of citations.
    RESULTS: In total, 37 neurosurgical units were found in the UK and Ireland, which we ranked according h index. Since last reviewed 5-years ago some units have changed their position, while others have remained reasonably static. The top 5 units were the same for the h10 between 2015 and 2020. The h5 showed some variation in the top 5 compared with h10. We were also able to compare two other studies with similar methods but differing from ours.
    CONCLUSION: The h index for neurosurgical units is the most reliable bibliometric that demonstrates the academic standing and correlates well with amount of research grant obtained and size of department. It is particularly useful when calculated for the most recent 10-year and 5-year periods. Neurosurgical units change their rankings over time therefore it is important to update the tables periodically. We propose an online database with open access showing all h index and bibliometric data for neurosurgical units in the UK and Ireland. This could provide a 'live' and dynamic report of the academic standings of those units and could be used for grant applications and reviews.
    Keywords:  academic ranking; bibliometrics; h index; neurosurgery; publication metrics
  14. Ann Palliat Med. 2021 Jun;10(6): 6079-6091
      BACKGROUND: Infectious disease caused by carbapenem-resistant Enterobacteriaceae (CRE) has become one of the most serious challenges due to its high morbidity and mortality and research on it has aroused great concern worldwide in the last decade. Thus, a bibliometric analysis of relevant publications is needed to identify the situation of current investigations and prioritize the future research areas.METHODS: The current study retrieved articles related to CRE published between 2010 and 2020 from the Web of Science core collection database. The search strategy syntax included "carbapenem-resistant Enterobacteriaceae", "carbapenem-resistant Klebsiella pneumoniae", "carbapenemase producing Enterobacteriaceae" and "carbapenemase producing Klebsiella pneumoniae" which were searched in both Medical Subject Headings (MeSH) and titles. A bibliometric analysis was conducted using VOSviewer, Bibliographic Item Co-Occurrence Matrix Builder, gCLUTO and other machine learning tools. Key words, subject terms, contributions as well as collaborations were assessed. Moreover, hot off the press and future research trends were demonstrated.
    RESULTS: A total of 1,671 publications on CRE were finally included in the bibliometric analysis and 5 related theme clusters were identified which mainly focused on epidemiology, resistance mechanisms, antibiotics treatment and infection control. A total of 142 keywords occurred more than 5 times and the most frequent keyword was "carbapenem-resistant Enterobacteriaceae" with 247 occurrences and a total link strength of 559. The output on CRE has gradually increased during the last decade, and the USA has made the greatest contribution due to the 533 research papers. Agents that act against CRE, especially ceftazidime-avibactam (occurrences, 85; average publication year, 2018.26), and the early detection of CRE by genome sequencing techniques (occurrences, 97; average publication year, 2017.94) were emerging hot topics which would probably attract future research interest.
    CONCLUSIONS: The bibliometric analysis revealed that development of antibacterial agents, early etiological detection and genome sequencing techniques were the hotspots and would probably direct the future research directions which would also facilitate a better understanding of the epidemiology of drug-resistant bacteria and implementing the antibiotic stewardship program.
    Keywords:  Bibliometric analysis; carbapenem-resistant Enterobacteriaceae (CRE); carbapenemase; hotspot; trends
  15. Surg Neurol Int. 2021 ;12 223
      Background: Research is a central component of neurosurgical training and practice and is increasingly viewed as a quintessential indicator of academic productivity. In this study, we focus on identifying the current status and challenges of neurosurgical research in Iraq.Methods: An online PubMed Medline database search was conducted to identify all articles published by Iraq-based neurosurgeons between 2003 and 2020. Information was extracted in relation to the following parameters: authors, year of publication, author's affiliation, author's specialty, article type, article citation, journal name, journal impact factor, and topic. This data were then tabulated and analyzed.
    Results: Between 2003 and 2021, a total of 52 PubMed indexed papers were published from Iraq. All publications have been clustered in the period of 2012-2020. From 2012 to 2016, only four papers were published, one per year. The number of publications increased from 2017 to 2021, with an average of 12 publications per year. The most common article type was "case reports" (n = 14). Neurotrauma (n = 10) and vascular neurosurgery (n = 10) were the two most common topics. Most of the studies came from the city of Bagdad (n = 46), with just nine studies coming from peripheral governorates. The Neurosurgery Teaching Hospital in Bagdad was the neurosurgery center with the highest research output (n = 38).
    Conclusion: The number of publications per year has been showing a, relatively, promising trend since 2012. However, to promote sustained growth in academic productivity, a strategic plan that acknowledges the political, financial, and health-system-related challenges are urgently needed.
    Keywords:  Iraq; Neurosurgery; PubMed; Research papers
  16. Ann Palliat Med. 2021 Jun;10(6): 6367-6378
      BACKGROUND: Patients in the intensive care unit (ICU) often have serious infections, and anti-infection treatment is vital for these patients. Procalcitonin (PCT) is often used to identify bacterial infections and monitor the effectiveness of anti-infection treatments. This study aims to analyze the current research hotspots of the application of PCT in ICU patients, and to suggest future research directions.METHODS: The Science Citation Index Expanded (SCI-EXPANDED) database in the Web of Science Core Collection (WOSCC) was used as the data source to search literature from 1995 to February 6, 2021. The search strategy was subject term = procalcitonin AND Web of Science categories = Critical Care Medicine. Using CiteSpace software, literature on the application of PCT in ICU patients was analyzed.
