bims-evares Biomed News
on Evaluation of research
Issue of 2020‒11‒29
forty papers selected by
Thomas Krichel
Open Library Society


  1. Arthroplast Today. 2020 Dec;6(4): 931-940
    Yakkanti R, Greif DN, Wilhelm J, Allegra PR, Yakkanti R, Hernandez VH.
      Background: Unicondylar knee arthroplasty (UKA) is an accepted treatment option for unicompartmental femorotibial degeneration and is gaining in popularity. The goal of this review is to evaluate the top 50 most cited articles pertaining to UKA to better help surgeons understand the trends, identify influential articles, and navigate this body of literature more effectively.Methods: The Institute for Scientific Information Web of Knowledge database was used to identify all articles related to UKA. The initial screening was based on the number of citations for each article. The list was then refined to include only peer-reviewed original articles, review articles, or editorials. Data were extracted from the articles to rank the articles in the descending order from the most citations to the least.
    Results: Initial search yielded 1844 articles. Fifty were identified to match the study criteria. The highest ranked article was cited a total of 463 times, whereas the lowest ranked article was cited 101 times. The average total number of citations per publication was 162. The earliest article on the list was published in 1978. The majority of publications assessed long-term outcomes of UKA (n = 6, 52%). The majority of articles were graded a level of evidence of III (n = 21 42%), whereas only 3 articles were graded a level I.
    Conclusions: This review provides a quantitative analysis of the most-cited literature pertaining to UKA, which has a paucity of level I studies.
    Keywords:  Bibliometric; Unicondylar; Unicondylar arthroplasty
    DOI:  https://doi.org/10.1016/j.artd.2020.09.012
  2. Rev Esp Enferm Dig. 2020 Nov 24.
    Bojo Canales C, Perdiguero-Gil E.
      The goal of this work was to show, through a case study involving the Revista Española de Enfermedades Digestivas (REED), the potentialities offered by the SciELO network indicators for the management of scientific journals. SciELO offers indicators (production, collaboration, use) that complement the conventional analysis indices used for written science. In order to illustrate their uses a bibliometric, descriptive study was undertaken of the scientific production published by the above-mentioned journal over the period 2004-2018. In the last 5 years REED received 3,976,685 visits. The second issue of 2007 is the most widely accessed sample to this day. A total of 173 issues, 1,810 citable articles, 2,927 documents, and 47,645 references have been published, with the number of published papers increasing by 268%. Clinical case reports make up the highest number. REED received a total of 3,613 citations, with 60% of self-citation. Of all published documents, 42% originate in Spain and 10.6% abroad. Group authorship predominates over individual authors, with a median and mode of 5. The cooperation index was 5.12. The highest impact factor was 0.492 in 2008. The journals most commonly cited by REED are all foreign publications in the Gastroenterology and Hepatology section of the Science Citation Index.
    DOI:  https://doi.org/10.17235/reed.2020.7169/2020
  3. Geriatr Orthop Surg Rehabil. 2020 ;11 2151459320973196
    Wang SQ, Wang JX, Zhang C, Sun FH, Xie YJ, Jiang W, Ou X, Miyamoto A, Wang L.
      Background: Osteoarthritis is a degenerative disease that commonly occurs in middle-aged and elderly people. High-quality articles in the field of osteoarthritis rehabilitation have not been studied in detail.Objective: To identify and conduct a qualitative and quantitative analysis of the 50 most-cited articles on osteoarthritis rehabilitation and provide valuable scientific information for researchers.
    Methods: Fifty articles related to the rehabilitation of individuals with osteoarthritis were retrieved from the Web of Science Core Collection. Basic information, such as the authors, title, number of citations, year of publication, journal, country/territory, and research type, was extracted. CiteSpace was used to visualize the keywords.
    Results: The average number of citations per article was 244.54. The top 50 articles were published in 27 journals and published by 262 authors. Most of the top 50 articles were published in the United States. The top 50 articles included 23 randomized controlled trials, 21 cohort studies, 2 case series, and 4 expert opinion articles. The most commonly studied topics in osteoarthritis rehabilitation included rehabilitation for pain, gait abnormalities, muscle strength deficiencies, and other functional impairments caused by osteoarthritis in elderly people.
    Conclusions: The top articles in the field of osteoarthritis rehabilitation have a high level of evidence. Collaboration between authors was high for highly-cited articles. Moreover, the eminent articles can provide important information for the education of doctors and therapists specializing in osteoarthritis rehabilitation.
    Keywords:  bibliometrics; journal article; osteoarthritis; physical therapy modalities; rehabilitation
    DOI:  https://doi.org/10.1177/2151459320973196
  4. Periodontol 2000. 2020 Nov 23.
    Ahmad P, Slots J.
      This bibliometric study assessed periodontal/implant articles that were part of the five most-cited dental articles in each of the years 2005-2019. Periodontal/implant articles made up one to four articles in each of 14 years and totaled 40% of the yearly five most-cited dental articles. The three core periodontal journals (Journal of Clinical Periodontology, Journal of Periodontology, and Periodontology 2000) increased ~50%-100% in Journal Impact Factor from 2005 to 2015 and were among the 10 most-cited dental journals in the 2015-2019 period. The Journal of Clinical Periodontology and Periodontology 2000 were in several years assigned the highest Journal Impact Factor in dentistry. In summary, periodontal journals continue to publish high-impact articles that are relevant for both oral health care and medicine.
    DOI:  https://doi.org/10.1111/prd.12376
  5. Insights Imaging. 2020 Nov 23. 11(1): 123
    Yaxley KL, To MS.
      PURPOSE: To identify the 100 top-cited meta-analyses of diagnostic accuracy studies published in radiology, medical imaging and nuclear medicine journals.METHODS: A PubMed search with pre-defined criteria was performed. The 100 top-cited articles meta-analyses were retrieved, using a custom Python script and the Scopus Application Programming Interface (Elsevier). Publication, citation and affiliation details were extracted from each meta-analysis. No formal statistical analysis was performed.
    RESULTS: The top meta-analysis was cited 394 times, the 100th meta-analysis 38 times. The USA was the top country represented in the papers (33 meta-analyses) followed by The Netherlands, China and Germany. The journal Radiology published 24 studies. The most common modality reported was positron emission tomography (PET) or PET computed tomography (36 instances), followed by magnetic resonance imaging (30 instances) and computed tomography (27 instances). Cardiac (19 meta-analyses), abdominal (18 meta-analyses), followed by neurological (12 meta-analyses) investigations were the most frequently encountered in the top 100 cited meta-analyses.
    CONCLUSIONS: The 100 top-cited meta-analyses encompass a broad range of imaging modalities and body regions. This may comprise a useful resource for identifying influential evidence-based diagnostic accuracy information in radiology.
