bims-evares Biomed News
on Evaluation of research
Issue of 2019‒09‒01
eighteen papers selected by
Thomas Krichel
Open Library Society

  1. ACS Omega. 2019 Jan 31. 4(1): 86-94
    Tomaszewski R.
      Identifying research gaps and generating research questions are often a first step in developing ideas for writing a research paper or grant proposal. The concept of substance-based bibliometrics uses the counts of substances in the scientific literature to better understand, assess, and clarify the state and impact of information in the chemical sciences. Connecting substances indexed to specific bioactivity or target indicators can lead to assessing the biochemical, biological, and medicinal relevance of substances as well as developing ideas for expanding drug design and discovery through identifying and modifying the structural features of molecules. This study uses Chemical Abstracts through the SciFinder database to count for the occurrence of substances in the scientific literature. The study sets out search strategies for discovering potential research gaps and new ideas through visualization of chemical structures with known bioactivity and target indicators. The author recommends that subject librarians integrate research gap training in their bibliographic instruction classes, particularly to upper-level undergraduate and graduate chemistry students.
  2. Nature. 2019 Aug;572(7771): 578-579
    Van Noorden R, Singh Chawla D.
    Keywords:  Databases; Ethics; Peer review; Publishing
  3. Int J Med Inform. 2019 Aug 13. pii: S1386-5056(18)30677-4. [Epub ahead of print]130 103947
    Gu D, Li T, Wang X, Yang X, Yu Z.
      BACKGROUND: In recent years, the development and application of emerging information technologies, such as artificial intelligence, cloud computing, Internet of Things, and wearable devices, has expanded the content of electronic health (e-health). Electronic health has become a research focus, but few studies have explored its knowledge structure from a global perspective.METHODS: To detect the evolution track, knowledge base and research hotspots of e-health, we conducted a series of bibliometric analyses on the retrieved 3,085 papers from the Web of Science core database in 1992-2017. We used several bibliometric tools, such as HistCite, CiteSpace, NetDraw, and NEViewer, to describe the evolution process, time-and-space knowledge map, and hotspots in e-health.
    RESULTS: The research results are as follows. (a) The number of publications has been obviously increasing after 2005 and according to the trend line it is expected to continue increase exponentially in the future. (b) Countries/regions conducting e-health research have close cooperative relationship, among which European countries have the closest cooperation. (c) Electronic health records, mobile health and health information technology are research hotspots in electronic health. Moreover, scholars also pay attention to the hot issues such as privacy, security, and quality improvement.
    CONCLUSIONS: Electronic health is a large and growing field with quite a number of research articles in medical journals. This study provides a comprehensive knowledge structure of electronic health for scholars in the healthcare informatics field, which can help them quickly grasp research hotspots and choose future research projects.
    Keywords:  Bibliometrics; Electronic health; Healthcare informatics; Knowledge structure
  4. Clin Trials. 2019 Aug 26. 1740774519868310
    Spence O, Hong K, Onwuchekwa Uba R, Doshi P.
      BACKGROUND: To improve reporting transparency and research integrity, some journals have begun publishing study protocols and statistical analysis plans alongside trial publications. We sought to assess the overall availability and characteristics of protocols and statistical analysis plans of randomized clinical trials published in the top five (by impact factor) general medicine journals.METHODS: All randomized clinical trials published in Annals of Internal Medicine, BMJ, JAMA, Lancet, and NEJM in 2016 were identified. For each randomized clinical trial, we searched for protocols and statistical analysis plans on journal websites (including supplementary material) and in the article, for example, a referenced publication or link to trial or institutional website. Characteristics of randomized clinical trials were extracted from the publication and clinical trial registry. A detailed assessment of protocols and statistical analysis plans was conducted in a 20% random sample of randomized clinical trials.
    RESULTS: Protocols were available for 299 (82%) trials, ranging from 50% in BMJ to >95% in NEJM and JAMA. Statistical analysis plans were available for 182 (50%) trials and varied from <10% for Annals of Internal Medicine, BMJ, and Lancet to 92% for NEJM. Of the 76 randomized clinical trials in the 20% random sample, 63 (83%) had a protocol but less than half (31; 44%) included an a priori (dated prior to patient enrollment) version of the protocol. Statistical analysis plans were available for 35 (46%) trials, and only 5 (7%) included an a priori version.