    RESULTS: A total of 1,243 papers, including 665 (53.5%) original articles, 87 (7.0%) reviews, 93 (7.5%) letters, 297 (23.9%) conference abstracts, and 101 (8.1%) other articles, were analyzed. The citation frequency was 40,442, the h-index was 96, and the average number of citations per item was 32.54. Research was mainly from the United States, Germany, France, and Spain, amongst others. The research institutions were mainly Univ Basel Hosp, Univ Pittsburgh, and Univ Hosp Geneva. Authors including Schuetz P made more contributions. Critical Care Medicine, Intensive Care Medicine, and Critical Care were important journals in this field of research. The keywords with the highest frequency were PCT, sepsis, and infection, and the more central ones were PCT, inflammation, septic shock, and C-reactive protein. The keywords with the strongest citation bursts were PCT, cytokine, and serum.
    CONCLUSIONS: Papers are mainly published in critical care medical journals. The countries, institutions, and authors that carry out research are relatively limited. The current hot spots are still inflammation, infection, and shock, especially the management and prognosis prediction of critically ill patients.
    Keywords:  Procalcitonin (PCT); bibliometric analysis; intensive care
  17. Am J Emerg Med. 2021 Jun 22. pii: S0735-6757(21)00523-4. [Epub ahead of print]49 338-342
      BACKGROUND: Some studies have suggested gender disparities in both pay and academic promotion which may adversely affect salary and career progression for female physicians. The areas of research output, funding, and authorship have not been fully and systematically examined in the emergency medicine literature. We hypothesize that gender differences may exist in research output, impact, authorship, and funding.METHODS: We conducted a cross-sectional study examining all published articles in the top three emergency medicine journals as determined by Impact Factor between February 2015 and February 2018. We compared the authorship, number of citations of each article, funding, and h-index of each author by gender.
    RESULTS: Of the 10,118 authors representing 4166 original articles in our sample, 7562 (74.7%) were male and 2556 (25.3%) were female, with females underrepresented relative to the known proportion of female emergency medicine faculty. Males were proportionally more likely to be last authors (OR 1.65, 95% CI, 1.47-1.86) and less likely to be first authors than females (OR 0.85, 95% CI, 0.77-0.94). No difference in proportions of males and females in terms of being named as having funding was found (OR 1.02, 95% CI, 0.78-1.35). Males had higher h-indexes than females (5 vs. 3, p < .001) as well as a higher average number of citations (OR 1.068, 95% CI, 1.018-1.119).
    CONCLUSIONS: Males outnumber females in terms of numbers of publications, but also in number of citations, h-index, and last authorship. Future studies on physician gender disparities in emergency medicine need to account for these population differences.
    Keywords:  Academic medicine; Academic promotion; Faculty: Medicine; Gender equity; Journal article
  18. Chin Med. 2021 Jul 07. 16(1): 53
      BACKGROUND: Sterile inflammation is a key pathological process in stroke. Inflammasome activation has been implicated in various inflammatory diseases, including ischemic stroke and hemorrhagic stroke. Hence, targeting inflammasomes is a promising approach for the treatment of stroke.METHODS: We applied bibliometric methods and techniques. The Web of Science Core Collection was searched for studies indexed from database inception to November 26, 2020. We generated various visual maps to display publications, authors, sources, countries, and keywords.
    RESULTS: Our literature search yielded 427 publications related to inflammasomes involved in stroke, most of which consisted of original research articles and reviews. In particular, we found that there was a substantial increase in the number of relevant publications in 2018. Furthermore, most of the publications with the highest citation rates were published in 2014. Relatively, the field about inflammasomes in stroke developed rapidly in 2014 and 2018. Many institutions contributed to these publications, including those from China, the United States, and worldwide. We found that NLR family pyrin domain containing 3 (NLRP3) was the most studied, followed by NLRP1, NLRP2, and NLRC4 among the inflammasomes associated with stroke. Analysis of keywords suggested that the most studied mechanisms involved dysregulation of extracellular pH, efflux of Ca2+ ions, dysfunction of K+/Na+ ATPases, mitochondrial dysfunction, and damage to mitochondrial DNA.
    CONCLUSIONS: Given the potential diagnostic and therapeutic implications, the specific mechanisms of inflammasomes contributing to stroke warrant further investigation. We used bibliometric methods to objectively present the global trend of inflammasomes in stroke, and to provide important information for relevant researchers.
    Keywords:  Bibliometric; Global trends; Hemorrhagic stroke; Inflammasomes; Ischemic stroke; Mitochondrial dysfunction
  19. J Diabetes Metab Disord. 2021 Jun;20(1): 815-823
      Purpose: Research collaborations can help to increase scientific productivity. The purpose of the present study was to draw up the knowledge flow network of the Endocrinology and Metabolism Research Institute (EMRI) affiliated to Tehran University of Medical Sciences.Methods: The present study is a descriptive cross-sectional study on the publications of the EMRI. Web of Science Core collection databases were searched for the EMRI publications between 2002 to November 2019. Besides, publications were classified and visualized based on authorships (institutes and country of affiliation), and keywords (co-occurrence and trend). Scientometric methods including VOSviewer and HistCite were used for descriptive statistics and data analysis.
    Results: Total citations to the records were 47,528 and papers were published in 916 journals. The annual growth rate of publications and the citation was 14.2% and 18.9%, respectively. A total of 9466 authors from 136 countries collaborated in the publications. The co-authorship patterns showed that the average co-authorship and collaboration coefficient was 3.3 and 0.19.
    Conclusion: Knowledge flow between EMRI researchers with international collaborations, engagement with leading countries, and interdisciplinary collaborations have an increasing trend. To develop a full picture of co-authorship, using social network analysis indicators are suggested for future studies.