    Keywords:  Bibliometrics; Medical imaging; Meta-analysis
    DOI:  https://doi.org/10.1186/s13244-020-00936-w
  6. PLoS One. 2020 ;15(11): e0242781
    Cebrino J, Portero de la Cruz S.
      BACKGROUND: Workplace violence in healthcare professionals has become a worldwide public health problem and has been the focus of numerous publications; however, currently, no macroscopic overviews of this research based on bibliometric analysis have been carried out. Therefore, the main aim of this study was to analyse the research trends focusing on workplace violence in healthcare personnel over the last 27 years.MATERIALS AND METHODS: A bibliometric study was conducted from 1992 to 2019 in the field of workplace violence in healthcare personnel using the Scopus database. The author co-citation analysis was carried out using VOSviewer software. A worldwide map was created with Mapchart and word cloud image was created using Wordart. Descriptive and inferential statistics were applied.
    FINDINGS: 1791 records were analysed, 1376 of which (76.83%) were articles, with "Medicine" the most frequent subject category (58.91%). English was the predominant language (93.41%). From 2004 onwards, there was an exponential rise in the number of publications (R2 coefficient = 0.89; p < 0.0001) and the number of annual citations gradually increased from 1995 (R2 coefficient = 0.73; p < 0.0001). The University of Cincinnati (United States) was the institution (and country) with the highest number of publications (n = 30; n = 549), with D. M. Gates leading the ranking of the most productive authors (n = 21). Journal of Nursing Management was the most active journal publishing on the topic (n = 34) and the commonest keyword was "human/s" (16.43%).
    CONCLUSION: From 1992 to 2019, worldwide research into the published literature on workplace violence in healthcare personnel has grown steadily year by year, both in the number of documents and the number of citations. United States and their institutions and researchers dominates this research output.
    DOI:  https://doi.org/10.1371/journal.pone.0242781
  7. Urology. 2020 Nov 20. pii: S0090-4295(20)31393-5. [Epub ahead of print]
    Gabrielson AT, Huang MM, Harris KT, Schwen ZR, Partin AW, Bivalacqua TJ.
      OBJECTIVES: To perform bibliometric analysis of the top cited articles in urology as a guide for journal club article selection.METHODS: Bibliometric citation analysis was performed using Scopus. Tables illustrating the top cited clinical, basic science, and guidelines/position statements papers were constructed. Linear regression was used to determine association between h-index and number of citations.
    RESULTS: A total of 3,188,861 publications from 1788-2020 were analyzed. The top 100 cited clinical papers from 1788-2020, top 100 cited contemporary clinical papers from 2000-2020, top 25 cited basic science papers, and the top 25 cited guidelines/position statement papers were reported. Median number of citations in the top 100 cited clinical papers was 1,463 (IQR 1,186-1,821). Memorial Sloan Kettering Cancer Center (12), Johns Hopkins University (6), and Harvard University (6) contributed the most top cited clinical papers in urology. Urologic oncology was the most represented subspecialty in both clinical (75%) and basic science (96%) papers. First author and last author h-index were found to correlate with the number paper citations in the top 100 cited clinical papers from 1788-2020 (first author β:5.3, p=0.003, last author β:4.5, p=0.03). Only 7% of the most cited clinical papers in urology were from female first authors, which was not statistically significantly different from those reported in prior publications published in 2009 and 2013.
    CONCLUSION: Contemporary citation analysis of indexed manuscripts in urology may serve as a valuable educational tool for urologists and trainees.
    Keywords:  Bibliometrics; Citation Analysis; Classic Articles
    DOI:  https://doi.org/10.1016/j.urology.2020.11.019
  8. World Neurosurg. 2020 Nov 18. pii: S1878-8750(20)32433-5. [Epub ahead of print]
    Deora H, Shahid AH, Paul RA, Tripathi M, Nanda A.
      BACKGROUND: A scientific publication is a mirror that defines the image of a researcher in his academic and professional world. Neurosurgery and Journal of Neurosurgery(JNS) are the two most reputed journals in the neurosurgical community.METHODS: We evaluated all the 'original articles' published in these two journals in the last issue of the year/December(2000-2019). We excluded all review articles and determined number of authors, institutions and highest educational degrees. Individual abstracts were evaluated for the nature of the study, population, citations with individual and comparative statistical analyses.
    RESULTS: A total of 682 original articles were analyzed. Neurosurgery had an increase in the number of authors(8.0±4.11 compared to 5.65±1.99), increase in title word count(15.14±5.05 from 13.2±4.46) and an increase in basic science research(0.9% to 11.6%). Retrospective studies increased in JNS(35.8% to 46.8%)with fewer studies on animals(18.4% to 8.1%). An increase in number of authors from 6.1±2.6 to 7.2±3.2 and title count was similar. Among the two journals, citation score for JNS improved faster when compared to Neurosurgery, consistently. Studies on adult patients received more citations than animal or pediatric studies. Clinical research garnered 19% more citations along with research with more collaborating institutes(coefficient=3.5). Title count had a weak negative correlation to citations received.
    CONCLUSION: Multi-author and multi-institutional studies ensure greater expertise and thus better impact. Limited by the sample size only a weak correlation was found with increased title count and retrospective studies with citations though their increase is an indicator of future trends. Both journals have shown a steady increase in their impact and quality of publications. To the best of our knowledge, our study is the first to examine the correlation of various factors and citations in the field of neurosurgery in the post-2000 era.
    Keywords:  Journal of Neurosurgery; Neurosurgery; article; citation; multi-institutional; publication; study
    DOI:  https://doi.org/10.1016/j.wneu.2020.11.058
  9. BMC Complement Med Ther. 2020 Nov 23. 20(1): 353
    Ng JY.
      BACKGROUND: Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2, and responsible for a global pandemic. Despite there being no known vaccines or medicines that prevent or cure COVID-19, many traditional, integrative, complementary and alternative medicines (TICAMs) have been touted as the solution, as well as researched as a potential remedy globally. This study presents a bibliometric analysis of global research trends at the intersection of TICAM and COVID-19.METHODS: SCOPUS, MEDLINE, EMBASE, AMED and PSYCINFO databases were searched on July 5, 2020, with results being exported on the same day. All publication types were included, however, articles were only deemed eligible if they made mention of one or more TICAMs for the potential prevention, treatment, and/or management of COVID-19 or a health issue indirectly resulting from the COVID-19 pandemic. The following eligible article characteristics were extracted: title; author names, affiliations, and countries; DOI; publication language; publication type; publication year; journal (and whether it is TICAM-focused); 2019 impact factor, and TICAMs mentioned.
