bims-ciryme Biomed news
on Circadian rhythms and metabolism
Issue of 2019‒02‒17
one paper selected by
Gabriela Da Silva Xavier
University of Birmingham


  1. Curr Biol. 2019 Jan 29. pii: S0960-9822(19)30024-7. [Epub ahead of print]
    Padilla SL, Perez JG, Ben-Hamo M, Johnson CW, Sanchez REA, Bussi IL, Palmiter RD, de la Iglesia HO.
      Successful reproduction in female mammals is precisely timed and must be able to withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin-expressing neurons in the arcuate hypothalamus (Kiss1ARH) of female mice control the daily timing of food intake, along with the circadian regulation of locomotor activity, sleep, and core body temperature. Toxin-induced silencing of Kiss1ARH neurons shifts wakefulness and food consumption to the light phase and induces weight gain. Toxin-silenced mice are less physically active and have attenuated temperature rhythms. Because the rhythm of the master clock in the suprachiasmatic nucleus (SCN) appears to be intact, we hypothesize that Kiss1ARH neurons signal to neurons downstream of the master clock to modulate the output of the SCN. We conclude that, in addition to their well-established role in regulating fertility, Kiss1ARH neurons are a critical component of the hypothalamic circadian oscillator network that times overt rhythms of physiology and behavior.
    Keywords:  body temperature; body weight; circadian rhythm; estrogen; kisspeptin; menopause; neural circuits; neurophysiology; shift work; sleep
    DOI:  https://doi.org/10.1016/j.cub.2019.01.022