    Keywords:  Bibliometrics; Data visualization; EMRI; Knowledge discovery
  20. Environ Sci Pollut Res Int. 2021 Jul 05.
      The increasing issue of global warming has received tremendous attention from researchers around the world as researchers are actively publishing their findings related to environmental issues such as greenhouse gas emissions, carbon footprint, and air quality. In this bibliometric review, Scopus database was accessed to retrieve publications from 1971 to 2021, related to carbon footprint of buildings which is significantly associated with global warming and air quality. The results suggested that 41% of publications were published in close access journals requiring nominal subscription fee and/or institutional permissions for access to articles. Only 1% of publications were in press for publication, while 99% of them were online available. The trend of publications on carbon footprint has increased after 2002 and is also increasing in recent years as the topic is widely studied in many fields such as environmental sciences, engineering, materials sciences, earth and planetary sciences, chemical engineering, and energy. Approximately 97% publications were peer-reviewed journal articles. The authors, i.e., Aresta, M., Lin, T.P., and Persily, A.K., published highest number of publications among all on topic of carbon footprint. However, other authors, i.e., Cai, W., Chen, Z., Ma, M. Paik, I., and Pomponi, F., have published two publications each on carbon footprint of buildings. The funding for research on carbon footprint of buildings is mainly received from the National Institute of Standards and Technology, Lawrence Berkeley National Laboratory, and Tianjin University. However, the National Taiwan University, George Mason University, and Universita degi Studi di Bari hold 3% share in total number of publications on carbon footprint of buildings. As China and the USA are countries with highest share in global carbon footprint, both countries also have highest contribution in research on carbon footprint, followed by South Korea, the UK, Japan, Italy, Germany, Taiwan, etc. The study also concluded that, due to its wider readability and understanding, most of the publications were in the English language.
    Keywords:  Air quality; Bibliometric assessment; Bibliometric review; Carbon footprint; Environment; Research output; Scopus
  21. Medicine (Baltimore). 2021 Jul 09. 100(27): e26510
      BACKGROUND: Aristolochic acid nephropathy (AAN) is a type of drug-induced nephropathy that may result in acute kidney injury and is associated with a potentially progressive course of kidney fibrosis and upper tract urothelial carcinoma. Aristolochic acids (AAs) are a group of toxins commonly present in plants of the genera Aristolochia and Asarum, which are found worldwide. AAN still occurs in Asian and Balkan regions. The progressive lesions and mutational events initiated by AAs are irreversible, and no effective therapeutic regimen for AAN has been established. Furthermore, more people are at risk of this disease due to casual exposure to AAs. This study performed a scientometric analysis of global research literature focusing on AAN.METHODS: The Web of Science database was searched to identify all publications pertaining to "aristolochic acid nephropathy" or "Balkan endemic nephropathy" using these terms as key words to search the literature from 1971 to 2019. The collected data included the document type, author, journal, publication year, citation reports, and country of publication, and were analyzed using the VOSviewer software.
    RESULTS: A total of 1251 records were initially obtained. Publication types, including "meeting abstract," "letter," "editorial material," and "proceedings paper" were excluded, which left 1083 publications comprising 923 articles and 160 reviews. English was the predominant language of the publications. China had the most number of articles published with 217 (20.0%), followed by the USA with 186 articles (17.2%), and Germany with 138 articles (12.7%). Kidney International, Food and Chemical Toxicology, and Toxins were the 3 most active journals in publishing articles related to AAN. The total number of citations received by all publications was 39,970, with an average of 36.91 citations per article (range: 0-1769). The literature mainly focused on apoptosis, oxidative stress, and inflammation in AAN.
    CONCLUSION: This study indicated that AAN is a significant topic in nephrology research, as shown by the large number of publications. The literature has mainly focused on the mechanisms of AA-induced nephropathy.
  22. Front Pharmacol. 2021 ;12 687757
      Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system. Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field. Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16). Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, "quinolinic acid." All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were "kynurenine pathway," "psychoneuroimmunology," "indoleamine 2,3-dioxygenase," and "proinflammatory cytokines," and the most recent focus was "gut-brain axis," thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field's research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics "Alzheimer's disease," "prefrontal cortex," and "acid," were research frontiers. Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field's hotspots and frontiers, thus facilitating future research.
    Keywords:  bibliometric analysis; bipolar disorder; depression; gut microbiota; immune system; kynurenine pathway; microbiota-gut-brain axis; mood disorders
  23. Cont Lens Anterior Eye. 2021 Aug;pii: S1367-0484(21)00058-8. [Epub ahead of print]44(4): 101447
    Keywords:  Bibliometric analysis; Scleral contact lens; h-index
  24. Environ Sci Pollut Res Int. 2021 Jul 08.
      The demand together with the urgency of phosphogypsum (PG) treatment will pose significant challenges for many countries. This research aims to explore the research progress of PG, including basic status, cooperation situation, research fields, and development trends, based on the Web of Science database through bibliometric analysis of publications (articles and patents) from 1990 to 2020. The results show that academic research on PG originated early, but the number of patents grew quickly. China is a global leader in terms of the number of publications and plays a significant role in international cooperation. The knowledge of PG has remained concentrated in the fields of natural radioactivity, cement paste backfilling, soil, crystal morphology, and synthetic gas. However, academic hotspots focus on the microstructure of chemical processes and various environmental impacts; patents and hot technologies are based on the production of refractory materials, ceramics, surface materials, cement mortar, and composite materials. The academic frontiers of PG will be centered on exploiting the methods of recovering rare earth elements from PG, the conditions of ion solidification/stabilization in PG, the impact of reaction conditions on product quality, and the reaction mechanism at the micro-level. The frontiers of patents need to focus on the improvement of manufacturing equipment, new wall materials, and chemically modified polymer materials. Envisaging the number of articles and patents to be published in the future, architectural research has a large room for improvement. This paper conducts an in-depth analysis of PG and provides information on the technological development prospects and opportunities, which is helpful for researchers engaged in PG management.