    RESULTS: A total of 296 eligible articles were published by 1373 unique authors at 977 affiliations across 56 countries. The most common countries associated with author affiliation included China, the United States, India and Italy. The vast majority of articles were published in English, followed by Chinese. Eligible articles were published across 157 journals, of which 33 were TICAM-focused; a total of 120 journals had a 2019 impact factor, which ranged from 0.17 to 60.392. A total of 327 TICAMs were mentioned across eligible articles, with the most common ones including: traditional Chinese medicine (n = 94), vitamin D (n = 67), melatonin (n = 16), phytochemicals (n = 12), and general herbal medicine (n = 11).
    CONCLUSIONS: This study provides researchers and clinicians with a greater knowledge of the characteristics of articles that been published globally at the intersection of COVID-19 and TICAM to date. At a time where safe and effective vaccines and medicines for the prevention and treatment of COVID-19 have yet to be discovered, this study provides a current snapshot of the quantity and characteristics of articles written at the intersection of TICAM therapies and COVID-19.
    Keywords:  Bibliometric analysis; COVID-19; Complementary and alternative medicine; Coronavirus; Herbal; Integrative medicine; Research trends; Traditional Chinese medicine; Traditional medicine
    DOI:  https://doi.org/10.1186/s12906-020-03151-8
  10. JMIR Mhealth Uhealth. 2020 Nov 26. 8(11): e19391
    Kulakli A, Shubina I.
      BACKGROUND: Mobile apps are viewed as a promising opportunity to provide support for patients who have posttraumatic stress disorder (PTSD). The development of mobile technologies and apps shows similar trends in PTSD treatment. Therefore, this emerging research field has received substantial attention. Consequently, various research settings are planned for current and further studies.OBJECTIVE: The aim of this study was to explore the scientific patterns of research domains related to mobile apps and other technologies for PTSD treatment in scholarly publications, and to suggest further studies for this emerging research field.
    METHODS: We conducted a bibliometric analysis to identify publication patterns, most important keywords, trends for topicality, and text analysis, along with construction of a word cloud for papers published in the last decade (2010 to 2019). Research questions were formulated based on the relevant literature. In particular, we concentrated on highly ranked sources. Based on the proven bibliometric approach, the data were ultimately retrieved from the Web of Science Core Collection (Clarivate Analytics).
    RESULTS: A total of 64 studies were found concerning the research domains. The vast majority of the papers were written in the English language (63/64, 98%) with the remaining article (1/64, 2%) written in French. The articles were written by 323 authors/coauthors from 11 different countries, with the United States predominating, followed by England, Canada, Italy, the Netherlands, Australia, France, Germany, Mexico, Sweden, and Vietnam. The most common publication type was peer-reviewed journal articles (48/64, 75%), followed by reviews (8/64, 13%), meeting abstracts (5/64, 8%), news items (2/64, 3%), and a proceeding (1/64, 2%). There was a mean of 6.4 papers published per year over the study period. There was a 100% increase in the number of publications published from 2016 to 2019 with a mean of 13.33 papers published per year during this latter period.
    CONCLUSIONS: Although the number of papers on mobile technologies for PTSD was quite low in the early period, there has been an overall increase in this research domain in recent years (2016-2019). Overall, these findings indicate that mobile health tools in combination with traditional treatment for mental disorders among veterans increase the efficiency of health interventions, including reducing PTSD symptoms, improving quality of life, conducting intervention evaluation, and monitoring of improvements. Mobile apps and technologies can be used as supportive tools in managing pain, anger, stress, and sleep disturbance. These findings therefore provide a useful overview of the publication trends on research domains that can inform further studies and highlight potential gaps in this field.
    Keywords:  Web of Science; bibliometric; co-word analysis; mobile apps; mobile technologies; posttraumatic stress disorder (PTSD); text analysis; treatment
    DOI:  https://doi.org/10.2196/19391
  11. Heliyon. 2020 Nov;6(11): e05493
    Morán-Mariños C, Pacheco-Mendoza J, Metcalf T, De la Cruz Ramirez W, Alva-Diaz C.
      Socioeconomic and cultural factors coupled with an inability to control many endemic and emerging diseases have resulted in a growing incidence of epilepsy cases in Latin America. This study aimed to analyze and describe scientific research output trends in epilepsy research for the period 1989-2018. Publications were extracted from Scopus indexed journals. Bibliometric analysis was used to analyze scientific output including number of annual publications, documents, and publication characteristics. A mapping analysis using VOSviewer software visualized collaborative network analysis, co-citation analysis, and keyword co-occurrence analysis. SciVal quantitatively analyzed distribution of countries, institutions, citation counts, H-index, and research collaborative partnerships. A total of 176507 records were initially retrieved after which 5636 were analyzed. Overall, an increasing trend for publication output was observed from 19 articles in 1989 to 342 in 2018; the number of publications significantly increased over the past 20 years (p = 0.0065). The majority of publications were original articles (74.4%). Brazil had the most scientific production (55.2%), followed by Mexico (15.4%) and Argentina (10%). Extra-regional collaboration was primarily with the United States, United Kingdom, and Canada; intraregional collaboration was low. The most common area of investigation by co-occurrences was "diagnostic research" (37.2%), with studies based on electroencephalography and nuclear magnetic resonance. Epilepsy research in Latin America has seen a steady growth with significant increases over the past 20 years. Brazil, Mexico, and Argentina are the most productive countries in the field collaborating primarily with extra-regional countries of high-income.
    Keywords:  Bibliometrics; Biomedical research; Epidemiology; Epilepsy; Information management; Information science; Intersectoral collaboration; Latin America; Network analysis; Neurology
    DOI:  https://doi.org/10.1016/j.heliyon.2020.e05493
  12. J Clin Transl Sci. 2020 Apr 02. 4(4): 336-344
    Yu F, Van AA, Patel T, Mani N, Carnegie A, Corbie-Smith GM, Carey T, Buse J, Dave G.
      Introduction: To enhance the performance evaluation of Clinical and Translational Science Award (CTSA) hubs, we examined the utility of advanced bibliometric measures that go beyond simple publication counts to demonstrate the impact of translational research output.Methods: The sampled data included North Carolina Translational and Clinical Science Institute (NC TraCS)-supported publications produced between September 2008 and March 2017. We adopted advanced bibliometric measures and a state-of-the-art bibliometric network analysis tool to assess research productivity, citation impact, the scope of research collaboration, and the clusters of research topics.
    Results: Totally, 754 NC TraCS-supported publications generated over 24,000 citation counts by April 2017 with an average of 33 cites per article. NC TraCS-supported research papers received more than twice as many cites per year as the average National Institute of Health-funded research publications from the same field and time. We identified the top productive researchers and their networks within the CTSA hub. Findings demonstrated the impact of NC TraCS in facilitating interdisciplinary collaborations within the CTSA hub and across the CTSA consortium and connecting researchers with right peers and organizations.
