bims-climfi Biomed News
on Cerebellar cortical circuitry
Issue of 2020‒10‒25
one paper selected by
Jun Maruta
Mount Sinai Health System


  1. Neuroscience. 2020 Oct 16. pii: S0306-4522(20)30661-8. [Epub ahead of print]
    Kim J, Augustine GJ.
      Molecular layer interneurons (MLIs) play an important role in cerebellar information processing by controlling Purkinje cell (PC) activity via inhibitory synaptic transmission. A local MLI network, constructed from both chemical and electrical synapses, is organized into spatially structured clusters that amplify feedforward and lateral inhibition to shape the temporal and spatial patterns of PC activity. Several recent in vivo studies indicate that such MLI circuits contribute not only to sensorimotor information processing, but also contribute to precise motor coordination and cognitive processes. Here, we review current understanding of the organization of MLI circuits and their roles in the function of the mammalian cerebellum.
    Keywords:  cognitive outcomes; convergence; electrical synapses; molecular layer interneurons; network organization
    DOI:  https://doi.org/10.1016/j.neuroscience.2020.10.008