    Keywords:  Bibliometric; CiteSpace; Knowledge map; Phosphogypsum; S-curve; Technology life cycle
  25. Learn Publ. 2021 Jun 01.
      The impact of COVID-19 has underlined the need for reliable information to guide clinical practice and policy. This urgency has to be balanced against disruption to journal handling capacity and the continued need to ensure scientific rigour. We examined the reporting quality of highly disseminated COVID-19 research papers using a bibliometric analysis examining reporting quality and risk of bias (RoB) amongst 250 top scoring Altmetric Attention Score (AAS) COVID-19 research papers between January and April 2020. Method-specific RoB tools were used to assess quality. After exclusions, 84 studies from 44 journals were included. Forty-three (51%) were case series/studies, and only one was an randomized controlled trial. Most authors were from institutions based in China (n = 44, 52%). The median AAS and impact factor was 2015 (interquartile range [IQR] 1,105-4,051.5) and 12.8 (IQR 5-44.2) respectively. Nine studies (11%) utilized a formal reporting framework, 62 (74%) included a funding statement, and 41 (49%) were at high RoB. This review of the most widely disseminated COVID-19 studies highlights a preponderance of low-quality case series with few research papers adhering to good standards of reporting. It emphasizes the need for cautious interpretation of research and the increasingly vital responsibility that journals have in ensuring high-quality publications.
    Keywords:  COVID‐19; altmetrics; coronavirus Infections; pandemics; publication impact; quality
  26. Phys Med. 2021 Jul 02. pii: S1120-1797(21)00233-7. [Epub ahead of print]88 111-116
      PURPOSE: Within the Italian Association of Medical Physics and Health Physics (AIFM) working group "FutuRuS" we carried out a survey regarding the number of the peer-reviewed articles by AIFM members.METHODS: We surveyed papers published in the years 2015-2019. Data extracted from Scopus included information regarding authors, title, journal, impact factor (IF), leading or standard authorship by AIFM members, keywords, type of collaboration (monocentric/multicentric/international), area of interest [radiation oncology (RO), radiology (RAD), nuclear medicine (NM), radioprotection (RP) and professional issue (PI)] and topics.
    RESULTS: We found 1210 papers published in peer-reviewed journals: 48%, 22%, 16%, 6%, 2 and 6% in RO, RAD, NM, RP, PI and other topics, respectively. Forty-seven percent of the papers involved monocentric teams, 31% multicentric and 22% international collaborations. Leading authorship of AIFM members was in 56% of papers, with a corresponding IF equal to 52% of the total IF (3342, IFmean = 2.8, IFmax = 35.4). The most represented journal was Physica Medica, with 15% of papers, while a relevant fraction of IF (54%) appeared in clinically oriented journals. The number of papers increased significantly between 2015 and 2016 and remained almost constant in 2017-2019.
    CONCLUSIONS: This survey led to the first quantitative assessment of the number and theme distribution of peer-reviewed scientific articles contributed by AIFM members. It constitutes a ground basis to support future AIFM strategies and promote working groups on scientific activity of medical physicists, and to build the basis for rational comparison with other countries, first of all within Europe.
    Keywords:  Medical physicists; Nuclear medicine; Radiation oncology; Radiology; Scientific publications
  27. Curr Psychol. 2021 Jun 30. 1-21
      Pro-environmental behavior (PEB) has always been a hot topic in academic and practical, and it is highly necessary to explore the research progress and development trend of PEB. Based on 1038 relevant literatures published and the Web of Science core database, this paper used citation analysis, co-word analysis and cluster analysis methods to systematically analyze the dynamic evolution process of PEB's research topics, knowledge base and subject areas. The results show that PEB research is currently in a period of rapid growth. And PEB research presents typical multidisciplinary characteristics, mainly focuses on Psychology-Education-Social, Economics-Economic-Political, Environmental-Toxicology-Nutrition and other disciplines. Then, this study also finds that the PEB research hotspots mainly concentrated in seven directions such as "Environmental cognition, emotion and motivation process", etc., which can be further classified into three horizontal levels and three vertical levels. This study will provide valuable theoretical and practical reference for the future research of PEB.
    Keywords:  Basic knowledge; Bibliometric methods; Cluster analysis; Co-occurrence analysis; Pro-environmental behavior
  28. J Neurosurg Anesthesiol. 2021 Jul 08.
      INTRODUCTION: There is limited literature on the representation of women in leading roles in neuroanesthesiology and neurocritical care academia. We aimed to determine the representation of women as first and corresponding authors in articles published in 3 dedicated journals of neuroanesthesiology and neurocritical care during last 5 years.METHODS: Articles published in the Journal of Neurosurgical Anesthesiology, Neurocritical Care, and Journal of Neuroanaesthesiology and Critical Care between July 1, 2015 and June 30, 2020 were included in this study. The primary outcome was the proportion of women first authors, and secondary outcomes were the percentage of women corresponding authors, and representation of women as first and corresponding author by article type and country of affiliation.
    RESULTS: Of the 1164 articles included in the study, 403 (34.6%) had a woman first author. Women first authorship was highest for Special Articles (5/11; 45.5%), Clinical Reports (44/113; 38.9%) and Narrative Review Articles (58/151; 38.4%) and lowest for Original Research Articles (198/597; 33.2%). Women accounted for 29.6% (344/1164) of corresponding authors across all article types. Overall, the United States and India had the highest representation of women first authors (159/403; 39.0% and 107/344; 31.0%, respectively), and India also had highest proportion of women corresponding authors (107/272; 39.3%).
    CONCLUSIONS: Women were underrepresented compared with men as first author of articles published in 3 dedicated neuroanesthesiology and neurocritical care journals over the last 5 years. Women had the lowest representation as authors of Original Research Articles.