    Conclusion: Both improved bibliometrics measures and bibliometric network analysis can bring new perspectives to CTSA evaluation via citation influence and the scope of research collaborations.
    Keywords:  CTSA evaluation; bibliometrics; network analysis; research impact measurement; translational research
    DOI:  https://doi.org/10.1017/cts.2020.29
  13. Plast Reconstr Surg. 2020 Dec;146(6): 808e-815e
    Boyd CJ, Ananthasekar S, Kurapati S, King TW.
      BACKGROUND: Social media are transforming the dissemination of published research. This influence brought the advent of a new metric, altmetrics, which seeks to quantify the influence of research in real time based on an article's attention online. This study aims to determine the correlation between altmetrics ratings for articles with traditional bibliometrics of impact factor and citation rate.METHODS: The 10 most cited articles in the top 15 plastic surgery journals were determined for 2013 and 2016. The 2013 articles allow for a 5-year lag time, whereas 2016 data provide another timepoint for comparison. Altmetric scores and citation count were collected for each article. Impact factor and Twitter account age were determined for each journal. Statistical analysis was completed using descriptive statistics, and Pearson and Spearman correlation coefficients.
    RESULTS: In both 2013 and 2016, there was a weak positive correlation between citations and Altmetric score (r = 0.2620, p = 0.0012; r = 0.3564, p < 0.0001, respectively) and between impact factor and the Altmetric score (r = 0.2419, p = 0.0040; r = 0.3887, p = < 0.0001, respectively). Twitter was the main contributor to the Altmetric score in both 2013 and 2016.
    CONCLUSIONS: Altmetric scores and traditional bibliometrics are not strongly correlated with one another in the plastic surgery literature at this point in time. Still, the short- and long-term impact of a publication might be determined through the combined analysis of citation count, impact factor, and Altmetric scores.
    DOI:  https://doi.org/10.1097/PRS.0000000000007378
  14. Acta Neurol Belg. 2020 Nov 23.
    Danis A, Kutluk MG.
      Although cerebral palsy (CP), which affects the quality of life of many children and their families, is the most common cause of motor dysfunction in children, no comprehensive bibliometric study has holistically evaluated the publications on CP. This study aimed to analyze the scientific outputs published on CP in pediatrics research between 1980 and 2019 using bibliometric and statistical methods, and reveal new study trends in this field. The literature search was performed in the Web of Science database using the keyword cerebral palsy in the title section of the articles published only in the pediatrics research field. Four-thousand seventy-five publications were obtained in the field of pediatrics research on CP, 3027 of which were articles. We shared abstract information of 3027 articles published between 1980 and 2019 with this comprehensive bibliometric study, which will be a useful guide for physicians and scientists on the global outcomes of CP, and we discussed new trends in this topic. We think that comprehensive bibliometric analyzes on subjects that we frequently encounter in clinics and which are widely researched will contribute to the field.
    Keywords:  Bibliometric analysis; Cerebral palsy; Child; Pediatric; Trends
    DOI:  https://doi.org/10.1007/s13760-020-01549-2
  15. BMJ Open. 2020 Nov 23. 10(11): e043970
    Buffone B, Djuana I, Yang K, Wilby KJ, El Hajj MS, Wilbur K.
      OBJECTIVES: The global distribution of health professionals and associated training programmes is wide but prior study has demonstrated reported scholarship of teaching and learning arises from predominantly Western perspectives.DESIGN: We conducted a document analysis to examine authorship of recent publications to explore current international representation.
    DATA SOURCES: The table of contents of seven high-impact English-language health professional education journals between 2008 and 2018 was extracted from Embase.
    ELIGIBILITY CRITERIA: The journals were selected according to highest aggregate ranking across specific scientific impact indices and stating health professional education in scope; only original research and review articles from these publications were included for analysis.
    DATA EXTRACTION AND SYNTHESIS: The table of contents was extracted and eligible publications screened by independent reviewers who further characterised the geographic affiliations of the publishing research teams and study settings (if applicable).
    RESULTS: A total 12 018 titles were screened and 7793 (64.8%) articles included. Most were collaborations (7048, 90.4%) conducted by authors from single geographic regions (5851, 86%). Single-region teams were most often formed from countries in North America (56%), Northern Europe (14%) or Western Europe (10%). Overall lead authorship from Asian, African or South American regions was less than 15%, 5% and 1%, respectively. Geographic representation varied somewhat by journal, but not across time.
    CONCLUSIONS: Diversity in health professional education scholarship, as marked by nation of authors' professional affiliations, remains low. Under-representation of published research outside Global North regions limits dissemination of novel ideas resulting in unidirectional flow of experiences and a concentrated worldview of teaching and learning.
    Keywords:  diversity; health professional education; inclusion; publication; research; scholarship
    DOI:  https://doi.org/10.1136/bmjopen-2020-043970
  16. PLoS One. 2020 ;15(11): e0241772
    Hou J, Li H, Zhang Y.
      In science, sleeping beauties (SBs) denotes a special phenomenon of the diffusion of scientific knowledge based on citation trajectories, the awakening of which is also measured through changes in the citations index. However, the rapid advancement of social media has altered the mode of scientific communication and knowledge diffusion. This study aims to re-identify SBs and its Prince from the perspective of comprehensive indicators, which involves the analysis of Altmetrics indexes and Citation index, and investigate the awakening mechanism of A-SB to supplement the research on the awakening mechanism of SBs. By combining Ab index, we redefined the Prince, which makes A-SB receive high attention after a long Sleeping period and reflects the most prominent academic or social behavior that awakens and sustains the Awakening of A-SB. Then we conducted empirical research on the retrieved PLOS Biology collection and examined Prince after identifying the A-SB. The analysis and summary of the characteristics of the identified A-SB and Prince revealed the SBs' awakening mechanism under the comprehensive trajectory based on Altmetrics from the three dimensions of the influence between the indicators, the overall evolution trajectory of A-SB, and literature bibliometric attributes. In the trajectory of Delayed Recognition stage of A-SB, we define the Dogsleep of SBs, which mirrors that the instability of the Sleeping of SBs will generate a specific negative impact on Prince of A-SB and Awakening intensity. Besides, the literature bibliometric attributes cannot reflect the tendency of users to read academic papers, which again proves that the traditional citation index cannot be neglected in the awakening mechanism of A-SB. Overall, this study demonstrates the addition of the Altmetrics indexes as a useful complement, illustrating the inheritance and connection between the SBs based on the comprehensive trajectory and the SBs based on the citation diffusion trajectory.
