bims-climfi Biomed News
on Cerebellar cortical circuitry
Issue of 2020‒08‒16
one paper selected by
Jun Maruta
Mount Sinai Health System


  1. Neuroscience. 2020 Aug 06. pii: S0306-4522(20)30502-9. [Epub ahead of print]
    Takahashi M, Shinoda Y.
      This article is dedicated to the memory of Masao Ito. Masao Ito made numerous important contributions revealing the function of the cerebellum in motor control. His pioneering contributions to cerebellar physiology began with his discovery of inhibition and disinhibition of target neurons by cerebellar Purkinje cells, and his discovery of the presence of long-term depression in parallel fiber-Purkinje cell synapses. Purkinje cells formed the nodal point of Masao Ito's landmark model of motor control by the cerebellum. These discoveries became the basis for his ideas regarding the flocculus hypothesis, the adaptive motor control system, and motor learning by the cerebellum, inspiring many new experiments to test his hypotheses. This article will trace the achievements of Ito and colleagues in analyzing the neural circuits of the input-output organization of the cerebellar cortex and nuclei, particularly with respect to motor control. The article will discuss some of the important issues that have been solved and also those that remain to be solved for our understanding of motor control by the cerebellum.
    Keywords:  Purkinje cell; cerebello-cerebral loop; climbing fiber; flocculus; mossy fiber; vestibular nucleus
    DOI:  https://doi.org/10.1016/j.neuroscience.2020.07.051