  29. Decis Sci. 2020 May 26.
      This review examines supply chain risk publications across nine prestigious management, operations, and supply chain journals with respect to exploring trends and emerging topics. Using a refined set of keywords, we extract and filter the most relevant supply chain risk management (SCRM) articles from Scopus between 2001 and 2019. Unlike previous reviews of the SCRM literature, our methodology utilizes both bibliometric and co-citation analyses of publications in selective management and operations and supply chain management journals. In addition to analyzing the current state of the SCRM literature via bibliometric analysis, we delve deeply into the clusters of literature informing SCRM studies through a co-citation analysis. By conducting a text analysis on these clusters, we identify the main themes and provide insights regarding article relevance, theoretical frameworks, and methodologies for each cluster. In addition, we categorize the themes within each cluster into three main groups of Matured, Developing, and Emerging. Based on the identified Emerging categories, we provide detailed discussions on the promising avenues for research and practice in three main areas of Sustainable SCRM, Behavioral SCRM, and nascent methodologies and theories in SCRM studies. Finally, we dedicate a section in our review to discussing the direction of SCRM research during and after the COVID-19 era. This article is protected by copyright. All rights reserved.
    Keywords:  co‐citation analysis; supply chain resilience; supply chain risk; systematic review
  30. Global Health. 2021 Jul 03. 17(1): 74
      BACKGROUND: This paper has reviewed the international research on the terms "climate change" and "human migration" from 1999 to 2019. To this end, a bibliometric and a cluster analysis by fractional accounting have been carried out using two of the most important databases: Web of Science (WoS) and Scopus. The research found and studied 140 documents from WoS Core Collection and 193 from Scopus.RESULTS: The results show a continual increase in the number of articles published and citations received during the whole period studied. The U.S., U.K., Germany and China have been shown to be the most productive countries and there is a predominance of North American organizations supporting and fostering research on these topics.
    CONCLUSIONS: The main contribution of this article is the analysis of new tendencies. The trend shows a transition from concepts such as vulnerability, climate change, land degradation, refugees and security to others such as concepts such as international migration, climate justice, sustainability, human rights and disaster risk reduction. Future research in this field should address the comparison of results from research focused on human beings to a focus on other living beings.
    Keywords:  Bibliometrics; Climate change; Migration; Sustainability
  31. Environ Sci Pollut Res Int. 2021 Jul 07.
      Landfilling is one of the most prevalent waste management strategies on a global scale. However, one major drawback of landfills is the production of highly contaminated leachate which can harm ecosystems and pollute water resources which municipalities depend on. Various treatment options have been explored for treating leachate throughout the years. This paper aims to investigate landfill leachate treatment studies through bibliometric and visual analysis of articles collected from the Scopus database from 1975 to 2019. The results show that more than one thousand papers have been published in 159 journals. Nearly 3000 authors have published on the topic, most commonly from China, the USA, Malaysia, and Brazil. The keywords co-occurrence network led to the formation of 5 topical clusters, after which they were closely examined and titled "oxidation processes," "nitrogen removal processes," "constructed wetlands/coagulation," "adsorption," and "membrane-based processes" based on their contents. Finally, the overlay network was used to discern the hottest research trends. The results showed that advanced coagulation-based processes (such as peroxicoagulation) and studies focusing on improving membrane-based processes through reduction of membrane fouling are focal points which will be trending into the future.
    Keywords:  Bibliometrics; Municipal solid waste; Scientometrics; VOSviewer; Waste management
  32. Front Public Health. 2021 ;9 666669
      Background: Studying the scientific literature about COVID-19 and Italy, one of the first countries to be hit by the pandemic, allows an investigation into how knowledge develops during a public health emergency. Methods: A systematic review of the literature was conducted to identify articles published on the topic between January and April 2020. Articles were classified according to type of study. Co-occurrence of terms, and geographic and temporal trends were analyzed. Results: Of the 238 articles included in the systematic review, the majority (37%) focused on hospital and clinical management of COVID-19, while 23.9% were commentaries. Epidemiological studies constituted 45.5% of the articles published by authors with non-Italian affiliations. Conclusion: The scientific articles on COVID-19 in Italy were varied in type of study, though with limited international impact. The lockdown and the pressure placed on hospitals during the first wave of the pandemic mainly resulted in publications on disease management and commentaries.
    Keywords:  COVID-19; Italy; bibliometric analysis; coronavirus; public health; systematic review
  33. Appl Netw Sci. 2021 ;6(1): 48
      Delayed recognition in which innovative discoveries are re-evaluated after a long period has significant implications for scientific progress. The quantitative method to detect delayed recognition is described as the pair of Sleeping Beauty (SB) and its Prince (PR), where SB refers to citation bursts and its PR triggers SB's awakeness calculated based on their citation history. This research provides the methods to extract valid and large SB-PR pairs from a comprehensive Scopus dataset and analyses how PR discovers SB. We prove that the proposed method can extract long-sleep and large-scale SB and its PR best covers the previous multi-disciplinary pairs, which enables to observe delayed recognition. Besides, we show that the high-impact SB-PR pairs extracted by the proposed method are more likely to be located in the same field. This indicates that a hidden SB that your research can awaken may exist closer than you think. On the other hand, although SB-PR pairs are fat-tailed in Beauty Coefficient and more likely to integrate separate fields compared to ordinary citations, it is not possible to predict which citation leads to awake SB using the rarity of citation. There is no easy way to limit the areas where SB-PR pairs occur or detect it early, suggesting that researchers and administrators need to focus on a variety of areas. This research provides comprehensive knowledge about the development of scientific findings that will be evaluated over time.
    Keywords:  Bibliometrics; Citation network; Delayed recognition; Interdisciplinary fusion; Prince; Production of knowledge; Sleeping beauty
  34. Aesthet Surg J Open Forum. 2021 Sep;3(3): ojab020
      Background: Breast augmentation is one of the most commonly performed cosmetic surgeries worldwide. Therefore, it is imperative to have evidence with high methodological quality to guide clinical decision making.Objectives: To evaluate the methodological quality of the systematic reviews (SRs) focused on breast augmentation.