    CONCLUSION: Protocols and statistical analysis plans are publicly available for the majority of trials. However, the a priori versions of these documents are only available for a minority of trials. More attention must be paid to ensuring the public availability of a priori versions.
    Keywords:  Clinical trials; protocols; statistical analysis plan
  5. BMC Gastroenterol. 2019 Aug 30. 19(1): 158
    Zyoud SH, Smale S, Waring WS, Sweileh WM, Al-Jabi SW.
      BACKGROUND: The pathways and mechanism by which associations between the gut microbiome and the brain, termed the microbiome-gut-brain axis (MGBA), are manifest but remain to be fully elucidated. This study aims to use bibliometric analysis to estimate the global activity within this rapidly developing field and to identify particular areas of focus that are of current relevance to the MGBA during the last decade (2009-2018).METHODS: The current study uses the Scopus for data collection. We used the key terms "microbiome-gut-brain axis" and its synonyms because we are concerned with MGBA per se as a new concept in research rather than related topics. A VOSviewer version 1.6.11 was used to visualize collaboration pattern between countries and authors, and evolving research topics by analysis of the term co-occurrence in the title and abstract of publications.
    RESULTS: Between 2009 and 2018, there were 51,504 published documents related to the microbiome, including 1713 articles related to the MGBA: 829 (48.4%) original articles, 658(38.4%) reviews, and 226 (13.2%) other articles such as notes, editorials or letters. The USA took the first place with 385 appearances, followed by Ireland (n = 161), China (n = 155), and Canada (n = 144).The overall citation h-index was 106, and the countries with the highest h-index values were the USA (69), Ireland (58), and Canada (43). The cluster analysis demonstrated that the dominant fields of the MGBA include four clusters with four research directions: "modeling MGBA in animal systems", "interplay between the gut microbiota and the immune system", "irritable bowel syndrome related to gut microbiota", and "neurodegenerative diseases related to gut microbiota".
    CONCLUSIONS: This study demonstrates that the research on the MGBA has been becoming progressively more extensive at global level over the past 10 years. Overall, our study found that a large amount of work on MGBA focused on immunomodulation, irritable bowel syndrome, and neurodevelopmental disorders. Despite considerable progress illustrating the communication between the gut microbiome and the brain over the past 10 years, many issues remain about their relevance for therapeutic intervention of many diseases.
    Keywords:  Bibliometric; Gut microbiome-brain axis; Gut microbiota; Microbiome; Scopus
  6. SAGE Open Med. 2019 ;7 2050312119871062
    Wang J, Coles-Black J, Radojcic M, Chuen J, Smart P.
      Objectives: High-quality research is fundamental to the advancement of surgical practice. Currently, there is no quantitative assessment of the research output of vascular surgeons in Australia and New Zealand. By conducting this bibliometric analysis, we aim to provide an objective representation of the trends in vascular surgery and guide future research.Methods: A list of all current vascular surgeons in Australia and New Zealand was compiled from the Royal Australasian College of Surgeons 'Find a Surgeon' website tool and correlated with the Australia and New Zealand Society for Vascular Surgery database. A Scopus search of each surgeon's author profile over the last 20 years was conducted.
    Results: In total, 2120 articles were published by 208 Australasian vascular surgeons between 1998 and July 2018, with an overall increase in publications over time. Audits or case series were the most published type of study and only 8% of the publications were of high-level evidence. The most popular topics were thoracoabdominal aortic pathologies (24%), followed by peripheral arterial disease (15%). Chronological analysis illustrates an increasing volume of peripheral arterial disease research over time and there is a clear trend towards more endovascular and hybrid surgery publications. The top 10 (5%) highest publishing authors by h-index account for 41% of all publications and 49% of all citations and are also responsible for producing significantly more high-level evidence research.
