bims-climfi Biomed News
on Cerebellar cortical circuitry
Issue of 2021‒01‒03
one paper selected by
Jun Maruta
Mount Sinai Health System

  1. Cell Rep. 2020 Dec 22. pii: S2211-1247(20)31526-6. [Epub ahead of print]33(12): 108537
    Tsutsumi S, Chadney O, Yiu TL, Bäumler E, Faraggiana L, Beau M, Häusser M.
      Cerebellar neurons can signal sensory and motor events, but their role in active sensorimotor processing remains unclear. We record and manipulate Purkinje cell activity during a task that requires mice to rapidly discriminate between multisensory and unisensory stimuli before motor initiation. Neuropixels recordings show that both sensory stimuli and motor initiation are represented by short-latency simple spikes. Optogenetic manipulation of short-latency simple spikes abolishes or delays motor initiation in a rate-dependent manner, indicating a role in motor initiation and its timing. Two-photon calcium imaging reveals task-related coherence of complex spikes organized into conserved alternating parasagittal stripes. The coherence of sensory-evoked complex spikes increases with learning and correlates with enhanced temporal precision of motor initiation. These results suggest that both simple spikes and complex spikes govern sensory-driven motor initiation: simple spikes modulate its latency, and complex spikes refine its temporal precision, providing specific cellular substrates for cerebellar sensorimotor control.
    Keywords:  purkinje cells, simple spikes, complex spikestwo-photon imaging, optogenetics, neuropixels, cerebellum, multisensory, timing, motor initiation