    Methods: A comprehensive search of MEDLINE, Embase, and the Cochrane Library of Systematic Reviews was performed. SRs that have a particular focus on breast augmentation and were published in the top 15 plastic and reconstructive surgery journals were included. Quality assessment was performed using a measurement tool to assess systematic reviews (AMSTAR). Study characteristics were extracted including journal and impact factor, year of publication, country affiliation of the corresponding author, reporting adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, number of citations, and number of studies included.
    Results: Among the 22 studies included for analysis, the mean AMSTAR score was moderate (5.55), with no SR achieving good quality (AMSTAR score of ≥9). There were no significant associations between AMSTAR score and journal impact factor, number of citations, year of publication, or number of included studies. Studies that reported adherence to PRISMA guidelines on average scored higher on the AMSTAR tool (P = 0.03).
    Conclusions: The methodological quality of reviews about breast augmentation was found to be moderate, with no significant increase in studies or quality over time. Adherence to PRISMA guidelines and increased appraisal of SRs about breast augmentation using methodological assessment tools would further strengthen methodological quality and confidence in study findings.
  35. Int Immunopharmacol. 2021 Jul 01. pii: S1567-5769(21)00555-5. [Epub ahead of print]98 107919
      Apolipoprotein E (apoE, protein; APOE, gene) involves in cholesterol recycling and redistribution by mediating lipoprotein pathways unique to central nervous system (CNS), which is a potential therapeutic target for diseases. We visually analyzed the research hotspots of APOE related to CNS in this work, by scientometric analysis from the Web of Science Core Collection (WOSCC) database over the past two decades. A total of 25,719 references of "APOE" and 836 references of "APOE in CNS" were retrieved from the WOSCC on October 26, 2020, and then VOSviewer 1.6.15, Citespace 5.7.R2 were used for visual analysis. Over the last two decades, the research on the field of APOE in CNS is not faddish. Although many funds, organizations, and scholars were affiliated in this field, organizations and scholars, especially the top teams in this field, still lacked close cooperation with other teams around the world. Few articles with high citations had been published in the last decade, but recent studies still lacked scale and breakthrough, and the keywords associated with APOE appeared more outdated. However, the current researches have not fully elucidated the crosstalk between APOE and neuroinflammation in CNS, some new ideas may rekindle the research enthusiasm of scholars. Although the field of APOE in CNS appeared more outdated. Based on keyword analysis, we hypothesized new ideas for further investigation of neuroinflammation would light the interest of APOE in CNS for the scholars. The crosstalk between ApoE and inflammasome may be the focus of future researches. How APOE modulates the time course or intensity of the inflammasome activation, inflammatory response (proinflammatory or anti-inflammatory), and pathological process of CNS disease deserves future attention in both basic and clinical studies. More apoE/APOE-targeted pharmacological interventions will be available for preclinical experiments and clinical trials and bring hope for patients with CNS diseases.
    Keywords:  Central nervous system; Inflammasome; Neuroinflammation; Scientometric analysis; apolipoprotein E
  36. Account Res. 2021 Jul 03.
      In its current mode of identification of scientific publications, the digital object identifier (DOI) is not more than a web linking of published material to their publishing sources. When a given DOI is searched in the DOI website (, we are redirected to the publishing websites, if the material is available, or an error message (Not Found) will appear if the DOI-associated content is not available or has moved to a new location. To bestow a worthwhile value to DOI assignations, I suggest the establishment of a unique persistent DOI database (for e.g., as a DOI hub, DOI library, or DOI indexer) in which all the DOI assigned by publishers and journals will be listed in one and same place with basics bibliographic metadata and complete citation information, including the DOI link itself, authors' names, manuscripts' titles, publishing source, date of publication, and ideally abstracts if available. As a result, when a DOI is searched in the DOI hub, full bibliographic information should be retrievable regardless of its status in the publishing source. Basic indexation information and metadata associated with published articles will be always accessible and findable independently from the publishing sources. A unique, general and long-term preserved DOI hub will make it easy to search, find and cite scientific literature from the various scientific fields even if a journal or publisher ceases its publishing activity.
    Keywords:  bibliography database; digital object identifier; doi; doi hub; doi indexer; doi library; persistent archive; science archive; science hub; science indexation
  37. Se Pu. 2021 Jun;39(6): 559-566
      This paper reviews the developments in capillary electrophoresis (CE) in 2020. A total of 222 research papers related to CE technology published in 2020 were retrieved from the ISI Web of Science. These papers were selected by using the keywords "capillary electrophoresis-mass spectrometry", "capillary isoelectric focusing", "micellar electrokinetic chromatography", or "capillary electrophoresis" as search conditions. A further 37 research papers related to CE technology were found in Chinese journals: Chinese Journal of Analytical Chemistry and Chinese Journal of Chromatography. The 38 papers published in 13 different journals with an impact factor (IF)≥5.0 are individually discussed. In particular, the journal Analytical Chemistry (IF=6.8) was found to have nine relevant articles, eight of which were related to CE-MS technology and its application, while Food Chemistry (IF=6.3) published five articles with four papers based on micellar electrokinetic chromatography (MEKC) and its combined technology. This demonstrated that MEKC can simultaneously separate negatively charged, positively charged, and neutral particles, in addition to featuring the advantage of combining different detector applications for the analysis of target matter in a complex matrix. In Analytica Chimica Acta (IF=6.0), five articles were collected, which mainly focused on new applications of CE-MS and multimode CE research. In Talanta (IF=5.3), 10 articles were collected, which focused on new methods and applications of CE and CE-MS. The remaining nine articles, i. e., seven experimental articles, one review article, and one introduction of scientific research achievements, were published in various other high-impact journals. At the same time, 184 articles were found in 89 journals with IF<5.0. In particular, the Journal of Chromatography A (IF=4.1) and Electrophoresis (IF=3.1) contained intensive reports for CE: 16 and 24 publications in relevant areas. The representative contents of 40 articles published in two journals were introduced comprehensively in this review, including new materials and new applications of MEKC, as well as new applications of CE-MS and CE. An overview of the work in the 37 articles collected from Chinese journals included "Aptamer Special Issue" published by Chinese Journal of Analytical Chemistry and two CE technical special issues published by Chinese Journal of Chromatography. In the "Aptamer Special Issue", Qu Feng's research group from Beijing Institute of Technology reported five works on aptamers based on CE, while the contents of Chinese Journal of Chromatography include new applications of CE and new materials in capillary tubes. In summary, new methods and applications of capillary electrophoresis-mass spectrometry (CE-MS) were the prominent development trend in CE technology in the year 2020, with the main focus being on the combination of CE-MS with electrochemical detection, solid-phase extraction, and various capillary electrophoresis modes. The number of reports related to the CE-MS interface has decreased compared to that in previous years. Conventional CE technology is mainly focused on the applications of MEKC in the analysis and concentration of complex samples, especially for the analysis of complex matrix samples such as food and drugs. In addition, the scientific research achievements of Chinese experts and scholars in CE-related fields cover the application of CE in life sciences, clinical medicine, pharmaceutical research and development, environmental science, natural products, food analysis, etc., representing the level and current status of the application of CE research in China.