    Conclusion: Australasian vascular surgeons have made a significant contribution to medical research. However, the majority of these articles are of low-level evidence. In this time, there has been an increasing number of publications on endovascular and hybrid surgery in keeping with the trend in clinical practice. These areas, as well as research regarding peripheral arterial disease, show potential for high-evidence research in the future.
    Keywords:  Vascular surgical procedures; bibliometrics; endovascular procedures; research; vascular diseases
  7. Ir J Med Sci. 2019 Aug 28.
    Abdelaal Ahmed Mahmoud A, Younis MI, Holmes C, Sallam A, Kamel MG, Dempsey E, Mulhern O.
      BACKGROUND: This study provides an accurate awareness of the present situation of health research in Irish hospitals both public and private. We aimed to analyze factors that may influence it and provide recommendations for active steps to improve the current situation of Irish health research based on our findings.METHODS: We performed a bibliometric analysis to assess qualitatively and quantitatively the publications from Ireland over a period between 2007 and 2018. We also investigated the associated variables with the quality of research. Furthermore, we conducted a Joinpoint analysis to see the trends in Irish research over these years.
    RESULTS: From 12,828 included peer-reviewed articles, the average citation count per article was 19.98. Furthermore, we showed that a higher impact factor (IF) and institutions number, present per article, were significantly associated with more citations. Also, the publication count and the mean IF showed an increase over the years according to the Joinpoint analysis. Moreover, the oncology research had the highest output, followed by pediatrics, then neurology while the specialties with least publications were ear, nose, and throat (ENT), urology, plastic surgery, and dentistry. Additionally, cardiovascular, obstetrics and gynecology, oncology, pediatrics, pulmonology, dermatology, ophthalmology, dentistry, and radiology research showed an increased publication count trend in recent years. While anesthesiology, ENT, general surgery, gastroenterology and hepatology, infection and tropical medicine, nephrology, neurology, orthopedics, plastic surgery, and urology showed a decrease in the publications trend.
    CONCLUSIONS: Our findings may serve as a useful approach to benchmark scientific output from hospitals and guide the future allocation of research spending.
    Keywords:  Bibliometric; Irish; Publications; Republic of Ireland; Research
  8. J Neurosurg. 2019 Aug 30. pii: 2019.1.JNS181531. [Epub ahead of print] 1-10
    Jahangiri A, Flanigan PM, Arnush M, Chandra A, Rick JW, Choi S, Chou A, Berger MS, Aghi MK.
      OBJECTIVE: Neurosurgeons play an important role in advancing medicine through research, the funding of which is historically linked to the National Institutes of Health (NIH). The authors defined variables associated with neurosurgical NIH funding, prevalence of funded topics by neurosurgical subspecialty, and temporal trends in NIH neurosurgical funding.METHODS: The authors conducted a retrospective review of NIH-funded American Association of Neurological Surgeons members using NIH RePORTER ( for the years 1991-2015.
    RESULTS: The authors followed 6515 neurosurgeons from 1991 to 2015, including 6107 (94%) non-MD-PhD physicians and 408 (6%) MD-PhDs. NIH grants were awarded to 393 (6%) neurosurgeons, with 23.2% of all first-time grants awarded to the top 5 funded institutions. The average total funded grant-years per funded neurosurgeon was 12.5 (range 1-85 grant-years). A higher percentage of MD-PhDs were NIH funded than MDs (22% [n = 91] vs 5% [n = 297], p < 0.0001). The most common grants awarded were R01 (128, 33%), K08 (69, 18%), F32 (60, 15%), M01 (50, 13%), and R21 (39, 10%). F32 and K08 recipients were 9-fold (18% vs 2%, p < 0.001) and 19-fold (38% vs 2%, p < 0.001) more likely to procure an R01 and procured R01 funding earlier in their careers (F32: 7 vs 12 years after residency, p = 0.03; K08: 9 vs 12 years, p = 0.01). Each year, the number of neurosurgeons with active grants linearly increased by 2.2 (R2 = 0.81, p < 0.001), whereas the number of total active grants run by neurosurgeons increased at nearly twice the rate (4.0 grants/year) (R2 = 0.91, p < 0.001). Of NIH-funded neurosurgical grants, 33 (9%) transitioned to funded clinical trial(s). Funded neurosurgical subspecialties included neuro-oncology (33%), functional/epilepsy (32%), cerebrovascular (17%), trauma (10%), and spine (6%). Finally, the authors modeled trends in the number of active training grants and found a linear increase in active R01s (R2 = 0.95, p < 0.001); however, both F32 (R2 = 0.36, p = 0.01) and K08 (R2 = 0.67, p < 0.001) funding had a significant parabolic rise and fall centered around 2003.