    DOI:  https://doi.org/10.1371/journal.pone.0241772
  17. Andrologia. 2020 Nov 24. e13842
    Agarwal A, Panner Selvam MK, Baskaran S, Finelli R, Leisegang K, Barbăroșie C, Pushparaj PN, Robert KA, Ambar R, Iovine C, Durairajanayagam D, Henkel R.
      Assisted reproductive technologies (ART) are considered as one of the primary management options to address severe male factor infertility. The purpose of this study was to identify the research trends in the field of male infertility and ART over the past 20 years (2000-2019) by analysing scientometric data (the number of publications per year, authors, author affiliations, journals, countries, type of documents, subject area and number of citations) retrieved using the Scopus database. We used VOS viewer software to generate a network map on international collaborations as well as a heat map of the top scientists in this field. Our results revealed a total of 2,148 publications during this period with Cleveland Clinic Foundation contributing the most (n = 69). The current scientometric analysis showed that the research trend on ART has been stable over the past two decades. Further in-depth analysis revealed that density gradient centrifugation (46%) and intracytoplasmic sperm injection (59.2%) are the most reported techniques for sperm separation and ART, respectively. Additionally, azoospermia was the most studied clinical scenario (60.6%), with majority of articles reporting pregnancy rate (47.25%) as the primary reproductive outcome for ART. This study provides insight into the current focus of research in the area of male infertility and ART as well as the areas that require further research in future.
    Keywords:  assisted reproductive technique; male infertility; publications; research trend; scientometric analysis
    DOI:  https://doi.org/10.1111/and.13842
  18. Front Med (Lausanne). 2020 ;7 584728
    Zhao Y, Zhang X, Song Z, Wei D, Wang H, Chen W, Sun G, Ma W, Chen K.
      Assay for transposase-accessible chromatin using sequencing (ATAC-seq) is associated with significant progress in biological research and has attracted increasing attention. However, the impact of ATAC-seq on cancer biology has not been objectively analyzed. We categorized 440 ATAC-seq publications according to the publication date, type, field, and country. R 3.6.2 was used to analyze the distribution of research fields. VOSviewer was used for country co-authorship and author co-authorship analyses, and GraphPad Prism 8 was used for correlation analyses of the factors that may affect the number of articles published in different countries. We found that ATAC-seq plays roles in carcinogenesis, anticancer immunity, targeted therapy, and metastasis risk predictions and is most frequently used in studies of leukemia among all types of cancer. We found a significantly strong correlation between the top 10 countries in terms of the number of publications and the gross expenditure on research and development (R&D), the number of universities, and the number of researchers. At present, ATAC-seq technology is undergoing a period of rapid development, making it inseparable from the emphasis and investment in scientific research by many countries. Collectively, ATAC-seq has advantages in the study of the cancer mechanisms because it can detect nucleic acids and thus has good application prospects in the field of cancer, especially in leukemia studies. As a country's economic strength increases and the emphasis on scientific research deepens, ATAC-seq will definitely play a more significant role in the field of cancer biology.
    Keywords:  ATAC-seq; bibliometric analysis; cancer biology; leukemia; open chromatin
    DOI:  https://doi.org/10.3389/fmed.2020.584728
  19. J Clin Neurosci. 2020 Nov 24. pii: S0967-5868(20)31587-3. [Epub ahead of print]
    Kerr N, Kerr J, Sheridan M, Holcombe A.
      A concerning phenomenon has been identified within the scientific literature. In multiple fields, systematic efforts to replicate peer reviewed studies have been successful in fewer than half of the originals attempted. Currently it is unclear how many influential neurosurgical trials have undergone direct replication. In this study we conducted a publication search to estimate the proportion of classic trials (>400 citations) to have undergone independent direct replication. Published replications would then be assessed for agreement with the original study findings. Our search included all journal articles in the Web of Science written in English and published between 1900 and 2019. This yielded 110 highly-cited trials published in 28 medical journals. Screening of the citation index for these classic studies (113,387 articles) identified 4632 articles to be scrutinised for evidence of replication. Review of these articles did not find any self-identified direct replication studies. This apparent absence of direct replication of classic trials in neurosurgery raises questions about the strength of the evidence base for widespread neurosurgical practices. Direct replication studies must be attempted and published in order to confirm the robustness of influential findings from neurosurgical research.
    Keywords:  Citation classics; Clinical trials; Neurosurgery; Replication; Validation
    DOI:  https://doi.org/10.1016/j.jocn.2020.10.028
  20. JNCI Cancer Spectr. 2020 Dec;4(6): pkaa065
    Corn BW, Feldman D, Schapira L, Steensma DP, Loprinzi CL, Bian J.
      The words cure and hope are important terms in oncology, reflecting a balance of aspirations and realism for physicians and patients. Yet, some have suggested that oncologists are reluctant to use these terms. We tested this hypothesis by performing a bibliometric analysis of the frequency of use of these words in JAMA Oncology (JAMA Oncol) and the Journal of Clinical Oncology (JCO). The text of all articles in 3 categories-primary research, editorials, and narrative essays-appearing in JCO from 2000 to 2018 and in JAMA Oncol from 2015 to 2019 was analyzed. These analyses compared, across these categories, the proportion of articles containing the words cure and hope, as well as the proportion of total sentences containing these words. There were statistically significant differences in frequency of the use of the terms cure and hope as a function of the type of article published in the JCO and JAMA Oncol (2-sided P values ranging from .005 to <.001). Results were similar for both journals, with minor exceptions. Both hope and cure were used in a greater number of articles and sentences in the narrative and editorial categories than in primary research. Moreover, hope was used more often in narrative essays than in editorials. The relative reluctance to use these terms in more scientifically oriented original reports, despite concomitant improvements in oncologic outcomes, may reflect a bias worthy of future exploration.
    DOI:  https://doi.org/10.1093/jncics/pkaa065
  21. Prenat Diagn. 2020 Nov 22.
    Lu YL, Bianchi DW.
      OBJECTIVE: To understand the evolution of the field of prenatal diagnosis over the past four decades.METHOD: We analyzed the publications in the journal Prenatal Diagnosis from its inception in 1980 to 2019 using Medical Subject Headings (MeSH) to examine the major research topics and trends. The results were analyzed by 10-year intervals.
    RESULTS: Publications on prenatal cytogenetics, congenital anomalies and fetal imaging predominated during the first three decades, with a steady increase in molecular genetics over time. Publications on NIPT did not appear until the most recent decade and are likely under-counted because there was no MeSH term for NIPT until 2020.