    Keywords:  2020; annual review; capillary electrophoresis (CE)
  38. Account Res. 2021 Jul 06.
      Previous research has found authors of retracted publications responsible for the vast majority of retractions. Although considerable research attention has been given to reasons for retraction, few studies have examined author-related reasons from a cross-disciplinary and a severity-based perspective. Drawing on data from the Web of Science Core Collection, this study examined 6,861 retraction notices published before 2020, in which authors were identified as the sole entities responsible for retraction. A close scrutiny identified 17 distinct reasons for retraction, with the three most frequent (i.e., plagiarism/self-plagiarism, unreliable data/findings, and data fabrication/falsification) accounting for 78.87% of the retraction notices. Based on the severity of the culpable actions involved, the 17 reasons were grouped into five categories: blatant misconduct (disclosed in 61.08% of the retraction notices), inappropriate conduct (18.18%), questionable conduct (0.95%), honest error (4.62%), and uncategorizable conduct (30.52%). Retraction notices in hard disciplines (i.e., natural sciences) were found more likely than those in soft disciplines (i.e., social sciences, arts, and the humanities) to disclose authorship issues, unreliable data/findings, uncategorizable conduct, and inappropriate conduct. Retraction notices in soft disciplines were more likely than those in hard disciplines to disclose unspecified misconduct and blatant misconduct.
    Keywords:  Web of Science; academic integrity; disciplinary variation; misconduct; reasons for retraction; research ethics; severity of reasons for retraction
  39. Obes Facts. 2021 Jul 08. 1-15
      INTRODUCTION: Obesity is classified as a global epidemic and judged to be the greatest public health threat in Western countries. The tremendously increasing prevalence rates in children lead to morbidity and mortality in adults. In many countries, prevalence has doubled since the 1980s. Other countries show a continuous increase or stagnate at a very high level. Given these regional differences, this study aims to draw a global world map of childhood obesity research, including regional epidemiological characteristics, to comprehensively assess research influences and needs.METHODS: In addition to established bibliometric parameters, this study uses epidemiological data to interpret metadata on childhood obesity research from the Web of Science in combination with state-of-the-art visualization methods, such as density equalizing map projections.
    RESULTS: It was not until the 1990s that belated recognition of the dangerous effects of childhood obesity led to an increase in the number of publications worldwide. In addition, our findings show that countries' study output does not correlate with epidemiologic rates of childhood obesity. In contrast, the primary driver of the research efforts on childhood obesity appears to be largely driven government funding structures.
    DISCUSSION/CONCLUSION: The geographical differences in the epidemiological background of childhood obesity complicate the implementation of transnational research projects and cross-border prevention programs. Effective realization requires a sound scientific basis, which is facilitated by globally valid approaches. Hence, there is a need for information exchange between researchers, policy makers, and private initiatives worldwide.
    Keywords:  Child adiposity; Global health; Prevalence; Public health; Publication output
  40. J Neurooncol. 2021 Jul 07.
      INTRODUCTION: Neurosurgeons represent 0.5% of all physicians and currently face a high burden of disease. Physician-scientists are essential to advance the mission of National Academies of Science (NAS) and National Institutes of Health (NIH) through discovery and bench to bedside translation. We investigated trends in NIH neurosurgeon-scientist funding over time as an indicator of physician-scientist workforce training.METHODS: We used NIH Research Portfolio Online Reporting Tools (RePORTER) to extract grants to neurosurgery departments and neurosurgeons from 1993 to 2017. Manual extraction of each individual grant awardee was conducted.
    RESULTS: After adjusting for U.S. inflation (base year: 1993), NIH funding to neurosurgery departments increased yearly (P < 0.00001). However, neurosurgeon-scientists received significantly less NIH funding compared to scientists (including basic scientists and research only neurosurgeons) (P = 0.09). The ratio of neurosurgeon-scientists to scientists receiving grants was significantly reduced (P = 0.002). Interestingly, the percentage of oncology-related neurosurgery grants significantly increased throughout the study period (P = 0.002). The average number of grants per neurosurgeon-scientists showed an upward trend (P < 0.001); however, the average number of grants for early-career neurosurgeon-scientists, showed a significant downward trend (P = 0.05).