    CONCLUSIONS: The authors observed an upward trend in R01s awarded to neurosurgeons during the last quarter century. However, their findings of decreased K08 and F32 training grant funding to neurosurgeons and the impact of these training grants on the ultimate success and time to success for neurosurgeons seeking R01 funding suggests that this upward trend in R01 funding for neurosurgeons will be difficult to maintain. The authors' work underscores the importance of continued selection and mentorship of neurosurgeons capable of impacting patient care through research, including the MD-PhDs, who are noted to be more represented among NIH-funded neurosurgeons.
    Keywords:  AANS = American Association of Neurological Surgeons; MGH = Massachusetts General Hospital; NIH; NIH = National Institutes of Health; PI = principal investigator; SPORE = Specialized Programs of Research Excellence; UCLA = University of California, Los Angeles; UCSF = University of California, San Francisco; funding; grant; neurosurgeon-scientist; neurosurgery; physician-scientist
  9. J Ethnobiol Ethnomed. 2019 Aug 28. 15(1): 44
    da Silva TC, de Medeiros PM, Hanazaki N, da Fonseca-Kruel VS, Hora JSL, de Medeiros SG.
      BACKGROUND: The article aims to analyze the representativeness of women in ethnobiological publications within the Brazilian context, as well as to relate the difficulties faced by women in their scientific careers in terms of gender bias. Biases found in publications are relevant themes to different areas of knowledge, considering the historical persistence of male privilege in these activities. We analyzed the role of women in ethnobiological scientific publications and sought to reflect on gender issues in academic practices and fieldwork.METHODS: We conducted a 28-year survey of academic publications in Brazil, through the Scopus and Web of Science databases, in order to infer the female representation in ethnobiological literature. We also sent 77 questionnaires to ethnobiologists associated with the Brazilian society of ethnobiology and ethnoecology or indicted by associates through snowball sampling.
    RESULTS: We observed that there are more articles where the senior author is male (p < 0.05). However, there are no differences in the number of publications led by men and women (p > 0.05), which shows a positive trend in terms of representation. Within subareas, ethnozoology had more male authors than other subareas of ethnobiology. Articles whose senior authors are men tend to be published in journals with a higher impact (p < 0.05). The interviews with Brazilian ethnobiologists showed that 53.2% of the interviewees reported feeling discriminated against in the academic environment because they were women. Moreover, 61.0% said they had disadvantages in collecting data because they were women. Additionally, most of the researchers reported having witnessed cases of sexism in the studied communities.
    CONCLUSION: In the current scenarios of female participation, it is possible to reflect and identify advances and challenges associated with gender bias in ethnobiological studies conducted by Brazilian, both in the emic and etic spheres of research and in our scientific practice. As researchers in the area, we deal directly with social problems in the studied communities, such as violence against women, sexism, and prejudice, as well as the many problems faced in the academic universe itself.
    Keywords:  Ethnobiology; Gender bias; Sexism; Social influences; Women in science
  10. Insights Imaging. 2019 Aug 28. 10(1): 79
    Valderrama-Zurián JC, Castelló-Cogollos L, Aleixandre-Benavent R.
      OBJECTIVES: To analyse the coverage and main bibliometric indicators of Insights into Imaging in Scopus and the Emerging Sources Citation Index (ESCI) from the Web of Science Core Collection database.METHODS: The evolution of journal production in the Scopus database was analysed according to document types, collaboration indexes between authors and institutions, and citation indicators (number of citations, SCImago Journal Rank, quartile, h-index, and most cited works). Networks of collaboration among authors, institutions, and countries were also analysed, as well as those of co-word networks. As a complementary source of information, the Emerging Source Citation Index from the Web of Science database was also considered.
