bims-ciryme Biomed News
on Circadian rhythms and metabolism
Issue of 2021‒04‒18
three papers selected by
Gabriela Da Silva Xavier
University of Birmingham
  1. Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
  2. Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
  3. Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
  1. Science. 2021 Apr 16. pii: eabf1930. [Epub ahead of print]372(6539):
    Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
    Sandipan Ray, Utham K Valekunja, Alessandra Stangherlin, Steven A Howell, Ambrosius P Snijders, Gopinath Damodaran, Akhilesh B Reddy.
      Ness-Cohn et al claim that our observations of transcriptional circadian rhythms in the absence of the core clock gene Bmal1 in mouse skin fibroblast cells are supported by inadequate evidence. They claim that they were unable to reproduce some of the original findings with their reanalysis. We disagree with their analyses and outlook.
    DOI:  https://doi.org/10.1126/science.abf1930
  2. Science. 2021 Apr 16. pii: eabf1941. [Epub ahead of print]372(6539):
    Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
    Sandipan Ray, Utham K Valekunja, Alessandra Stangherlin, Steven A Howell, Ambrosius P Snijders, Gopinath Damodaran, Akhilesh B Reddy.
      Abruzzi et al argue that transcriptome oscillations found in our study in the absence of Bmal1 are of low amplitude, statistical significance, and consistency. However, their conclusions rely solely on a different statistical algorithm than we used. We provide statistical measures and additional analyses showing that our original analyses and observations are accurate. Further, we highlight independent lines of evidence indicating Bmal1-independent 24-hour molecular oscillations.
    DOI:  https://doi.org/10.1126/science.abf1941
  3. Science. 2021 Apr 16. pii: eabe9230. [Epub ahead of print]372(6539):
    Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
    Elan Ness-Cohn, Ravi Allada, Rosemary Braun.
      Ray et al (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of Bmal1.
    DOI:  https://doi.org/10.1126/science.abe9230
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