    CONCLUSION: Over the past 23 years, despite the overall increasing trends in the number of NIH grants awarded to neurosurgery departments overall, the proportion of neurosurgeon-scientists that were awarded NIH grants compared to scientists demonstrates a declining trend. This observed shift is disproportionate in the number of NIH grants awarded to senior level compared to early-career neurosurgeon-scientists, with more funding allocated towards neurosurgical-oncology-related grants.
    Keywords:  Clinician-scientist; Funding; National Institutional of Health (NIH) funding to neuro-surgery; Neurosurgeon-Scientist; Research; Training
  41. J Med Internet Res. 2021 Jul 05.
      BACKGROUND: Glaucoma leads to irreversible blindness. Globally, it is the second most common retinal disease that leads to blindness, slightly less common than cataracts. Therefore, there is a great need to avoid the silent growth of this disease using recently developed generative adversarial networks (GANs).OBJECTIVE: This paper aims to introduce generative adversarial network technology for the diagnosis of eye disorders, particularly glaucoma. This paper illustrates deep adversarial learning as a potential diagnostic tool and the challenges involved in its implementation. This study describes and analyzes many of the pitfalls and problems that researchers will need to overcome to implement this kind of technology.
    METHODS: To organize this review comprehensively, articles and reviews were collected using the following keywords: ("Glaucoma", "optic disc", "blood vessels") and ("receptive field", "loss function", "GAN", "Generative Adversarial Network", "Deep learning", "CNN", "convolutional neural network" OR encoder). The records were identified from five highly reputed databases: IEEE Xplore, Web of Science, Scopus, Science Direct, and PubMed. These libraries broadly cover the technical and medical literature. Among the last five years of publications, only papers within the specified duration were included because the target GAN technique was invented in 2014 by Goodfellow and the publishing date of the collected papers was not earlier than 2016. Duplicate records were removed, and irrelevant titles and abstracts were excluded. In addition, we excluded papers that used optical coherence tomography (OCT) and visual field images, except for those with two-dimensional images. A large-scale systematic analysis was performed, and then a summarized taxonomy was generated. Furthermore, the results of the collected articles were summarized and added to multimedia appendix 1 and a visual representation of the results on a T-shaped matrix diagram. This study was conducted between March 2020 and November 2020.
    RESULTS: We found 59 articles after conducting a comprehensive survey of the literature. Among the 59 articles, 29 present actual attempts to synthesize images and provide accurate segmentation/classification using single/multiple landmarks or share certain experiences. Twenty-nine journal articles discuss recent advances in generative adversarial networks, practical experiments, and analytical studies of retinal disease.
    CONCLUSIONS: Recent deep learning techniques, namely, generative adversarial networks, have shown encouraging retinal disease detection performance. Although this methodology involves an extensive computing budget and optimization process, it saturates the greedy nature of deep learning techniques by synthesizing images and solves major medical issues. This paper contributes to this research field by offering a thorough analysis of existing works, highlighting current limitations, and suggesting alternatives to support other researchers and participants in further improving and strengthening future work. Finally, new directions for this research have been identified.
  42. Cardiol Young. 2021 Jul 08. 1-2
    Keywords:  Impact; paediatric cardiology; research
  43. Med Anthropol. 2021 Jul 08. 1-18
      Chagas is the most important endemic disease in Latin America. It was progressively constructed as a relevant public issue, starting as a medical problem, focusing later on housing conditions, poverty, or vector agents. In recent decades, research has mainly focused on the parasite's biological characterization. In the meanwhile, both Chagas disease and knowledge about it spread out geographically. We analyze the worldwide scientific production on Chagas, showing that countries' research strategies depend on two main factors: endemicity and research traditions. This approach complements previous studies, allowing us to better understand the construction of Chagas disease as a social and scientific problem.
    Keywords:  Chagas disease; bibliometric; health; knowledge use; neglected diseases
  44. BMC Med Res Methodol. 2021 Jul 08. 21(1): 142
      BACKGROUND: Standard practice for conducting systematic reviews (SRs) is time consuming and involves the study team screening hundreds or thousands of citations. As the volume of medical literature grows, the citation set sizes and corresponding screening efforts increase. While larger team size and alternate screening methods have the potential to reduce workload and decrease SR completion times, it is unknown whether investigators adapt team size or methods in response to citation set sizes. Using a cross-sectional design, we sought to understand how citation set size impacts (1) the total number of authors or individuals contributing to screening and (2) screening methods.METHODS: MEDLINE was searched in April 2019 for SRs on any health topic. A total of 1880 unique publications were identified and sorted into five citation set size categories (after deduplication): < 1,000, 1,001-2,500, 2,501-5,000, 5,001-10,000, and > 10,000. A random sample of 259 SRs were selected (~ 50 per category) for data extraction and analysis.
    RESULTS: With the exception of the pairwise t test comparing the under 1000 and over 10,000 categories (median 5 vs. 6, p = 0.049) no statistically significant relationship was evident between author number and citation set size. While visual inspection was suggestive, statistical testing did not consistently identify a relationship between citation set size and number of screeners (title-abstract, full text) or data extractors. However, logistic regression identified investigators were significantly more likely to deviate from gold-standard screening methods (i.e. independent duplicate screening) with larger citation sets. For every doubling of citation size, the odds of using gold-standard screening decreased by 15 and 20% at title-abstract and full text review, respectively. Finally, few SRs reported using crowdsourcing (n = 2) or computer-assisted screening (n = 1).
    CONCLUSIONS: Large citation set sizes present a challenge to SR teams, especially when faced with time-sensitive health policy questions. Our study suggests that with increasing citation set size, authors are less likely to adhere to gold-standard screening methods. It is possible that adjunct screening methods, such as crowdsourcing (large team) and computer-assisted technologies, may provide a viable solution for authors to complete their SRs in a timely manner.
    Keywords:  Crowdsourcing; Machine learning; Scoping reviews; Systematic reviews