    RESULTS: Four hundred seventy-four papers were included in Scopus and 292 in ESCI. The index of collaboration was 5.18 for authors and 2.74 for institutions. International collaboration occurred in 24.7% of the papers. The number of citations received in Scopus (4295) exceeds the number of citations received in ESCI (1177). The average number of citations per paper was 9.06 in Scopus versus 4.03 in ESCI. The h-index was 29 in Scopus and 16 in ESCI. Several collaborative groups were identified at the national and international level.
    CONCLUSIONS: There is a progression of Insights into Imaging in the ranking of journals in the area that, if maintained, will allow it to remain in the first quartile in the Scopus database. The main topics of interest were technologies such as 'Magnetic resonance imaging', 'Computed tomography', 'Radiology', and 'Ultrasonography' and diseases such as 'Breast cancer' and those related to 'Paediatrics'.
    Keywords:  Bibliographic; Bibliometrics; Databases; Diagnostic imaging; Journal impact factor; Publications
  11. Medicine (Baltimore). 2019 Aug;98(35): e16817
    Zou Y, Luo Y, Zhang J, Xia N, Tan G, Huang C.
      BACKGROUND: Accumulating evidence in the last decade has pointed to the effectiveness of oncolytic virus in the treatment of a variety of cancer types in preclinical or clinical studies, showing high potency and low toxicity compared to conventional treatments. To track this research trend and highlight future directions, we conducted a bibliometric analysis of oncolytic virus research to date.METHODS: Relevant studies were obtained from the Web of Science Core Collection between January 2000 and December 2018. Data were collected in terms of the number of publications, country, journal of publication, journal scope, author, and keywords or topics. Analysis and visual representation of the data were performed with CiteSpace V.
    RESULTS: The trend in publications related to oncolytic virus showed a dramatic increase, from 10 publications in 2000 to 199 publications in 2018. The United States clearly dominates this field (981 publications, 52.770%), followed by Canada (244, 13.125%) and China (205, 11.027%). The top 15 academic journals account for over one third of the total publications on oncolytic virus research (724, 38.95%). Most of the related papers were published in journals with a focus on biology, medicine, immunology, medicine, molecular biology, and clinical perspectives, as represented by the dual-map overlay. The most highly cited papers were published in journals in the fields of nursing, molecular biology, general biology, genetics, health, and medicine. Over 1300 institutions have focused their attention on oncolytic virus research to date, and cooperation among mainstream institutions is common.
    CONCLUSION: The global field of oncolytic virus research has expanded at a rapid pace from 2000 to 2018. There is no doubt that North America currently has the most powerful impact on the field with respect to both productivity and contribution. However, European and some East Asian institutions are also prominent in this field. Overall, this bibliometric study identifies the top 4 hotspots in oncolytic virus research: T-cells, vaccinia virus, dendritic cells, and apoptosis. Thus, further research focuses on these topics may be more helpful to promote the clinical translation of this treatment strategy to bring a benefit to cancer patients in the near future.
  12. Int Endod J. 2019 Aug 27.
    Ordinola-Zapata R, Peters O, Nagendrababu V, Azevedo B, Dummer P, Neelakantan P.
      AIM: To report the most common terminology used in titles of scientific papers published in the International Endodontic Journal (IEJ) and Journal of Endodontics (JOE) between 1980-2019 and to identify the most cited papers in these journals.METHODOLOGY: The Web of Science database was searched to retrieve all the manuscripts published in the IEJ and JOE between 1980 and 2019. The articles were analyzed using the VOS viewer software and the terms within the titles extracted. The top-10 terms were categorized according to the number of occurrences and the decade of publication. Maps were created using the text data for each decade of publication. Classic papers were identified when the number of citations was >400. During the same period of time, highly cited studies were identified including the authors, institutions and countries associated with these papers.