    CONCLUSION: The topics covered in Prenatal Diagnosis articles have evolved considerably over the past four decades and reflect a response to advances in technology and widespread incorporation of prenatal screening and diagnosis into standard obstetric care. The strengths of this analysis are its objective nature, its use of the standard MeSH terms used for coding, and application of a novel cluster analysis to visualize trends. The analysis also pointed out the fact that MeSH terms in this sub-specialty area are often inconsistent due to manually coding based on individual subject matter expertise in an individual. This article is protected by copyright. All rights reserved.
    DOI:  https://doi.org/10.1002/pd.5871
  22. Stem Cell Res Ther. 2020 Nov 25. 11(1): 498
    Chen C, Lou Y, Li XY, Lv ZT, Zhang LQ, Mao W.
      BACKGROUND: Mesenchymal stem cells (MSCs) have important research value and broad application prospects in the cardiovascular disease. This study provides information on the latest progress, evolutionary path, frontier research hotspots, and future research developmental trends in this field.METHODS: A knowledge map was generated by CiteSpace and VOSviewer analysis software based on data obtained from the literature on MSCs in the cardiovascular field.
    RESULTS: The USA and China ranked at the top in terms of the percentage of articles, accounting for 34.306% and 28.550%, respectively. The institution with the highest number of research publications in this field was the University of Miami, followed by the Chinese Academy of Medical Sciences and Harvard University. The research institution with the highest ACI value was Harvard University, followed by the Mayo Clinic and the University of Cincinnati. The top three subjects in terms of the number of published articles were cell biology, cardiovascular system cardiology, and research experimental medicine. The journal with the most publications in this field was Circulation Research, followed by Scientific Reports and Biomaterials. The direction of research on MSCs in the cardiovascular system was divided into four parts: (1) tissue engineering, scaffolds, and extracellular matrix research; (2) cell transplantation, differentiation, proliferation, and signal transduction pathway research; (3) assessment of the efficacy of stem cells from different sources and administration methods in the treatment of acute myocardial infarction, myocardial hypertrophy, and heart failure; and (4) exosomes and extracellular vesicles research. Tissue research is the hotspot and frontier in this field.
    CONCLUSION: MSC research has presented a gradual upward trend in the cardiovascular field. Multidisciplinary intersection is a characteristic of this field. Engineering and materials disciplines are particularly valued and have received attention from researchers. The progress in multidisciplinary research will provide motivation and technical support for the development of this field.
    Keywords:  Cardiovascular; Knowledge mapping analysis; Mesenchymal stem cells; Visualization
    DOI:  https://doi.org/10.1186/s13287-020-02009-7
  23. Theory Biosci. 2020 Nov 25.
    Painter DT, van der Wouden F, Laubichler MD, Youn H.
      To what extent do simultaneous innovations occur and are independently from each other? In this paper we use a novel persistent keyword framework to systematically identify innovations in a large corpus containing academic papers in evolutionary medicine between 2007 and 2011. We examine whether innovative papers occurring simultaneously are independent from each other by evaluating the citation and co-authorship information gathered from the corpus metadata. We find that 19 out of 22 simultaneous innovative papers do, in fact, occur independently from each other. In particular, co-authors of simultaneous innovative papers are no more geographically concentrated than the co-authors of similar non-innovative papers in the field. Our result suggests producing innovative work draws from a collective knowledge pool, rather than from knowledge circulating in distinct localized collaboration networks. Therefore, new ideas can appear at multiple locations and with geographically dispersed co-authorship networks. Our findings support the perspective that simultaneous innovations are the outcome of collective behavior.
    Keywords:  Evolutionary medicine; Independence; Keyword extraction; Novelty; Simultaneous innovation
    DOI:  https://doi.org/10.1007/s12064-020-00333-3
  24. J Clin Epidemiol. 2020 Nov 20. pii: S0895-4356(20)31179-3. [Epub ahead of print]
    Innocenti T, Salvioli S, Giagio S, Feller D, Cartabellotta N, Chiarotto A.
      OBJECTIVE: The main aims of this meta-research study conducted among high impact rehabilitation journals were: 1) to evaluate if the use of reporting guidelines (RGs) was declared, 2) to categorize the declared use as appropriate or inappropriate.STUDY DESIGN AND SETTING: Cross-sectional analysis of a random sample of 200 studies published in the period 2010-2019 in five generic rehabilitation journals with the highest 5-year impact factor. Randomized controlled trials, systematic reviews, observational studies and diagnostic studies were included. Prevalence with 95% confidence intervals (CIs) were estimated for the main outcomes.
    RESULTS: Among the 200 selected studies, 17.5% (95% CI: 12.2-22.8%) declared using RGs. Among these studies, 48.6% (95% CI: 32-65.1%) declared an appropriate use. There was an increasing trend over time for authors to report the use of RGs (OR: 1.31; 95% CI: 1.13-1.53). Systematic reviews (n=54) reported more frequently the use of RGs than other study designs (35.2%).
    CONCLUSION: In high impact rehabilitation journals, a small minority of article authors declared the use of RGs. In approximately half of these studies RGs were used inappropriately. There is an urgent need to improve the use of RGs in this field of research.
    Keywords:  Meta-research; Physiotherapy; Rehabilitation; Reporting guideline; Research reporting; Systematic reviews
    DOI:  https://doi.org/10.1016/j.jclinepi.2020.11.010
  25. Plast Reconstr Surg. 2020 Dec;146(6): 759e-767e
    Luby AO, Ranganathan K, Matusko N, Buchman SR.
      BACKGROUND: As craniofacial fellowship positions outnumber the availability of academic craniofacial jobs, it is important to understand the factors associated with securing an academic position after fellowship. The purpose of this study was to evaluate the impact of bibliometric indices and trainee demographics on the ability to obtain a full-time academic plastic surgery position on completion of a craniofacial fellowship.METHODS: Craniofacial fellowship graduates between 2009 and 2018 (n = 182) were identified. Initial job placement and demographic data were collected; bibliometric indices at fellowship completion were calculated. Chi-square and Fisher's exact tests and multivariable logistic regression were used to assess the association of select factors with job placement.
    RESULTS: Of the 48.9 percent of fellows that secured academic positions, 39.3 percent trained at five fellowship institutions. The majority of those completing residency at top institutions for academic surgery and research entered academic positions at fellowship completion. Geography influenced academic placement, as 72.7 percent of trainees in the Northeast secured academic positions. Only 20.3 percent of fellows completed dedicated postgraduate research time, but among these, 70.3 percent entered academic jobs. The h-index (OR, 1.14; p = 0.01) and total manuscripts (OR, 1.04; p = 0.02) were significantly associated with academic practice while adjusting for other covariates.
    CONCLUSIONS: Although residency training institution, geographic location, and postgraduate research may influence academic placement, the h-index and total manuscripts represent the best predictors of academic careers after craniofacial fellowship. This information is valuable for applicants who aspire to be academic craniofacial surgeons, and for programs and educators who can use these data to identify applicants with a propensity for academics.