    RESULTS: Terms such as canal, molar and periapical lesion were the most commonly used in titles between 1980 and 1999. The terms instruments, expression, case report and cell were the most often terms used between 2000 and 2019. During the last 10 years an increase in the number of reviews and papers on Cone Beam Computed Tomography occurred. The organizations with the largest number of citations in each decade were University of São Paulo, University College London, Loma Linda University and United States Army. The country with the largest number of citations and greatest number of top 10 and top 100 manuscripts was the USA. A paper had to be associated with more than 167 citations to be included in the top-100 most cited list; at least 14 papers met the criteria to be categorized as a citation classic (>400 citations).
    CONCLUSION: While many diverse areas of Endodontics have been explored in the last 40 years only a relatively few topics are highly-cited and can be considered as classics. This article is protected by copyright. All rights reserved.
    Keywords:  Endodontology; citations; impact factor; review
  13. Int J Impot Res. 2019 Aug 31.
    Hui J, He S, Liu R, Zeng Q, Zhang H, Wei A.
      An amendment to this paper has been published and can be accessed via a link at the top of the paper.
  14. Front Hum Neurosci. 2019 ;13 259
    Dong R, Wang H, Ye J, Wang M, Bi Y.
      Background: Alzheimer's disease, the most common form of dementia, has tremendous social and economic impact worldwide. This study aimed to analyze global trends in Alzheimer's disease research and to investigate China's contribution to this research. Methods: The quantity and influence of publications related to Alzheimer's disease in China and elsewhere were compared. The Web of Science (WOS) and PubMed databases were searched from 1988 to 2017 using the terms "Alzheimer's disease" or "Alzheimers disease." Global Alzheimer's disease publications were classified and analyzed. Keywords, countries, and institutions publishing articles on Alzheimer's disease were analyzed, and citations of these articles were examined. Results: A total of 181,116 articles regarding Alzheimer's disease research were identified and analyzed. Neuroscience and neurology were the main research categories both globally and in China. Basic research dominated Alzheimer's publications, accounting for 30.93% of global publications and 95.31% of publications in China. A total of 8,935 journals published articles related to Alzheimer's disease. The journal Neurobiology of Aging published the most Alzheimer's disease-related articles, numbering 5,206 over the time period examined. The National Institutes of Health, the National Institute on Aging, and the Department of Health and Human Services jointly sponsored 11,809 articles, ranking first in the world. The National Natural Science Foundation of China funded the largest number of studies on Alzheimer's disease in China and recognized the importance of traditional Chinese medicine in Alzheimer's disease research. Conclusions: The present study provides data for global researchers to understand research perspectives and develop future research directions. In recent years, Chinese researchers have contributed significantly to global Alzheimer's research. Still, strengthening international cooperation could improve the quality and number of publications regarding Alzheimer's disease.
    Keywords:  Alzheimer's disease; China; PubMed; bibliometric analysis; traditional Chinese medicine; web of science
  15. Anaesthesia. 2019 Aug 31.
    Charlesworth M, Klein AA, White SM.
      Pilot and feasibility studies are preliminary investigations undertaken before a larger study. We hypothesised that only a small proportion of pilot or feasibility studies published in anaesthesia journals were correctly labelled as such. We searched for papers published between 2007 and 2017 in six anaesthesia journals using the text words 'pilot' OR 'feasibility' and included 266 original articles with 26,682 human participants. Only 34 (12.8%) were correctly labelled as a pilot or feasibility study. They were more likely to: have more median (IQR [range]) participants, 73 (40-130 [4-2716]) vs. 27 (15-60 [2-3305], p < 0.001; report feasibility outcomes, 82.4% vs. 4.3%, p < 0.001; and report an intention to convert, 100% vs. 39.7%, p < 0.001. They were less likely to test the efficacy of the primary outcome, 50% vs. 72.8%, p = 0.009; and report firm clinical conclusions 41.2% vs. 67.7%, p = 0.004. Of the studies published more than 5 years ago, correctly labelled pilot or feasibility studies were more likely to precede a published conversion study, 53.8% vs. 16%, p = 0.004. There was no difference between the number of citations 18 (9-44 [2-216]) vs. 20 (7-47 [0-251]), p = 0.865. These results have important consequences for patients, trialists, researchers and funders. We argue that correctly labelled pilot studies enhance the quality of scientific research by encouraging methodological rigour, ensuring scientific validity and reducing research waste. Authors, reviewers, editors and publishers should ensure they adhere to the contents of the 2016 CONSORT extension for pilot and feasibility studies.
    Keywords:  feasibility; peri-operative; pilot; trial
  16. Int J Cancer. 2019 Aug 31.
    Dijksterhuis WPM, Stroes CI, Tan WL, Ithimakin S, Calles A, van Oijen MGH, Verhoeven RHA, Barriuso J, Oosting SF, Kolarevic Ivankovic D, Furness AJS, Bozovic-Spasojevic I, Gomez-Roca C, van Laarhoven HWM.
      Gender disparities in scientific publications have been identified in oncological research. Oral research presentations at major conferences enhance visibility of presenters. The share of women presenting at such podia is unknown. We aim to identify gender-based differences in contributions to presentations at two major oncological conferences. Abstracts presented at plenary sessions of the American Society of Clinical Oncology (ASCO) Annual Meetings and European Society for Medical Oncology (ESMO) Congresses were collected. Trend analyses were used to analyze female contribution over time. The association between presenter's sex, study outcome (positive/negative) and journals' impact factors of subsequently published papers was assessed using Chi-square and Mann-Whitney U tests. Of 166 consecutive abstracts presented at ASCO in 2011-2018 (n = 34), and ESMO in 2008-2018 (n = 132), 21% had female presenters, all originating from Northern America (n = 17) or Europe (n = 18). The distribution of presenter's sex was similar over time (P = 0.70). Of 2,425 contributing authors to these presented abstracts, 28% were women. The proportion of female abstract authors increased over time (P < 0.05), and was higher in abstracts with female (34%) compared to male presenters (26%; P < 0.01). Presenter's sex was not associated with study outcome (P = 0.82). Median journals' impact factors were lower in papers with a female first author (P < 0.05). In conclusion, there is a clear gender disparity in research presentations at two major oncological conferences, with 28% of authors and 21% of presenters of these studies being female. Lack of visibility of female presenters could impair acknowledgement for their research, opportunities in their academic career, and even hamper heterogeneity in research. This article is protected by copyright. All rights reserved.
    Keywords:  Congresses as Topic; Medical Oncology; Research; Sex
  17. Evid Based Complement Alternat Med. 2019 ;2019 1704816
    Lu C, Bing Z, Bi Z, Liu M, Lu T, Xun Y, Wei Z, Yang K.
      Background: Network pharmacology (NP) has become an increasingly important focus in the drug research field over the past decade. However, no study to date has mapped the current status of NP. Therefore, we performed a bibliometric study to evaluate the top 100 cited papers on NP.Methods: We searched the Web of Science Core Collection from its inception to February 25, 2019, using the terms "network pharmacology" and "systems pharmacology." Key data, including title, publication year, number of citations, authors, countries/regions, organizations, and journals, were retrieved and analyzed using Excel 2016 and VOSviewer 1.6.10.
    Results: The total number of citations for the 100 cited papers ranged from 21 to 1,238, published in 53 journals, from 2005 to 2017. The top three journals with the most publications on NP were Clinical Pharmacology & Therapeutics (n = 8, IF2017 = 6.544), Journal of Ethnopharmacology (n = 8, IF2017 = 3.115), and PLoS One (n = 7, IF2017 = 2.766). Most published articles were from the USA (n = 41) and China (n = 35). The most active author was Wang Yonghua from the Northwest A&F University, and of the 100 publications, 14 listing his name. The most frequently used substantive terms included "drug discovery," "traditional Chinese medicine (TCM)," "in-vitro," "cancer," and "cardiovascular disease." Conclusions. The USA and China made the greatest contribution to NP research. The current NP research mainly focused on NP methods (including experimental validation) and using them to explore the molecular mechanisms of TCM for some critical diseases such as cardiovascular diseases and cancers. Furthermore, we believe some guidelines should be developed to regulate NP studies.