    DOI:  https://doi.org/10.1097/PRS.0000000000007340
  26. Stud Health Technol Inform. 2020 Nov 23. 275 167-171
    Pool J, Fatehi F, Hassandoust F, Akhlaghpour S.
      Health data privacy is an important research stream due to the high impacts on the success of digital health transformation and implementation. Neglecting to safeguard data confidentially and integrity and mitigate risks associated with unauthorized access will lead to failures in materializing benefit from digital health. This study aims to present a bibliometric analysis of health data privacy and provide a platform for future directions. We conducted a literature search between 2010 and 2020 in the Web of Science (WoS) database, resulted in 1,752 records. As part of the bibliometric analysis, concept mapping of health data privacy researches was depicted by network visualization and overlay visualization. These two visualizations represent five research fronts and emerging topics (e.g., digital health, blockchain, the internet of things (IoT)). Finally, we chart directions for future research on health data privacy, highlighting emerging topics, and boundary-breaking alternatives (e.g., GDPR, contact tracing apps in the context of pandemics).
    Keywords:  Privacy; cybersecurity; data protection; digital health; health data
    DOI:  https://doi.org/10.3233/SHTI200716
  27. Nature. 2020 Nov;587(7835): S104-S105
    Boytchev H.
      
    Keywords:  Databases; Funding; Institutions; Policy; Publishing; Research management
    DOI:  https://doi.org/10.1038/d41586-020-03318-w
  28. J Neurol Sci. 2020 Oct 22. pii: S0022-510X(20)30522-0. [Epub ahead of print] 117186
    Sheppard JP, Lagman C, Nguyen T, Yokoi H, Jeong SH, Luong P, Chen CHJ, Ong V, French A, Franks AM, Kwan I, Mekonnen M, Ng E, Evans A, Preet K, Udawatta M, Yang I.
      BACKGROUND: Research productivity is a key criterion for applicant selection reported by residency program directors. Research volume reported on neurosurgery residency applications has risen steadily over the past decade.OBJECTIVE: Perform retrospective bibliographic searches of successful applicants who matched into U.S. neurosurgery residency programs from 2011 to 2018, and assess the relationship between academic publishing and residency placement.
    METHODS: Gender, MD/PhD status, U.S. News research ranking of medical school, and international medical graduate status (IMG) were determined for 1634 successful applicants from 2011 to 2018. Indexed publications before and after the start of residency were tabulated by Scopus®. Publication counts were stratified by first author, basic/clinical science, case reports, reviews, or other research. We then compared publishing trends across demographic variables and match cohorts.
    RESULTS: Average pre-residency publications increased from 2.6 [1.7, 3.4] in 2011 to 6.5 [5.1, 7.9] in 2018. Men, PhD-holders, Top 20 and Top 40 U.S. medical school graduates, and IMGs had higher pre-residency publication counts overall. After stratifying by match cohort, however, there was no significant effect of gender on pre-residency publications. Applicants matching into residency programs with highly ranked affiliated hospitals had significantly higher pre-residency publications.
    CONCLUSION: Publishing volume of successful neurosurgery applicants in the U.S. has risen recently and is associated with the stature of matched residency programs. Given the gap between verifiable and claimed research on residency applications, attention is needed to objectively evaluate research credentials in the selection process. The impending phase out of USMLE step 1 scores may increase emphasis on academic productivity.
    Keywords:  Match; Neurosurgery; Publication; Residency
    DOI:  https://doi.org/10.1016/j.jns.2020.117186
  29. J Med Internet Res. 2020 Nov 09.
    Grammes N, Millenaar D, Fehlmann T, Kern F, Böhm M, Mahfoud F, Keller A.
      BACKGROUND: The global pandemic caused by the severe acute respiratory syndrome-coronarvirus-2 (SARS-CoV-2) leading to the coronavirus disease 2019 (COVID-19) has led to immediate and massive worldwide research activities. Rapid publication of research data may be desirable but also carries the risk of quality loss.OBJECTIVE: This analysis aimed to correlate the severity of the COVID-19 outbreak with its related scientific output per region.
    METHODS: All articles related to the COVID-19 pandemic were retrieved from Web-of-Science and analyzed utilizing the web application SciPE (Science-Performance-Evaluation), allowing large data scientometric analyses regarding global geographical distribution of scientific output.
    RESULTS: A total of 7,185 articles, including 2,898 articles, 2,275 editorial materials, 2,646 early access, 1,621 letters and 711 reviews and other contributions were extracted. The top three countries involved in COVID-19 research were the United States (US), China, and Italy. The regional number of confirmed COVID-19 cases or deaths correlated with the scientific research efforts. The US was most active in terms of collaborative efforts, sharing a significant amount of manuscripts with the United Kingdom (UK), China, and Italy. For China, the US was the frequent cooperating nation, followed by the UK.
    CONCLUSIONS: The research landscape related to COVID-19 is rapidly developing and is driven by countries with a general strong research output but is also strongly affected by countries with high prevalence of COVID-19 cases. The US dominates international collaborative efforts.
    DOI:  https://doi.org/10.2196/24514
  30. Lancet Psychiatry. 2020 Nov 23. pii: S2215-0366(20)30469-7. [Epub ahead of print]
    Woelbert E, Lundell-Smith K, White R, Kemmer D.
      High-quality data on funding for mental health research are essential to mapping funding levels, identifying gaps in the funding landscape, and tracking the impact of research funding. To date, quantitative analyses of research funding in mental health have been restricted in scope. In this Health Policy paper, we present a comprehensive analysis of grant funding for mental health research as a starting point for discussion among stakeholders globally. We drew on a major international research database and used existing definitions and automated classification tools for mental health research. Our analysis shows a flat and stable trend over the years 2015-19 and highly unequal geographical distribution of funding, and reveals patterns of funding across different conditions and across the research spectrum. Improvements in data availability and quality, in the definitions delineating mental health research from other areas, and in automated classification tools are needed to ensure funders and policy makers can fully rely on the data and generate bespoke analyses as needed. We argue that collaborative reporting of funding for mental health research globally could help to inform and evaluate efforts to increase investments, to improve strategic dialogue, and to achieve the best possible allocation of finite resources.
    DOI:  https://doi.org/10.1016/S2215-0366(20)30469-7
  31. Nature. 2020 Nov;587(7835): S110-S111
      
    Keywords:  Databases; Institutions; Publishing; Research management
    DOI:  https://doi.org/10.1038/d41586-020-03320-2
  32. PLoS One. 2020 ;15(11): e0242283
    Marrone M, Linnenluecke MK.
      This article introduces Interdisciplinary Research Maps as a novel visualization technique to assist with interdisciplinary research analytics and to map common (and distinct) topics across publications from different disciplines. We detail the method for this technique which is based on entity linking and illustrate its application to a sample of articles sourced from the top business/management and environmental sciences journals. Both fields have separately been criticized for a lack of interdisciplinary research to co-create insights for tackling pressing environmental issues such as climate change. Our mapping approach provides a starting point for exploring similarities and differences in research topics across these fields. The mapping technique introduced here has broader applicability to facilitate the creation and exchange of knowledge across fields. We discuss avenues for visualization techniques to bridge the different fields by focusing on identifying common concepts to provide a basis for future analysis.
    DOI:  https://doi.org/10.1371/journal.pone.0242283
  33. Nature. 2020 Nov;587(7835): S103
    Crew B.
      
    Keywords:  Databases; Funding; Government; Institutions
    DOI:  https://doi.org/10.1038/d41586-020-03317-x
  34. Nature. 2020 Nov;587(7835): S116-S117
    Conroy G, Crew B, Tay A.
      
    Keywords:  Animal behaviour; Careers; Microbiome; Neuroscience; Particle physics
    DOI:  https://doi.org/10.1038/d41586-020-03322-0
  35. BJPsych Bull. 2020 Nov 24. 1-5
    Dhingra S, Killaspy H, Dowling S.
      AIMS AND METHOD: To investigate whether gender balance in academic psychiatry in the UK has improved since a 2005 initiative to encourage career progression for female academics in UK universities. We surveyed the gender of academic psychiatrists across the UK and compared our findings with our previous 2003 London-wide survey and with the Royal College of Psychiatrists' 2001 workforce census.RESULTS: The percentage of women in academic psychiatry posts in the UK more than doubled, from 20% in 2001 to 40% in 2019, with increases at senior lecturer (from 25 to 50%), reader/associate professor (from 29 to 48%) and professor level (from 11 to 21%). Outside London, men occupy 72% of all posts and 89% of professorial posts. Within London, men occupy 45% of all posts and 74% of professorial posts.
    CLINICAL IMPLICATIONS: The representation of women in academic psychiatry has improved but men continue to dominate at professorial level. Gender equality appears worse outside London. The situation is exacerbated by the diminishing availability of posts across the UK.
    Keywords:  Gender equality; United Kingdom; academic psychiatry; gender balance; women
    DOI:  https://doi.org/10.1192/bjb.2020.116
  36. Lang Speech. 2020 Nov 27. 23830920974710
    Fu Y, Wang H, Guo H, Bermúdez-Margaretto B, Domínguez Martínez A.
      The neural/mental operations involved in the process of visual word recognition (VWR) are fundamental for the efficient comprehension of written/printed words during reading. The present study used CiteSpace, a visual analysis software, to identify the intellectual landscape where VWR has been reviewed in the past decade. Thus, synthesized co-citation networks were analyzed to explore and discuss the main questions raised in the VWR literature: the research fronts and the emerging trends of research on this topic. Our results showed that the main questions addressed in VWR studies during the last decade have been focused on four main aspects related to "what," "where," "when," and "how" of VWR; to be specific, the different types of representations assessed during VWR ("what"), the locations and the timing of the brain activity involved in VWR ("where" and "when"), and the interactivity among different representations during processing ("how"). Among the revised studies, letter position coding was found to be the main topic of interest, possibly reflecting the critical role of this process. Furthermore, the evidence found in these studies consistently supported that VWR implies access to phonological, semantic, and morphological representations, which interact and modulate the processing of written words, particularly during early stages. Altogether, our findings showed the evolution in VWR literature regarding the different cognitive and neural operations involved in this process, highlighting the growing interest over the last decade toward the top-down way that mental representations interact.
    Keywords:  CiteSpace; Visual word recognition; bibliometrics; top-down processing
    DOI:  https://doi.org/10.1177/0023830920974710
  37. J Environ Manage. 2020 Nov 19. pii: S0301-4797(20)31566-8. [Epub ahead of print]278(Pt 2): 111641
    Ekundayo TC, Igwaran A, Oluwafemi YD, Okoh AI.
      Chlorine is the commonest and cheapest disinfectant used in drinking water and wastewater treatment at household, municipal and industrial levels. However, the uprising of microbial chlorine resistance (MCR) pose critical public health hazard concerns; because, its potentiate exposure to difficult-to-treat resistant pathogens. Therefore, this study aimed at evaluating the burden of MCR in drinking water/wastewater treatment and distribution systems (DWWTDS) via science mapping of research productivity (authors, countries, institutions), thematic conceptual framework, disciplines, research networks and associated intellectual landscape. MCR data were mined from Scopus and Web of Science based on optimized algorithms with the root key term "chlorine* resistant*'' and analysed for pre-set indicator variables. Results revealed 1127 documents from 442 journals and 1430% average growth rate (AGR) of research articles from 2017 to 2019 on MCR. Country-wise, the USA (n = 299), China (n = 119), and Japan (n = 43) ranked in the 1st, 2nd, and 3rd positions respectively, among the top participating countries in MCR research. MCR research had considerable performance in public health and sustainable concern subjects namely, Environmental Sciences & Ecology, Engineering, Microbiology, Water Resources, Biotechnology & Applied Microbiology, Food Science & Technology, Public, Environ & Occupational Health, Chemistry, Infectious Diseases, and Marine & Freshwater Biology; and with noticeable AGR in Environmental Sciences & Ecology (330%) and Infectious Diseases (130%). The study found biofilm-related thrusts (n = 90, 270% AGR) as main research hotspots on MCR. Overall, the study identified and discussed four important thematic areas of public health challenges in MCR that could promote increasing waterborne diseases due to (re)emerging pathogens, enteric viruses and dissemination in DWWTDS. In conclusion, this study provides comprehensive overview of the growing burden of MCR in DWWTDS and standout as a primer of information for researchers on MCR. It recommends direct, intentional and integrated research priorities on MCR to overcome accompanying public health and environmental threats. In addition, chlorine resistance in waterborne fungi have not received research attention. Research activities related to fungal chlorine resistance will be an invaluable future direction in DWWTDS and guide against exposure to waterborne pathogenic fungi and mycotoxins. It is unknown whether chlorine resistance can be acquired by horizontal gene transfer in microorganisms and future research should elucidate this important thrust.
    Keywords:  Antibiotic resistance; Bibliometric; Biofilms; Chlorine resistance; Drinking water; Fungal chlorine resistance; Wastewater
    DOI:  https://doi.org/10.1016/j.jenvman.2020.111641
  38. Nature. 2020 Nov;587(7835): 523
    Gadd E.
      
    Keywords:  Research management
    DOI:  https://doi.org/10.1038/d41586-020-03312-2